Components of the metabolic syndrome and colorectal cancer risk; a prospective study
(2008) In International Journal of Obesity 32(2). p.304-314- Abstract
Objective: To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer. Methods: We performed a case control study of 306 colorectal cancer cases and 595 matched controls nested in the Northern Sweden Health and Disease Cohort. Levels of C-peptide, glycated haemoglobin (HbA1c), leptin and adiponectin were measured in cryopreserved samples. Body mass index (BMI), systolic and diastolic blood pressure and fasting and post-load plasma glucose, had been measured in a subcohort. Conditional logistic regression was used to calculate odds ratios (OR) of disease, including risk assessments for the MetS factors: obesity (BMI>30 kg m-2),... (More)
Objective: To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer. Methods: We performed a case control study of 306 colorectal cancer cases and 595 matched controls nested in the Northern Sweden Health and Disease Cohort. Levels of C-peptide, glycated haemoglobin (HbA1c), leptin and adiponectin were measured in cryopreserved samples. Body mass index (BMI), systolic and diastolic blood pressure and fasting and post-load plasma glucose, had been measured in a subcohort. Conditional logistic regression was used to calculate odds ratios (OR) of disease, including risk assessments for the MetS factors: obesity (BMI>30 kg m-2), hypertension (blood pressure ≥140/90 mmHg or use of anti-hypertensive drugs) and hyperglycaemia (fasting glucose ≥6.1 mmol l-1 or post-load glucose in capillary plasma ≥8.9 mmol l-1). Results: None of the studied variables were significantly associated with risk across quartiles. Presence of obesity, hypertension and hyperglycaemia significantly increased the risk of colorectal cancer; OR for three vs null factors was 2.57 (95% Confidence Interval [CI] 1.20-5.52; P trend=0.0021), as compared to a 30 to 70% increased risk for the factors in single. Similarly, top decile levels of C-peptide, HbA1c and leptin/adiponectin ratio were associated with an increased risk; ORs for top vs deciles 1-9 were 1.56 (95% CI 0.93-2.62; P=0.090), 1.83 (95% CI 1.00-3.36; P=0.051) and 1.50 (95% CI 0.83-2.71; P=0.18), respectively. Conclusions: Our study support the view that components of the MetS increase risk of colorectal cancer, and further suggests that only very high levels of metabolic factors confer an increased risk.
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- author
- Stocks, T. LU ; Lukanova, A. ; Johansson, M. LU ; Rinaldi, S. ; Palmqvist, R. ; Hallmans, G. ; Kaaks, R. and Stattin, P.
- publishing date
- 2008-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Blood glucose, C-peptide, Colorectal neoplasms, Insulin resistance, Leptin
- in
- International Journal of Obesity
- volume
- 32
- issue
- 2
- pages
- 11 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:17878894
- scopus:39449120246
- ISSN
- 0307-0565
- DOI
- 10.1038/sj.ijo.0803713
- language
- English
- LU publication?
- no
- id
- 003ca8d6-3fe1-4f73-a94c-ff8094ed3838
- date added to LUP
- 2019-05-31 09:22:54
- date last changed
- 2024-09-04 22:16:54
@article{003ca8d6-3fe1-4f73-a94c-ff8094ed3838, abstract = {{<p>Objective: To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer. Methods: We performed a case control study of 306 colorectal cancer cases and 595 matched controls nested in the Northern Sweden Health and Disease Cohort. Levels of C-peptide, glycated haemoglobin (HbA1c), leptin and adiponectin were measured in cryopreserved samples. Body mass index (BMI), systolic and diastolic blood pressure and fasting and post-load plasma glucose, had been measured in a subcohort. Conditional logistic regression was used to calculate odds ratios (OR) of disease, including risk assessments for the MetS factors: obesity (BMI>30 kg m<sup>-2</sup>), hypertension (blood pressure ≥140/90 mmHg or use of anti-hypertensive drugs) and hyperglycaemia (fasting glucose ≥6.1 mmol l<sup>-1</sup> or post-load glucose in capillary plasma ≥8.9 mmol l<sup>-1</sup>). Results: None of the studied variables were significantly associated with risk across quartiles. Presence of obesity, hypertension and hyperglycaemia significantly increased the risk of colorectal cancer; OR for three vs null factors was 2.57 (95% Confidence Interval [CI] 1.20-5.52; P <sub>trend</sub>=0.0021), as compared to a 30 to 70% increased risk for the factors in single. Similarly, top decile levels of C-peptide, HbA1c and leptin/adiponectin ratio were associated with an increased risk; ORs for top vs deciles 1-9 were 1.56 (95% CI 0.93-2.62; P=0.090), 1.83 (95% CI 1.00-3.36; P=0.051) and 1.50 (95% CI 0.83-2.71; P=0.18), respectively. Conclusions: Our study support the view that components of the MetS increase risk of colorectal cancer, and further suggests that only very high levels of metabolic factors confer an increased risk.</p>}}, author = {{Stocks, T. and Lukanova, A. and Johansson, M. and Rinaldi, S. and Palmqvist, R. and Hallmans, G. and Kaaks, R. and Stattin, P.}}, issn = {{0307-0565}}, keywords = {{Blood glucose; C-peptide; Colorectal neoplasms; Insulin resistance; Leptin}}, language = {{eng}}, month = {{02}}, number = {{2}}, pages = {{304--314}}, publisher = {{Nature Publishing Group}}, series = {{International Journal of Obesity}}, title = {{Components of the metabolic syndrome and colorectal cancer risk; a prospective study}}, url = {{http://dx.doi.org/10.1038/sj.ijo.0803713}}, doi = {{10.1038/sj.ijo.0803713}}, volume = {{32}}, year = {{2008}}, }