A genetic risk score for fasting plasma glucose is independently associatedwith arterial stiffness : A Mendelian randomization study
Gottsäter, Mikael LU ; Hindy, George LU ; Orho-Melander, Marju LU ; Nilsson, Peter M. LU and Melander, Olle LU
(2018)
In Journal of Hypertension
36(4).
p.809-814
- Abstract
Background: Arterial stiffness is known to be associated with a number of clinical conditions including hypertension, diabetes and dyslipidemia, and may predict cardiovascular events and mortality. However, causal links are hard to establish. Results from genome-wide association studies have identified only a few single nucleotide polymorphisms associated with arterial stiffness, the results have been inconsistent between studies and overlap with other clinical conditions is lacking. Our aim was to investigate a potential shared set of risk single nucleotide polymorphisms between relevant cardiometabolic traits and arterial stiffness. Method: The study population consisted of 2853 individuals (mean age 72 years, 40% men) from the... (More)
Background: Arterial stiffness is known to be associated with a number of clinical conditions including hypertension, diabetes and dyslipidemia, and may predict cardiovascular events and mortality. However, causal links are hard to establish. Results from genome-wide association studies have identified only a few single nucleotide polymorphisms associated with arterial stiffness, the results have been inconsistent between studies and overlap with other clinical conditions is lacking. Our aim was to investigate a potential shared set of risk single nucleotide polymorphisms between relevant cardiometabolic traits and arterial stiffness. Method: The study population consisted of 2853 individuals (mean age 72 years, 40% men) from the population-based Malmö Diet and Cancer study, Sweden. Carotid-femoral pulse wave velocity, a marker of arterial stiffness, was measured with Sphygmocor. Mendelian randomization analyses were performed using the twostage least square regression and multivariate inversevariance weighted methods. Results: There were positive associations between arterial stiffness and genetic risk scores for type 2 diabetes (β=0.03, P=0.04) and fasting plasma glucose (β=0.03, P=0.03), but not for systolic blood pressure, body mass index, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides. Multivariate inversevariance weighted methods confirmed the significant positive association for fasting plasma glucose β coefficients (P=0.006), but not for type 2 diabetes β coefficients (P=0.88). Conclusion: Genetically elevated fasting plasma glucose, but not genetically elevated risk of type 2 diabetes, was associated with arterial stiffness suggesting a causal stiffening effect of glycemia on the arterial wall, independently of type 2 diabetes.
(Less)
- author
- Gottsäter, Mikael
LU
; Hindy, George
LU
; Orho-Melander, Marju
LU
; Nilsson, Peter M.
LU
and Melander, Olle
LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aging, Arterial stiffness, Diabetes mellitus, Epidemiology, Hyperglycemia, Mendelian randomization
- in
- Journal of Hypertension
- volume
- 36
- issue
- 4
- pages
- 6 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:29215398
- scopus:85050544074
- ISSN
- 0263-6352
- DOI
- 10.1097/HJH.0000000000001646
- language
- English
- LU publication?
- yes
- id
- f777cf21-99cd-4689-bfa3-d7ef3f9e6b1a
- date added to LUP
- 2019-10-08 10:26:40
- date last changed
- 2025-01-10 00:25:26
@article{f777cf21-99cd-4689-bfa3-d7ef3f9e6b1a,
abstract = {{<p>Background: Arterial stiffness is known to be associated with a number of clinical conditions including hypertension, diabetes and dyslipidemia, and may predict cardiovascular events and mortality. However, causal links are hard to establish. Results from genome-wide association studies have identified only a few single nucleotide polymorphisms associated with arterial stiffness, the results have been inconsistent between studies and overlap with other clinical conditions is lacking. Our aim was to investigate a potential shared set of risk single nucleotide polymorphisms between relevant cardiometabolic traits and arterial stiffness. Method: The study population consisted of 2853 individuals (mean age 72 years, 40% men) from the population-based Malmö Diet and Cancer study, Sweden. Carotid-femoral pulse wave velocity, a marker of arterial stiffness, was measured with Sphygmocor. Mendelian randomization analyses were performed using the twostage least square regression and multivariate inversevariance weighted methods. Results: There were positive associations between arterial stiffness and genetic risk scores for type 2 diabetes (β=0.03, P=0.04) and fasting plasma glucose (β=0.03, P=0.03), but not for systolic blood pressure, body mass index, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides. Multivariate inversevariance weighted methods confirmed the significant positive association for fasting plasma glucose β coefficients (P=0.006), but not for type 2 diabetes β coefficients (P=0.88). Conclusion: Genetically elevated fasting plasma glucose, but not genetically elevated risk of type 2 diabetes, was associated with arterial stiffness suggesting a causal stiffening effect of glycemia on the arterial wall, independently of type 2 diabetes.</p>}},
author = {{Gottsäter, Mikael and Hindy, George and Orho-Melander, Marju and Nilsson, Peter M. and Melander, Olle}},
issn = {{0263-6352}},
keywords = {{Aging; Arterial stiffness; Diabetes mellitus; Epidemiology; Hyperglycemia; Mendelian randomization}},
language = {{eng}},
number = {{4}},
pages = {{809--814}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{A genetic risk score for fasting plasma glucose is independently associatedwith arterial stiffness : A Mendelian randomization study}},
url = {{http://dx.doi.org/10.1097/HJH.0000000000001646}},
doi = {{10.1097/HJH.0000000000001646}},
volume = {{36}},
year = {{2018}},
}