EndoCompass project : research roadmap for endocrine causes and consequences of cancer
(2025) In European Journal of Endocrinology 193(Supplement_2). p.35-46- Abstract
Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology—aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods: Research priorities... (More)
Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology—aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. Results: Research priorities encompass re-evaluation of progestins in breast cancer treatment; strategies to disrupt AR signalling in prostate cancer; surveillance for endocrine sequelae in childhood cancer survivors; understanding genotoxic effects on fertility; and management of checkpoint inhibitor endocrinopathies and familial cancer syndromes. Emphasis is placed on precision medicine and metabolic factors in cancer. Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into cancer-endocrine pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.
(Less)
- author
- organization
- publishing date
- 2025-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cancer syndrome, EndoCompass, endocrine-related cancer, funding, roadmap
- in
- European Journal of Endocrinology
- volume
- 193
- issue
- Supplement_2
- pages
- 35 - 46
- publisher
- Society of the European Journal of Endocrinology
- external identifiers
-
- pmid:41104473
- scopus:105019114419
- ISSN
- 0804-4643
- DOI
- 10.1093/ejendo/lvaf066
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.
- id
- 015efcec-5ab7-4eed-a2d9-982b996a217e
- date added to LUP
- 2025-12-18 10:30:20
- date last changed
- 2025-12-18 10:30:55
@article{015efcec-5ab7-4eed-a2d9-982b996a217e,
abstract = {{<p>Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology—aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. Results: Research priorities encompass re-evaluation of progestins in breast cancer treatment; strategies to disrupt AR signalling in prostate cancer; surveillance for endocrine sequelae in childhood cancer survivors; understanding genotoxic effects on fertility; and management of checkpoint inhibitor endocrinopathies and familial cancer syndromes. Emphasis is placed on precision medicine and metabolic factors in cancer. Conclusions: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into cancer-endocrine pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.</p>}},
author = {{Carroll, Jason S. and Castinetti, Frederic and Follin, Cecilia and Luque, Raul M. and Verrijn Stuart, Annemarie A. and Giwercman, Aleksander and Grozinsky-Glasberg, Simona and Krausz, Csilla and Paschou, Stavroula A. and Peeters, Robin and Pieterman, Carolina R.C. and Romanet, Pauline and Jiménez-Vacas, Juan M. and van Santen, Hanneke M. and Zibar Tomšic, Karin}},
issn = {{0804-4643}},
keywords = {{cancer syndrome; EndoCompass; endocrine-related cancer; funding; roadmap}},
language = {{eng}},
month = {{10}},
number = {{Supplement_2}},
pages = {{35--46}},
publisher = {{Society of the European Journal of Endocrinology}},
series = {{European Journal of Endocrinology}},
title = {{EndoCompass project : research roadmap for endocrine causes and consequences of cancer}},
url = {{http://dx.doi.org/10.1093/ejendo/lvaf066}},
doi = {{10.1093/ejendo/lvaf066}},
volume = {{193}},
year = {{2025}},
}