Head-to-head comparison of left ventricular volumes and ejection fraction by [13N]ammonia positron emission tomography, myocardial perfusion single-photon emission computed tomography with cadmium-zinc-telluride technology and cardiac magnetic resonance imaging
Hedeer, Fredrik LU ; Kvernby, Sofia LU
; Oddstig, Jenny
LU
and Engblom, Shahnaz Akil
(2026)
In Journal of Nuclear Cardiology
55.
- Abstract
Background Assessment of left ventricular function and dimensions is central for cardiac diagnostic imaging with cardiac positron emission tomography (PET) and myocardial perfusion single-photon emission computed tomography (MPS). The aim of this study was to compare [13N]NH3 PET and MPS, head-to-head, for assessment of left ventricular ejection fraction (LVEF) and volumes using cardiac magnetic resonance (CMR) as reference. Methods A total of 74 patients with suspected chronic coronary syndrome, of which 27 patients were examined twice 6 months apart, were included. All performed CMR and [13N]NH3 PET on the same day, and MPS with cadmium-zinc-telluride technology within 1.0 ± 1.8 days. LVEF,... (More)
Background Assessment of left ventricular function and dimensions is central for cardiac diagnostic imaging with cardiac positron emission tomography (PET) and myocardial perfusion single-photon emission computed tomography (MPS). The aim of this study was to compare [13N]NH3 PET and MPS, head-to-head, for assessment of left ventricular ejection fraction (LVEF) and volumes using cardiac magnetic resonance (CMR) as reference. Methods A total of 74 patients with suspected chronic coronary syndrome, of which 27 patients were examined twice 6 months apart, were included. All performed CMR and [13N]NH3 PET on the same day, and MPS with cadmium-zinc-telluride technology within 1.0 ± 1.8 days. LVEF, end-diastolic volume (EDV) and end-systolic volume (ESV) by [13N]NH3 PET and MPS using standard clinical reconstruction parameters as well as reconstructions with altered filters, subsets, and iterations were compared to CMR (bias±standard deviation). Results Using standard clinical reconstruction parameters, both PET and MPS underestimated EDV (−58 ± 23 mL and −77 ± 22 mL, respectively) and ESV (−31 ± 19 mL and −29 ± 16 mL, respectively) compared to CMR. For LVEF, the bias was 5±6% and −3±7% for PET and MPS, respectively. The bias was slightly lowered for EDV by altering reconstruction parameters of PET (−56 ± 23 mL) and MPS (−76 ± 23 mL) images. Conclusions Left ventricular volumes by [13N]NH3 PET and MPS are significantly underestimated compared to CMR when using standard clinical reconstruction parameters, whereas LVEF shows better agreement. Furthermore, there seems to be potential for improved accuracy of EDV, especially for [13N]NH3 PET, when optimizing selected reconstruction parameters in the studied population.
(Less)
- author
- Hedeer, Fredrik
LU
; Kvernby, Sofia
LU
; Oddstig, Jenny
LU
and Engblom, Shahnaz Akil
- organization
- publishing date
- 2026-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiac magnetic resonance imaging, Cardiac positron emission tomography, Left ventricular ejection fraction, Left ventricular volumes, Myocardial perfusion single-photon emission computed tomography
- in
- Journal of Nuclear Cardiology
- volume
- 55
- article number
- 102542
- publisher
- Springer
- external identifiers
-
- pmid:41207469
- scopus:105025141858
- ISSN
- 1071-3581
- DOI
- 10.1016/j.nuclcard.2025.102542
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2025 The Author(s).
- id
- 00bb5135-806c-4d06-a1a7-1d2ce27fde21
- date added to LUP
- 2026-02-27 13:36:04
- date last changed
- 2026-02-27 13:37:20
@article{00bb5135-806c-4d06-a1a7-1d2ce27fde21,
abstract = {{<p>Background Assessment of left ventricular function and dimensions is central for cardiac diagnostic imaging with cardiac positron emission tomography (PET) and myocardial perfusion single-photon emission computed tomography (MPS). The aim of this study was to compare [<sup>13</sup>N]NH<sub>3</sub> PET and MPS, head-to-head, for assessment of left ventricular ejection fraction (LVEF) and volumes using cardiac magnetic resonance (CMR) as reference. Methods A total of 74 patients with suspected chronic coronary syndrome, of which 27 patients were examined twice 6 months apart, were included. All performed CMR and [<sup>13</sup>N]NH<sub>3</sub> PET on the same day, and MPS with cadmium-zinc-telluride technology within 1.0 ± 1.8 days. LVEF, end-diastolic volume (EDV) and end-systolic volume (ESV) by [<sup>13</sup>N]NH<sub>3</sub> PET and MPS using standard clinical reconstruction parameters as well as reconstructions with altered filters, subsets, and iterations were compared to CMR (bias±standard deviation). Results Using standard clinical reconstruction parameters, both PET and MPS underestimated EDV (−58 ± 23 mL and −77 ± 22 mL, respectively) and ESV (−31 ± 19 mL and −29 ± 16 mL, respectively) compared to CMR. For LVEF, the bias was 5±6% and −3±7% for PET and MPS, respectively. The bias was slightly lowered for EDV by altering reconstruction parameters of PET (−56 ± 23 mL) and MPS (−76 ± 23 mL) images. Conclusions Left ventricular volumes by [<sup>13</sup>N]NH<sub>3</sub> PET and MPS are significantly underestimated compared to CMR when using standard clinical reconstruction parameters, whereas LVEF shows better agreement. Furthermore, there seems to be potential for improved accuracy of EDV, especially for [<sup>13</sup>N]NH<sub>3</sub> PET, when optimizing selected reconstruction parameters in the studied population.</p>}},
author = {{Hedeer, Fredrik and Kvernby, Sofia and Oddstig, Jenny and Engblom, Shahnaz Akil}},
issn = {{1071-3581}},
keywords = {{Cardiac magnetic resonance imaging; Cardiac positron emission tomography; Left ventricular ejection fraction; Left ventricular volumes; Myocardial perfusion single-photon emission computed tomography}},
language = {{eng}},
publisher = {{Springer}},
series = {{Journal of Nuclear Cardiology}},
title = {{Head-to-head comparison of left ventricular volumes and ejection fraction by [<sup>13</sup>N]ammonia positron emission tomography, myocardial perfusion single-photon emission computed tomography with cadmium-zinc-telluride technology and cardiac magnetic resonance imaging}},
url = {{http://dx.doi.org/10.1016/j.nuclcard.2025.102542}},
doi = {{10.1016/j.nuclcard.2025.102542}},
volume = {{55}},
year = {{2026}},
}