Patch Testing With Formaldehyde 2.0% (0.60 mg/cm2) Detects More Contact Allergy to Formaldehyde Than 1.0
(2019) In Dermatitis : contact, atopic, occupational, drug 30(6). p.342-346- Abstract
BACKGROUND: The International Contact Dermatitis Research Group increased the patch test concentration of formaldehyde from 1.0% aqueous (aq) to 2.0% aq (in 2011). OBJECTIVE: This study was designed to investigate the outcome of the decision. METHODS: Consecutive dermatitis patients in 8 different clinics were patch tested with formaldehyde 1.0% aq and 2.0% aq. The test solutions were applied with a micropipette to the filter paper discs in the respective chamber. RESULTS: A total of 2778 patients were tested with 1.0% aq and 2766 to 2.0% aq. Sixty-five patients (2.3%, calculated from 2766 tested, to 2.0% aq) had positive patch test reactions interpreted as contact allergy to formaldehyde. This is a rather low frequency. Of these 65, 46... (More)
BACKGROUND: The International Contact Dermatitis Research Group increased the patch test concentration of formaldehyde from 1.0% aqueous (aq) to 2.0% aq (in 2011). OBJECTIVE: This study was designed to investigate the outcome of the decision. METHODS: Consecutive dermatitis patients in 8 different clinics were patch tested with formaldehyde 1.0% aq and 2.0% aq. The test solutions were applied with a micropipette to the filter paper discs in the respective chamber. RESULTS: A total of 2778 patients were tested with 1.0% aq and 2766 to 2.0% aq. Sixty-five patients (2.3%, calculated from 2766 tested, to 2.0% aq) had positive patch test reactions interpreted as contact allergy to formaldehyde. This is a rather low frequency. Of these 65, 46 were women (46/1703 [2.7%]) and 19 were men (19/1063 [1.8%]). Thirty-six reacted only to 2.0% aq, 21 patients reacted to both concentrations, and 8 patients reacted only to 1.0% aq. Significantly, more patients reacted to 2.0% aq compared with 1.0% aq (P < 0.001). There was no significant sex difference. A total of 0.8% irritant reactions were recorded to formaldehyde 2.0% aq and 0.1% to 1.0% aq. CONCLUSIONS: The increased formaldehyde patch test concentration to 2.0% aq revealed more formaldehyde contact allergy.
(Less)
- author
- Isaksson, Marléne LU ; Ale, Iris ; Andersen, Klaus E. ; Goh, Chee Leok ; Goossens, An ; Jerajani, Hemangi ; Matsunaga, Kayoko ; McFadden, John and Bruze, Magnus LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Dermatitis : contact, atopic, occupational, drug
- volume
- 30
- issue
- 6
- pages
- 5 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:31730552
- scopus:85075056791
- ISSN
- 1710-3568
- DOI
- 10.1097/DER.0000000000000510
- language
- English
- LU publication?
- yes
- id
- f7364e99-d238-4e37-ad96-5b7b4f644c93
- date added to LUP
- 2019-11-29 14:28:20
- date last changed
- 2024-08-22 11:08:11
@article{f7364e99-d238-4e37-ad96-5b7b4f644c93, abstract = {{<p>BACKGROUND: The International Contact Dermatitis Research Group increased the patch test concentration of formaldehyde from 1.0% aqueous (aq) to 2.0% aq (in 2011). OBJECTIVE: This study was designed to investigate the outcome of the decision. METHODS: Consecutive dermatitis patients in 8 different clinics were patch tested with formaldehyde 1.0% aq and 2.0% aq. The test solutions were applied with a micropipette to the filter paper discs in the respective chamber. RESULTS: A total of 2778 patients were tested with 1.0% aq and 2766 to 2.0% aq. Sixty-five patients (2.3%, calculated from 2766 tested, to 2.0% aq) had positive patch test reactions interpreted as contact allergy to formaldehyde. This is a rather low frequency. Of these 65, 46 were women (46/1703 [2.7%]) and 19 were men (19/1063 [1.8%]). Thirty-six reacted only to 2.0% aq, 21 patients reacted to both concentrations, and 8 patients reacted only to 1.0% aq. Significantly, more patients reacted to 2.0% aq compared with 1.0% aq (P < 0.001). There was no significant sex difference. A total of 0.8% irritant reactions were recorded to formaldehyde 2.0% aq and 0.1% to 1.0% aq. CONCLUSIONS: The increased formaldehyde patch test concentration to 2.0% aq revealed more formaldehyde contact allergy.</p>}}, author = {{Isaksson, Marléne and Ale, Iris and Andersen, Klaus E. and Goh, Chee Leok and Goossens, An and Jerajani, Hemangi and Matsunaga, Kayoko and McFadden, John and Bruze, Magnus}}, issn = {{1710-3568}}, language = {{eng}}, number = {{6}}, pages = {{342--346}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Dermatitis : contact, atopic, occupational, drug}}, title = {{Patch Testing With Formaldehyde 2.0% (0.60 mg/cm2) Detects More Contact Allergy to Formaldehyde Than 1.0}}, url = {{http://dx.doi.org/10.1097/DER.0000000000000510}}, doi = {{10.1097/DER.0000000000000510}}, volume = {{30}}, year = {{2019}}, }