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Components of the metabolic syndrome and colorectal cancer risk; a prospective study

Stocks, T. LU ; Lukanova, A.; Johansson, M. LU ; Rinaldi, S.; Palmqvist, R.; Hallmans, G.; Kaaks, R. and Stattin, P. (2008) In International Journal of Obesity 32(2). p.304-314
Abstract

Objective: To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer. Methods: We performed a case control study of 306 colorectal cancer cases and 595 matched controls nested in the Northern Sweden Health and Disease Cohort. Levels of C-peptide, glycated haemoglobin (HbA1c), leptin and adiponectin were measured in cryopreserved samples. Body mass index (BMI), systolic and diastolic blood pressure and fasting and post-load plasma glucose, had been measured in a subcohort. Conditional logistic regression was used to calculate odds ratios (OR) of disease, including risk assessments for the MetS factors: obesity (BMI>30 kg m-2),... (More)

Objective: To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer. Methods: We performed a case control study of 306 colorectal cancer cases and 595 matched controls nested in the Northern Sweden Health and Disease Cohort. Levels of C-peptide, glycated haemoglobin (HbA1c), leptin and adiponectin were measured in cryopreserved samples. Body mass index (BMI), systolic and diastolic blood pressure and fasting and post-load plasma glucose, had been measured in a subcohort. Conditional logistic regression was used to calculate odds ratios (OR) of disease, including risk assessments for the MetS factors: obesity (BMI>30 kg m-2), hypertension (blood pressure ≥140/90 mmHg or use of anti-hypertensive drugs) and hyperglycaemia (fasting glucose ≥6.1 mmol l-1 or post-load glucose in capillary plasma ≥8.9 mmol l-1). Results: None of the studied variables were significantly associated with risk across quartiles. Presence of obesity, hypertension and hyperglycaemia significantly increased the risk of colorectal cancer; OR for three vs null factors was 2.57 (95% Confidence Interval [CI] 1.20-5.52; P trend=0.0021), as compared to a 30 to 70% increased risk for the factors in single. Similarly, top decile levels of C-peptide, HbA1c and leptin/adiponectin ratio were associated with an increased risk; ORs for top vs deciles 1-9 were 1.56 (95% CI 0.93-2.62; P=0.090), 1.83 (95% CI 1.00-3.36; P=0.051) and 1.50 (95% CI 0.83-2.71; P=0.18), respectively. Conclusions: Our study support the view that components of the MetS increase risk of colorectal cancer, and further suggests that only very high levels of metabolic factors confer an increased risk.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood glucose, C-peptide, Colorectal neoplasms, Insulin resistance, Leptin
in
International Journal of Obesity
volume
32
issue
2
pages
11 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:39449120246
ISSN
0307-0565
DOI
10.1038/sj.ijo.0803713
language
English
LU publication?
no
id
003ca8d6-3fe1-4f73-a94c-ff8094ed3838
date added to LUP
2019-05-31 09:22:54
date last changed
2019-10-15 07:07:09
@article{003ca8d6-3fe1-4f73-a94c-ff8094ed3838,
  abstract     = {<p>Objective: To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer. Methods: We performed a case control study of 306 colorectal cancer cases and 595 matched controls nested in the Northern Sweden Health and Disease Cohort. Levels of C-peptide, glycated haemoglobin (HbA1c), leptin and adiponectin were measured in cryopreserved samples. Body mass index (BMI), systolic and diastolic blood pressure and fasting and post-load plasma glucose, had been measured in a subcohort. Conditional logistic regression was used to calculate odds ratios (OR) of disease, including risk assessments for the MetS factors: obesity (BMI&gt;30 kg m<sup>-2</sup>), hypertension (blood pressure ≥140/90 mmHg or use of anti-hypertensive drugs) and hyperglycaemia (fasting glucose ≥6.1 mmol l<sup>-1</sup> or post-load glucose in capillary plasma ≥8.9 mmol l<sup>-1</sup>). Results: None of the studied variables were significantly associated with risk across quartiles. Presence of obesity, hypertension and hyperglycaemia significantly increased the risk of colorectal cancer; OR for three vs null factors was 2.57 (95% Confidence Interval [CI] 1.20-5.52; P <sub>trend</sub>=0.0021), as compared to a 30 to 70% increased risk for the factors in single. Similarly, top decile levels of C-peptide, HbA1c and leptin/adiponectin ratio were associated with an increased risk; ORs for top vs deciles 1-9 were 1.56 (95% CI 0.93-2.62; P=0.090), 1.83 (95% CI 1.00-3.36; P=0.051) and 1.50 (95% CI 0.83-2.71; P=0.18), respectively. Conclusions: Our study support the view that components of the MetS increase risk of colorectal cancer, and further suggests that only very high levels of metabolic factors confer an increased risk.</p>},
  author       = {Stocks, T. and Lukanova, A. and Johansson, M. and Rinaldi, S. and Palmqvist, R. and Hallmans, G. and Kaaks, R. and Stattin, P.},
  issn         = {0307-0565},
  keyword      = {Blood glucose,C-peptide,Colorectal neoplasms,Insulin resistance,Leptin},
  language     = {eng},
  month        = {02},
  number       = {2},
  pages        = {304--314},
  publisher    = {Nature Publishing Group},
  series       = {International Journal of Obesity},
  title        = {Components of the metabolic syndrome and colorectal cancer risk; a prospective study},
  url          = {http://dx.doi.org/10.1038/sj.ijo.0803713},
  volume       = {32},
  year         = {2008},
}