Chronic inflammation in the etiology of disease across the life span
(2019) In Nature Medicine 25(12). p.1822-1832- Abstract
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet,... (More)
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
(Less)
- author
- organization
- publishing date
- 2019-12-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Medicine
- volume
- 25
- issue
- 12
- pages
- 1822 - 1832
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:31806905
- scopus:85076175435
- ISSN
- 1078-8956
- DOI
- 10.1038/s41591-019-0675-0
- language
- English
- LU publication?
- yes
- id
- f6280925-1770-4625-b4e3-86bb13ee24fc
- date added to LUP
- 2020-11-03 16:52:34
- date last changed
- 2024-09-19 08:02:12
@article{f6280925-1770-4625-b4e3-86bb13ee24fc, abstract = {{<p>Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.</p>}}, author = {{Furman, David and Campisi, Judith and Verdin, Eric and Carrera-Bastos, Pedro and Targ, Sasha and Franceschi, Claudio and Ferrucci, Luigi and Gilroy, Derek W. and Fasano, Alessio and Miller, Gary W. and Miller, Andrew H. and Mantovani, Alberto and Weyand, Cornelia M. and Barzilai, Nir and Goronzy, Jorg J. and Rando, Thomas A. and Effros, Rita B. and Lucia, Alejandro and Kleinstreuer, Nicole and Slavich, George M.}}, issn = {{1078-8956}}, language = {{eng}}, month = {{12}}, number = {{12}}, pages = {{1822--1832}}, publisher = {{Nature Publishing Group}}, series = {{Nature Medicine}}, title = {{Chronic inflammation in the etiology of disease across the life span}}, url = {{http://dx.doi.org/10.1038/s41591-019-0675-0}}, doi = {{10.1038/s41591-019-0675-0}}, volume = {{25}}, year = {{2019}}, }