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On the stability of lithocholate derivative supramolecular tubules

Gubitosi, M. LU ; D'Annibale, Andrea; Schillén, K. LU ; Olsson, U. LU ; Pavel, Nicolae V. and Galantini, Luciano (2017) In RSC Advances 7(1). p.512-517
Abstract

The self-assembly of a mannose-labelled bile salt derivative gives rise to a metastable nematic phase of monodisperse nanotubes in aqueous solutions that are characterized by a crystalline order. This work is addressed to study the relative stability of these tubular aggregates in order to have full control of such a system for possible applications. By using a static light scattering method we evaluate both the solubilities of the metastable nanotubes and of stable nanocrystals, demonstrating that these are remarkably lower than the critical micellar concentration of typical bile salts and other ionic conventional surfactants. A partial stability map is developed by combining solubility and calorimetry data, where a nematic nanotube... (More)

The self-assembly of a mannose-labelled bile salt derivative gives rise to a metastable nematic phase of monodisperse nanotubes in aqueous solutions that are characterized by a crystalline order. This work is addressed to study the relative stability of these tubular aggregates in order to have full control of such a system for possible applications. By using a static light scattering method we evaluate both the solubilities of the metastable nanotubes and of stable nanocrystals, demonstrating that these are remarkably lower than the critical micellar concentration of typical bile salts and other ionic conventional surfactants. A partial stability map is developed by combining solubility and calorimetry data, where a nematic nanotube phase region is highlighted below 60-65 °C.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
RSC Advances
volume
7
issue
1
pages
6 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85008440736
  • wos:000393741900067
ISSN
2046-2069
DOI
10.1039/c6ra26092f
language
English
LU publication?
yes
id
014ce84b-b8d0-44c2-bb56-8612cb5644c7
date added to LUP
2017-03-17 11:18:31
date last changed
2018-04-29 04:37:16
@article{014ce84b-b8d0-44c2-bb56-8612cb5644c7,
  abstract     = {<p>The self-assembly of a mannose-labelled bile salt derivative gives rise to a metastable nematic phase of monodisperse nanotubes in aqueous solutions that are characterized by a crystalline order. This work is addressed to study the relative stability of these tubular aggregates in order to have full control of such a system for possible applications. By using a static light scattering method we evaluate both the solubilities of the metastable nanotubes and of stable nanocrystals, demonstrating that these are remarkably lower than the critical micellar concentration of typical bile salts and other ionic conventional surfactants. A partial stability map is developed by combining solubility and calorimetry data, where a nematic nanotube phase region is highlighted below 60-65 °C.</p>},
  author       = {Gubitosi, M. and D'Annibale, Andrea and Schillén, K. and Olsson, U. and Pavel, Nicolae V. and Galantini, Luciano},
  issn         = {2046-2069},
  language     = {eng},
  number       = {1},
  pages        = {512--517},
  publisher    = {Royal Society of Chemistry},
  series       = {RSC Advances},
  title        = {On the stability of lithocholate derivative supramolecular tubules},
  url          = {http://dx.doi.org/10.1039/c6ra26092f},
  volume       = {7},
  year         = {2017},
}