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A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis

Leuzy, Antoine LU ; Pascoal, Tharick A. ; Strandberg, Olof LU ; Insel, Philip LU ; Smith, Ruben LU ; Mattsson-Carlgren, Niklas LU orcid ; Benedet, Andréa L. ; Cho, Hannah ; Lyoo, Chul H. and La Joie, Renaud , et al. (2021) In European Journal of Nuclear Medicine and Molecular Imaging 48(7). p.2295-2305
Abstract

Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer’s disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [18F]flortaucipir (n = 975), [18F]RO948 (n = 493), or [18F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic... (More)

Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer’s disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [18F]flortaucipir (n = 975), [18F]RO948 (n = 493), or [18F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic performance and cut-offs for ROIs were determined using receiver operating characteristic analyses and the Youden index, respectively. Results: Comparable diagnostic performance (area under the receiver operating characteristic curve [AUC]) was observed between theory- and data-driven ROIs. The theory-defined temporal meta-ROI generally performed very well for all three tracers (AUCs: 0.926–0.996). An SUVR value of approximately 1.35 was a common threshold when using this ROI. Conclusion: The temporal meta-ROI can be used for differential diagnosis of dementia patients with [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR. This ROI/SUVR cut-off can also be applied across tracers to define tau positivity.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
PET, Tau, [F]Flortaucipir, [F]MK6240, [F]RO948
in
European Journal of Nuclear Medicine and Molecular Imaging
volume
48
issue
7
pages
11 pages
publisher
Springer
external identifiers
  • scopus:85106456393
  • pmid:34041562
ISSN
1619-7070
DOI
10.1007/s00259-021-05401-4
language
English
LU publication?
yes
id
fac5e56a-9f05-4826-b035-01677632bf29
date added to LUP
2021-06-17 10:54:21
date last changed
2024-07-13 15:03:42
@article{fac5e56a-9f05-4826-b035-01677632bf29,
  abstract     = {{<p>Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [<sup>18</sup>F]flortaucipir, [<sup>18</sup>F]RO948, and [<sup>18</sup>F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer’s disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [<sup>18</sup>F]flortaucipir (n = 975), [<sup>18</sup>F]RO948 (n = 493), or [<sup>18</sup>F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic performance and cut-offs for ROIs were determined using receiver operating characteristic analyses and the Youden index, respectively. Results: Comparable diagnostic performance (area under the receiver operating characteristic curve [AUC]) was observed between theory- and data-driven ROIs. The theory-defined temporal meta-ROI generally performed very well for all three tracers (AUCs: 0.926–0.996). An SUVR value of approximately 1.35 was a common threshold when using this ROI. Conclusion: The temporal meta-ROI can be used for differential diagnosis of dementia patients with [<sup>18</sup>F]flortaucipir, [<sup>18</sup>F]RO948, and [<sup>18</sup>F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR. This ROI/SUVR cut-off can also be applied across tracers to define tau positivity.</p>}},
  author       = {{Leuzy, Antoine and Pascoal, Tharick A. and Strandberg, Olof and Insel, Philip and Smith, Ruben and Mattsson-Carlgren, Niklas and Benedet, Andréa L. and Cho, Hannah and Lyoo, Chul H. and La Joie, Renaud and Rabinovici, Gil D. and Ossenkoppele, Rik and Rosa-Neto, Pedro and Hansson, Oskar}},
  issn         = {{1619-7070}},
  keywords     = {{PET; Tau; [F]Flortaucipir; [F]MK6240; [F]RO948}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{2295--2305}},
  publisher    = {{Springer}},
  series       = {{European Journal of Nuclear Medicine and Molecular Imaging}},
  title        = {{A multicenter comparison of [<sup>18</sup>F]flortaucipir, [<sup>18</sup>F]RO948, and [<sup>18</sup>F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis}},
  url          = {{http://dx.doi.org/10.1007/s00259-021-05401-4}},
  doi          = {{10.1007/s00259-021-05401-4}},
  volume       = {{48}},
  year         = {{2021}},
}