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Incidence and prevalence of multiple sclerosis in Malmö, Southern Sweden.

Alonso Magdalena, Lucia LU ; Zia, Elisabet LU ; Carmona i Codina, Olga ; Pessah, Helene LU and Sundström, Peter (2022) In Multiple sclerosis International p.1-7
Abstract
Objectives. To estimate the incidence and prevalence of multiple sclerosis (MS) in Malmö municipality in southwestern Sweden. Materials and Methods. Multiple sources were used in the case identification process. Case ascertainment was assessed by medical chart review including examinations such as magnetic resonance imaging, cerebrospinal fluid analyses, and relevant laboratory tests. Cases were classified according to the 2010 McDonald’s diagnostic criteria. Onset-adjusted prevalence and a definition of onset symptoms were applied. Results. The crude incidence of MS in 2001-2010 in Malmö municipality was 5.3/100,000 (95% confidence interval (CI): 4.5 to 6.2). There was a relapsing onset in 90.5% of cases. The female to male ratio was 1.8.... (More)
Objectives. To estimate the incidence and prevalence of multiple sclerosis (MS) in Malmö municipality in southwestern Sweden. Materials and Methods. Multiple sources were used in the case identification process. Case ascertainment was assessed by medical chart review including examinations such as magnetic resonance imaging, cerebrospinal fluid analyses, and relevant laboratory tests. Cases were classified according to the 2010 McDonald’s diagnostic criteria. Onset-adjusted prevalence and a definition of onset symptoms were applied. Results. The crude incidence of MS in 2001-2010 in Malmö municipality was 5.3/100,000 (95% confidence interval (CI): 4.5 to 6.2). There was a relapsing onset in 90.5% of cases. The female to male ratio was 1.8. The onset-adjusted prevalence for Dec 2010 was 133/100,000 (95% CI, 120 to 146) with a female to male ratio of 2.1. Conclusions. This is the first population-based epidemiological study in Skåne, the most southwestern part of Sweden showing a high incidence and prevalence. We found a lower incidence than expected according to previous nationwide figures, probably due to methodological differences between the studies. Our findings support the presence of a north-south gradient of MS prevalence in Sweden. (Less)
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type
Contribution to journal
publication status
published
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Multiple sclerosis International
article number
464370,
pages
1 - 7
DOI
10.1155/2022/5464370
language
English
LU publication?
yes
id
fce66ccd-a5b8-4f06-a816-72e8fc135edb
date added to LUP
2024-12-18 12:44:57
date last changed
2024-12-18 12:58:57
@article{fce66ccd-a5b8-4f06-a816-72e8fc135edb,
  abstract     = {{Objectives. To estimate the incidence and prevalence of multiple sclerosis (MS) in Malmö municipality in southwestern Sweden. Materials and Methods. Multiple sources were used in the case identification process. Case ascertainment was assessed by medical chart review including examinations such as magnetic resonance imaging, cerebrospinal fluid analyses, and relevant laboratory tests. Cases were classified according to the 2010 McDonald’s diagnostic criteria. Onset-adjusted prevalence and a definition of onset symptoms were applied. Results. The crude incidence of MS in 2001-2010 in Malmö municipality was 5.3/100,000 (95% confidence interval (CI): 4.5 to 6.2). There was a relapsing onset in 90.5% of cases. The female to male ratio was 1.8. The onset-adjusted prevalence for Dec 2010 was 133/100,000 (95% CI, 120 to 146) with a female to male ratio of 2.1. Conclusions. This is the first population-based epidemiological study in Skåne, the most southwestern part of Sweden showing a high incidence and prevalence. We found a lower incidence than expected according to previous nationwide figures, probably due to methodological differences between the studies. Our findings support the presence of a north-south gradient of MS prevalence in Sweden.}},
  author       = {{Alonso Magdalena, Lucia and Zia, Elisabet and Carmona i Codina, Olga and Pessah, Helene and Sundström, Peter}},
  language     = {{eng}},
  pages        = {{1--7}},
  series       = {{Multiple sclerosis International}},
  title        = {{Incidence and prevalence of multiple sclerosis in Malmö, Southern Sweden.}},
  url          = {{http://dx.doi.org/10.1155/2022/5464370}},
  doi          = {{10.1155/2022/5464370}},
  year         = {{2022}},
}