Assessment of precision and accuracy of brain white matter microstructure using combined diffusion MRI and relaxometry
(2024) In Human Brain Mapping 45(9).- Abstract
Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter (WM), we designed an optimal diffusion-relaxometry MRI protocol that samples multiple b-values, B-tensor shapes, and echo times (TE). This variable-TE protocol (27 min) has as subsets a fixed-TE protocol (15 min) and a two-shell dMRI protocol (7 min), both characterizing diffusion only. We assessed the sensitivity, specificity, and reproducibility of these protocols with synthetic experiments and in six healthy volunteers. Compared with the fixed-TE protocol, the variable-TE protocol enables estimation of the free water fraction while also capturing... (More)
Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter (WM), we designed an optimal diffusion-relaxometry MRI protocol that samples multiple b-values, B-tensor shapes, and echo times (TE). This variable-TE protocol (27 min) has as subsets a fixed-TE protocol (15 min) and a two-shell dMRI protocol (7 min), both characterizing diffusion only. We assessed the sensitivity, specificity, and reproducibility of these protocols with synthetic experiments and in six healthy volunteers. Compared with the fixed-TE protocol, the variable-TE protocol enables estimation of the free water fraction while also capturing compartmental (Formula presented.) relaxation times. Jointly measuring diffusion and relaxation offers increased sensitivity and specificity to microstructure parameters in brain WM with voxelwise coefficients of variation below 10%.
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- author
- Coelho, Santiago ; Liao, Ying ; Szczepankiewicz, Filip LU ; Veraart, Jelle ; Chung, Sohae ; Lui, Yvonne W. ; Novikov, Dmitry S. and Fieremans, Els
- organization
- publishing date
- 2024-06-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biophysical modeling, brain white matter, diffusion-relaxometry, microstructure imaging, multidimensional diffusion MRI, protocol optimization
- in
- Human Brain Mapping
- volume
- 45
- issue
- 9
- article number
- e26725
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85196646566
- ISSN
- 1065-9471
- DOI
- 10.1002/hbm.26725
- language
- English
- LU publication?
- yes
- id
- fbad9be5-b764-4155-91f6-6e4950b8861e
- date added to LUP
- 2024-08-14 14:27:08
- date last changed
- 2024-08-14 14:27:40
@article{fbad9be5-b764-4155-91f6-6e4950b8861e, abstract = {{<p>Joint modeling of diffusion and relaxation has seen growing interest due to its potential to provide complementary information about tissue microstructure. For brain white matter (WM), we designed an optimal diffusion-relaxometry MRI protocol that samples multiple b-values, B-tensor shapes, and echo times (TE). This variable-TE protocol (27 min) has as subsets a fixed-TE protocol (15 min) and a two-shell dMRI protocol (7 min), both characterizing diffusion only. We assessed the sensitivity, specificity, and reproducibility of these protocols with synthetic experiments and in six healthy volunteers. Compared with the fixed-TE protocol, the variable-TE protocol enables estimation of the free water fraction while also capturing compartmental (Formula presented.) relaxation times. Jointly measuring diffusion and relaxation offers increased sensitivity and specificity to microstructure parameters in brain WM with voxelwise coefficients of variation below 10%.</p>}}, author = {{Coelho, Santiago and Liao, Ying and Szczepankiewicz, Filip and Veraart, Jelle and Chung, Sohae and Lui, Yvonne W. and Novikov, Dmitry S. and Fieremans, Els}}, issn = {{1065-9471}}, keywords = {{biophysical modeling; brain white matter; diffusion-relaxometry; microstructure imaging; multidimensional diffusion MRI; protocol optimization}}, language = {{eng}}, month = {{06}}, number = {{9}}, publisher = {{Wiley-Blackwell}}, series = {{Human Brain Mapping}}, title = {{Assessment of precision and accuracy of brain white matter microstructure using combined diffusion MRI and relaxometry}}, url = {{http://dx.doi.org/10.1002/hbm.26725}}, doi = {{10.1002/hbm.26725}}, volume = {{45}}, year = {{2024}}, }