Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
(2018) In Biomarker research 6(1).- Abstract
Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/fcb51ec9-a620-4ac8-a935-c57eb0d51fe8
- author
- Westhrin, Marita ; Moen, Siv Helen ; Kristensen, Ida Bruun ; Buene, Glenn ; Mylin, Anne Kærsgaard ; Turesson, Ingemar LU ; Abildgaard, Niels ; Waage, Anders and Standal, Therese
- publishing date
- 2018-06-14
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adipocyte, Chemerin, Multiple myeloma, Stromal cell
- in
- Biomarker research
- volume
- 6
- issue
- 1
- article number
- 21
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:29946468
- scopus:85062926743
- ISSN
- 2050-7771
- DOI
- 10.1186/s40364-018-0134-y
- language
- English
- LU publication?
- no
- id
- fcb51ec9-a620-4ac8-a935-c57eb0d51fe8
- date added to LUP
- 2019-04-01 10:09:39
- date last changed
- 2024-10-01 19:26:39
@article{fcb51ec9-a620-4ac8-a935-c57eb0d51fe8, abstract = {{<p>Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.</p>}}, author = {{Westhrin, Marita and Moen, Siv Helen and Kristensen, Ida Bruun and Buene, Glenn and Mylin, Anne Kærsgaard and Turesson, Ingemar and Abildgaard, Niels and Waage, Anders and Standal, Therese}}, issn = {{2050-7771}}, keywords = {{Adipocyte; Chemerin; Multiple myeloma; Stromal cell}}, language = {{eng}}, month = {{06}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{Biomarker research}}, title = {{Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes}}, url = {{http://dx.doi.org/10.1186/s40364-018-0134-y}}, doi = {{10.1186/s40364-018-0134-y}}, volume = {{6}}, year = {{2018}}, }