Overlap of Neuroanatomical Involvement in Frontotemporal Dementia and Primary Psychiatric Disorders : A Meta-analysis
(2023) In Biological Psychiatry 93(9). p.820-828- Abstract
Background: Despite significant symptomatic overlap between behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPDs), a potential overlap in their structural anatomical changes has not been studied systematically. Methods: In this magnetic resonance imaging-based meta-analysis, we included studies on bvFTD, schizophrenia, bipolar disorder, and autism spectrum disorder that 1) used voxel-based morphometry analysis to assess regional gray matter volumes (GMVs) and 2) reported the coordinates of the regional GMV. Separate analyses were performed comparing clusters of coordinate-based changes in the GMVs (n = 24,183) between patients and control subjects, and overlapping brain regions between bvFTD and... (More)
Background: Despite significant symptomatic overlap between behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPDs), a potential overlap in their structural anatomical changes has not been studied systematically. Methods: In this magnetic resonance imaging-based meta-analysis, we included studies on bvFTD, schizophrenia, bipolar disorder, and autism spectrum disorder that 1) used voxel-based morphometry analysis to assess regional gray matter volumes (GMVs) and 2) reported the coordinates of the regional GMV. Separate analyses were performed comparing clusters of coordinate-based changes in the GMVs (n = 24,183) between patients and control subjects, and overlapping brain regions between bvFTD and each PPD were examined. Results: We found that GMV alterations in the prefrontal and anterior cingulate cortices, temporal lobe, amygdala, and insula comprise the transdiagnostic brain alterations in bvFTD and PPD. Conclusions: Our meta-analysis revealed significant anatomical overlap that paves the way for future investigations of shared pathophysiological pathways, and our cross-disorder approach would provide new insights to better understand the relationship between bvFTD and PPD.
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- author
- Ulugut, Hulya ; Trieu, Calvin ; Groot, Colin ; van ’t Hooft, Jochum J. ; Tijms, Betty M. ; Scheltens, Philip ; Ossenkoppele, Rik LU ; Barkhof, Frederik ; van den Heuvel, Odile A. and Pijnenburg, Yolande A.L.
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Autism spectrum disorder, Behavior, Bipolar disorder, Dementia, Frontotemporal dementia, Schizophrenia
- in
- Biological Psychiatry
- volume
- 93
- issue
- 9
- pages
- 820 - 828
- publisher
- Elsevier
- external identifiers
-
- pmid:35965106
- scopus:85136749563
- ISSN
- 0006-3223
- DOI
- 10.1016/j.biopsych.2022.05.028
- language
- English
- LU publication?
- yes
- id
- f5fee8ec-f5bd-44c2-8b73-77c080b34d15
- date added to LUP
- 2022-10-24 13:48:22
- date last changed
- 2024-09-05 16:13:53
@article{f5fee8ec-f5bd-44c2-8b73-77c080b34d15, abstract = {{<p>Background: Despite significant symptomatic overlap between behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPDs), a potential overlap in their structural anatomical changes has not been studied systematically. Methods: In this magnetic resonance imaging-based meta-analysis, we included studies on bvFTD, schizophrenia, bipolar disorder, and autism spectrum disorder that 1) used voxel-based morphometry analysis to assess regional gray matter volumes (GMVs) and 2) reported the coordinates of the regional GMV. Separate analyses were performed comparing clusters of coordinate-based changes in the GMVs (n = 24,183) between patients and control subjects, and overlapping brain regions between bvFTD and each PPD were examined. Results: We found that GMV alterations in the prefrontal and anterior cingulate cortices, temporal lobe, amygdala, and insula comprise the transdiagnostic brain alterations in bvFTD and PPD. Conclusions: Our meta-analysis revealed significant anatomical overlap that paves the way for future investigations of shared pathophysiological pathways, and our cross-disorder approach would provide new insights to better understand the relationship between bvFTD and PPD.</p>}}, author = {{Ulugut, Hulya and Trieu, Calvin and Groot, Colin and van ’t Hooft, Jochum J. and Tijms, Betty M. and Scheltens, Philip and Ossenkoppele, Rik and Barkhof, Frederik and van den Heuvel, Odile A. and Pijnenburg, Yolande A.L.}}, issn = {{0006-3223}}, keywords = {{Autism spectrum disorder; Behavior; Bipolar disorder; Dementia; Frontotemporal dementia; Schizophrenia}}, language = {{eng}}, number = {{9}}, pages = {{820--828}}, publisher = {{Elsevier}}, series = {{Biological Psychiatry}}, title = {{Overlap of Neuroanatomical Involvement in Frontotemporal Dementia and Primary Psychiatric Disorders : A Meta-analysis}}, url = {{http://dx.doi.org/10.1016/j.biopsych.2022.05.028}}, doi = {{10.1016/j.biopsych.2022.05.028}}, volume = {{93}}, year = {{2023}}, }