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Risk of breast cancer in relation to dietary intake of selenium and serum selenium as a marker of dietary intake: a prospective cohort study within The Malmö Diet and Cancer Study

Bengtsson, Ylva LU orcid ; Sandsveden, Malte LU and Manjer, Jonas LU (2021) In Cancer Causes and Control 32(8). p.815-826
Abstract
Purpose
Selenium has been suggested to be protective against breast cancer, but the evidence remains inconclusive. Hence, it is important to further examine the potential protective effect. This prospective cohort study investigates pre-diagnostic selenium intake in relation to breast cancer risk. In addition, we analyze serum selenium as a marker of dietary intake.
Methods
This study includes 17,035 women in the Malmö Diet and Cancer cohort. Dietary assessment and serum samples were collected at baseline (1991–1996). During 344,584 person-years of follow-up, 1,427 incident cases were retrieved. Cox regression analysis examined breast cancer risks adjusted for potential confounding factors. In addition, odds ratios (ORs) were... (More)
Purpose
Selenium has been suggested to be protective against breast cancer, but the evidence remains inconclusive. Hence, it is important to further examine the potential protective effect. This prospective cohort study investigates pre-diagnostic selenium intake in relation to breast cancer risk. In addition, we analyze serum selenium as a marker of dietary intake.
Methods
This study includes 17,035 women in the Malmö Diet and Cancer cohort. Dietary assessment and serum samples were collected at baseline (1991–1996). During 344,584 person-years of follow-up, 1,427 incident cases were retrieved. Cox regression analysis examined breast cancer risks adjusted for potential confounding factors. In addition, odds ratios (ORs) were estimated for 1186 cases and an equal number of controls in relation to quartiles (Q) of selenium intake and groups consisting of a combination of intake and serum selenium levels.
Results
No overall association between selenium intake, or a combination of intake and serum levels, and breast cancer risk was found. The adjusted relative risk for breast cancer in selenium intake Q4 versus Q1 was 0.96 (0.83–1.12) (Ptrend = 0.65). Similarly, adjusted the OR for breast cancer in selenium intake for Q4 versus Q1 was 0.97 (0.76–1.23). The kappa value, 0.096 (p = 0.001), showed poor agreement between serum selenium and selenium intake.
Conclusion
Our findings suggest that there is no overall association between selenium intake, or a combination of intake and serum levels, and breast cancer risk. Finally, our results showed a poor correlation between estimated selenium intake and serum selenium. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Causes and Control
volume
32
issue
8
pages
12 pages
publisher
Springer
external identifiers
  • pmid:33914217
  • scopus:85105425906
ISSN
1573-7225
DOI
10.1007/s10552-021-01433-1
project
Trace Elements and Breast Cancer: Selenium, Zinc and Copper in Relation to Risk and Prognosis
language
English
LU publication?
yes
id
00589892-6ddf-4b39-9acd-2373047ada7c
date added to LUP
2021-05-07 14:32:56
date last changed
2023-09-12 19:23:09
@article{00589892-6ddf-4b39-9acd-2373047ada7c,
  abstract     = {{Purpose<br/>Selenium has been suggested to be protective against breast cancer, but the evidence remains inconclusive. Hence, it is important to further examine the potential protective effect. This prospective cohort study investigates pre-diagnostic selenium intake in relation to breast cancer risk. In addition, we analyze serum selenium as a marker of dietary intake.<br/>Methods<br/>This study includes 17,035 women in the Malmö Diet and Cancer cohort. Dietary assessment and serum samples were collected at baseline (1991–1996). During 344,584 person-years of follow-up, 1,427 incident cases were retrieved. Cox regression analysis examined breast cancer risks adjusted for potential confounding factors. In addition, odds ratios (ORs) were estimated for 1186 cases and an equal number of controls in relation to quartiles (Q) of selenium intake and groups consisting of a combination of intake and serum selenium levels.<br/>Results<br/>No overall association between selenium intake, or a combination of intake and serum levels, and breast cancer risk was found. The adjusted relative risk for breast cancer in selenium intake Q4 versus Q1 was 0.96 (0.83–1.12) (Ptrend = 0.65). Similarly, adjusted the OR for breast cancer in selenium intake for Q4 versus Q1 was 0.97 (0.76–1.23). The kappa value, 0.096 (p = 0.001), showed poor agreement between serum selenium and selenium intake.<br/>Conclusion<br/>Our findings suggest that there is no overall association between selenium intake, or a combination of intake and serum levels, and breast cancer risk. Finally, our results showed a poor correlation between estimated selenium intake and serum selenium.}},
  author       = {{Bengtsson, Ylva and Sandsveden, Malte and Manjer, Jonas}},
  issn         = {{1573-7225}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{815--826}},
  publisher    = {{Springer}},
  series       = {{Cancer Causes and Control}},
  title        = {{Risk of breast cancer in relation to dietary intake of selenium and serum selenium as a marker of dietary intake: a prospective cohort study within The Malmö Diet and Cancer Study}},
  url          = {{http://dx.doi.org/10.1007/s10552-021-01433-1}},
  doi          = {{10.1007/s10552-021-01433-1}},
  volume       = {{32}},
  year         = {{2021}},
}