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Assessment of precision and accuracy of brain white matter microstructure using combined diffusion MRI and relaxometry

Coelho, Santiago ; Liao, Ying ; Szczepankiewicz, Filip LU orcid ; Veraart, Jelle ; Chung, Sohae ; Lui, Yvonne W. ; Novikov, Dmitry S. and Fieremans, Els (2024) In Human Brain Mapping 45(9).
Abstract

Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter (WM), we designed an optimal diffusion-relaxometry MRI protocol that samples multiple b-values, B-tensor shapes, and echo times (TE). This variable-TE protocol (27 min) has as subsets a fixed-TE protocol (15 min) and a two-shell dMRI protocol (7 min), both characterizing diffusion only. We assessed the sensitivity, specificity, and reproducibility of these protocols with synthetic experiments and in six healthy volunteers. Compared with the fixed-TE protocol, the variable-TE protocol enables estimation of the free water fraction while also capturing... (More)

Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter (WM), we designed an optimal diffusion-relaxometry MRI protocol that samples multiple b-values, B-tensor shapes, and echo times (TE). This variable-TE protocol (27 min) has as subsets a fixed-TE protocol (15 min) and a two-shell dMRI protocol (7 min), both characterizing diffusion only. We assessed the sensitivity, specificity, and reproducibility of these protocols with synthetic experiments and in six healthy volunteers. Compared with the fixed-TE protocol, the variable-TE protocol enables estimation of the free water fraction while also capturing compartmental (Formula presented.) relaxation times. Jointly measuring diffusion and relaxation offers increased sensitivity and specificity to microstructure parameters in brain WM with voxelwise coefficients of variation below 10%.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biophysical modeling, brain white matter, diffusion-relaxometry, microstructure imaging, multidimensional diffusion MRI, protocol optimization
in
Human Brain Mapping
volume
45
issue
9
article number
e26725
publisher
Wiley-Blackwell
external identifiers
  • scopus:85196646566
ISSN
1065-9471
DOI
10.1002/hbm.26725
language
English
LU publication?
yes
id
fbad9be5-b764-4155-91f6-6e4950b8861e
date added to LUP
2024-08-14 14:27:08
date last changed
2024-08-14 14:27:40
@article{fbad9be5-b764-4155-91f6-6e4950b8861e,
  abstract     = {{<p>Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter (WM), we designed an optimal diffusion-relaxometry MRI protocol that samples multiple b-values, B-tensor shapes, and echo times (TE). This variable-TE protocol (27 min) has as subsets a fixed-TE protocol (15 min) and a two-shell dMRI protocol (7 min), both characterizing diffusion only. We assessed the sensitivity, specificity, and reproducibility of these protocols with synthetic experiments and in six healthy volunteers. Compared with the fixed-TE protocol, the variable-TE protocol enables estimation of the free water fraction while also capturing compartmental (Formula presented.) relaxation times. Jointly measuring diffusion and relaxation offers increased sensitivity and specificity to microstructure parameters in brain WM with voxelwise coefficients of variation below 10%.</p>}},
  author       = {{Coelho, Santiago and Liao, Ying and Szczepankiewicz, Filip and Veraart, Jelle and Chung, Sohae and Lui, Yvonne W. and Novikov, Dmitry S. and Fieremans, Els}},
  issn         = {{1065-9471}},
  keywords     = {{biophysical modeling; brain white matter; diffusion-relaxometry; microstructure imaging; multidimensional diffusion MRI; protocol optimization}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{9}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Human Brain Mapping}},
  title        = {{Assessment of precision and accuracy of brain white matter microstructure using combined diffusion MRI and relaxometry}},
  url          = {{http://dx.doi.org/10.1002/hbm.26725}},
  doi          = {{10.1002/hbm.26725}},
  volume       = {{45}},
  year         = {{2024}},
}