Interstitial laser hyperthermia of a rat liver adenocarcinoma
(2002) In Journal of X-Ray Science and Technology 10(3-4). p.177-185- Abstract
- The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was implanted into the left lateral lobe of the rat liver, and treatment was performed 8 days later. Rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection, with no difference in local control. Using inoculation of tumour cell suspensions into the lateral and the median lobes of the liver simultaneously and treating the lateral lobe tumour... (More)
- The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was implanted into the left lateral lobe of the rat liver, and treatment was performed 8 days later. Rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection, with no difference in local control. Using inoculation of tumour cell suspensions into the lateral and the median lobes of the liver simultaneously and treating the lateral lobe tumour only, we found that laser thermotherapy reduced take and growth of the untreated tumour in the median lobe indicating that laser thermotherapy may induce immunologic effects. It is concluded that interstitial laser thermotherapy reduces spread of liver tumour as compared to resection. It is suggested that this can be at least partly explained by a laser-induced immunologic effect. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124088
- author
- Tranberg, Karl-Göran LU ; Myllymäki, L ; Möller, P H ; Ivarsson, Kjell LU ; Sjögren, Hans Olov LU and Stenram, Unne LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of X-Ray Science and Technology
- volume
- 10
- issue
- 3-4
- pages
- 177 - 185
- publisher
- IOS Press
- external identifiers
-
- scopus:0036451658
- ISSN
- 0895-3996
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Surgery (Lund) (013009000), Neurosurgery (013026000)
- id
- 0002e863-685e-4d96-b259-38232c67b7c4 (old id 1124088)
- alternative location
- http://iospress.metapress.com/content/v21hjcxkgph0q0vf/
- date added to LUP
- 2016-04-01 17:00:05
- date last changed
- 2022-01-28 23:39:21
@article{0002e863-685e-4d96-b259-38232c67b7c4,
abstract = {{The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was implanted into the left lateral lobe of the rat liver, and treatment was performed 8 days later. Rats were treated with resection of the tumour-bearing lobe or underwent interstitial laser thermotherapy, which was performed at a steady-state temperature of 46°C for 30 min, 3 mm from the tumour margin. The incidence and extent of intraperitoneal spread was smaller after laser thermotherapy than after resection, with no difference in local control. Using inoculation of tumour cell suspensions into the lateral and the median lobes of the liver simultaneously and treating the lateral lobe tumour only, we found that laser thermotherapy reduced take and growth of the untreated tumour in the median lobe indicating that laser thermotherapy may induce immunologic effects. It is concluded that interstitial laser thermotherapy reduces spread of liver tumour as compared to resection. It is suggested that this can be at least partly explained by a laser-induced immunologic effect.}},
author = {{Tranberg, Karl-Göran and Myllymäki, L and Möller, P H and Ivarsson, Kjell and Sjögren, Hans Olov and Stenram, Unne}},
issn = {{0895-3996}},
language = {{eng}},
number = {{3-4}},
pages = {{177--185}},
publisher = {{IOS Press}},
series = {{Journal of X-Ray Science and Technology}},
title = {{Interstitial laser hyperthermia of a rat liver adenocarcinoma}},
url = {{http://iospress.metapress.com/content/v21hjcxkgph0q0vf/}},
volume = {{10}},
year = {{2002}},
}