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Use of Oral Contraceptives and Breast Cancer Survival

Nilsson, Emelie LU ; Olsson, Stina ; Thorlacius, Henrik LU and Butt, Salma LU (2016) In International Journal of Womens Health and Wellness 2(4).
Abstract
Introduction: Oral contraceptives (OC) have been shown to give a transient increased breast cancer risk. However, studies on breast cancer survival after OC use are sparse and conflicting.
Aim: The aim of this study was to examine previous use of OC in relation to survival after breast cancer diagnosis.
Methods: Data was collected from Malmö Diet and Cancer Study, with baseline examinations between 1991 and 1996. Out of 17035 women who completed all study parts, 765 women with incident breast cancer were included in this study. Kaplan Meier and Cox Proportional Hazards analyses, with 95% confidence intervals (CI), were used to study OC in relation to breast cancer-specific and overall survival. All analyses were stratified on age... (More)
Introduction: Oral contraceptives (OC) have been shown to give a transient increased breast cancer risk. However, studies on breast cancer survival after OC use are sparse and conflicting.
Aim: The aim of this study was to examine previous use of OC in relation to survival after breast cancer diagnosis.
Methods: Data was collected from Malmö Diet and Cancer Study, with baseline examinations between 1991 and 1996. Out of 17035 women who completed all study parts, 765 women with incident breast cancer were included in this study. Kaplan Meier and Cox Proportional Hazards analyses, with 95% confidence intervals (CI), were used to study OC in relation to breast cancer-specific and overall survival. All analyses were stratified on age at diagnosis.
Results: Women who had ever used OC were younger and more often had grade III tumors than those who had never used OC. Breast cancer-specific survival in women who ever had used OC was better when adjusting for BMI, socioeconomic status as well as tumor characteristics. However, when adjusting for age at diagnosis, the results did not remain significant (0.68, CI 95% 0.39- 1.18). Stratified analyses on age at diagnosis (40-55, 56-70 and ≥ 71) showed no statistically significant associations.
Conclusion: In this study we could not demonstrate a significant effect of OC use on breast cancer survival. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Womens Health and Wellness
volume
2
issue
4
publisher
ClinMed International Library
ISSN
2474-1353
DOI
10.23937/2474-1353/1510039
language
English
LU publication?
yes
id
00f57d5f-b864-4fb7-b964-5749f3aaae44
date added to LUP
2020-01-24 12:31:14
date last changed
2020-01-27 10:46:53
@article{00f57d5f-b864-4fb7-b964-5749f3aaae44,
  abstract     = {{Introduction: Oral contraceptives (OC) have been shown to give a transient increased breast cancer risk. However, studies on breast cancer survival after OC use are sparse and conflicting.<br/>Aim: The aim of this study was to examine previous use of OC in relation to survival after breast cancer diagnosis.<br/>Methods: Data was collected from Malmö Diet and Cancer Study, with baseline examinations between 1991 and 1996. Out of 17035 women who completed all study parts, 765 women with incident breast cancer were included in this study. Kaplan Meier and Cox Proportional Hazards analyses, with 95% confidence intervals (CI), were used to study OC in relation to breast cancer-specific and overall survival. All analyses were stratified on age at diagnosis.<br/>Results: Women who had ever used OC were younger and more often had grade III tumors than those who had never used OC. Breast cancer-specific survival in women who ever had used OC was better when adjusting for BMI, socioeconomic status as well as tumor characteristics. However, when adjusting for age at diagnosis, the results did not remain significant (0.68, CI 95% 0.39- 1.18). Stratified analyses on age at diagnosis (40-55, 56-70 and ≥ 71) showed no statistically significant associations.<br/>Conclusion: In this study we could not demonstrate a significant effect of OC use on breast cancer survival.}},
  author       = {{Nilsson, Emelie and Olsson, Stina and Thorlacius, Henrik and Butt, Salma}},
  issn         = {{2474-1353}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{ClinMed International Library}},
  series       = {{International Journal of Womens Health and Wellness}},
  title        = {{Use of Oral Contraceptives and Breast Cancer Survival}},
  url          = {{http://dx.doi.org/10.23937/2474-1353/1510039}},
  doi          = {{10.23937/2474-1353/1510039}},
  volume       = {{2}},
  year         = {{2016}},
}