Selective increase of the contractile response to endothelin-1 in subcutaneous arteries from patients with essential hypertension
Lind, Henrik ; Adner, Mikael LU ; Erlinge, David LU
; Brunkwall, Jan
and Edvinsson, Lars
LU
(1999)
In Blood Pressure
8(1).
p.9-15
- Abstract
- Endothelin-1 has been shown to contribute to basal vascular tone in man. Since endothelin-1 is a potent vasoconstrictor putatively involved in hypertension, we have compared the contractile responses of endothelin-1 and noradrenaline in relation to potassium chloride in subcutaneous resistance arteries from subjects with established essential hypertension with matched controls. Furthermore, with RT-PCR, the occurrence of mRNA for the ETA and ET(B) receptors was shown in the tunica media layer of subcutaneous arteries in controls and hypertensives. The maximum contractile response to endothelin-1 was significantly higher in the subcutaneous arteries of the hypertensives (by 88% with no change in potency) as compared to controls. The... (More)
- Endothelin-1 has been shown to contribute to basal vascular tone in man. Since endothelin-1 is a potent vasoconstrictor putatively involved in hypertension, we have compared the contractile responses of endothelin-1 and noradrenaline in relation to potassium chloride in subcutaneous resistance arteries from subjects with established essential hypertension with matched controls. Furthermore, with RT-PCR, the occurrence of mRNA for the ETA and ET(B) receptors was shown in the tunica media layer of subcutaneous arteries in controls and hypertensives. The maximum contractile response to endothelin-1 was significantly higher in the subcutaneous arteries of the hypertensives (by 88% with no change in potency) as compared to controls. The responses to noradrenaline, acetylcholine and potassium chloride did not differ between the groups. This selective increase in the contractile response to endothelin-1 might contribute to the development of essential hypertension. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1114827
- author
- Lind, Henrik
; Adner, Mikael
LU
; Erlinge, David
LU
; Brunkwall, Jan
and Edvinsson, Lars
LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acetylcholine, endothelin-1, essential hypertension, noradrenaline, potassium
- in
- Blood Pressure
- volume
- 8
- issue
- 1
- pages
- 9 - 15
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:10412877
- scopus:0033029044
- ISSN
- 0803-7051
- DOI
- 10.1080/080370599439742
- language
- English
- LU publication?
- yes
- id
- 00e09ff3-d899-4859-82f2-bab2f96c7ab2 (old id 1114827)
- date added to LUP
- 2016-04-01 11:58:04
- date last changed
- 2024-01-08 03:11:15
@article{00e09ff3-d899-4859-82f2-bab2f96c7ab2,
abstract = {{Endothelin-1 has been shown to contribute to basal vascular tone in man. Since endothelin-1 is a potent vasoconstrictor putatively involved in hypertension, we have compared the contractile responses of endothelin-1 and noradrenaline in relation to potassium chloride in subcutaneous resistance arteries from subjects with established essential hypertension with matched controls. Furthermore, with RT-PCR, the occurrence of mRNA for the ETA and ET(B) receptors was shown in the tunica media layer of subcutaneous arteries in controls and hypertensives. The maximum contractile response to endothelin-1 was significantly higher in the subcutaneous arteries of the hypertensives (by 88% with no change in potency) as compared to controls. The responses to noradrenaline, acetylcholine and potassium chloride did not differ between the groups. This selective increase in the contractile response to endothelin-1 might contribute to the development of essential hypertension.}},
author = {{Lind, Henrik and Adner, Mikael and Erlinge, David and Brunkwall, Jan and Edvinsson, Lars}},
issn = {{0803-7051}},
keywords = {{acetylcholine; endothelin-1; essential
hypertension; noradrenaline; potassium}},
language = {{eng}},
number = {{1}},
pages = {{9--15}},
publisher = {{Taylor & Francis}},
series = {{Blood Pressure}},
title = {{Selective increase of the contractile response to endothelin-1 in subcutaneous arteries from patients with essential hypertension}},
url = {{http://dx.doi.org/10.1080/080370599439742}},
doi = {{10.1080/080370599439742}},
volume = {{8}},
year = {{1999}},
}