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The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival : the Malmö Diet and Cancer Study

Sartor, Hanna LU ; Brandt, Jasmine LU ; Grassmann, Felix ; Eriksson, Mikael ; Czene, Kamila ; Melander, Olle LU orcid and Zackrisson, Sophia LU (2020) In Acta Radiologica 61(10). p.1326-1334
Abstract

Background: Genetic factors are important in determining breast density, and heritable factors account for 60% of the variation. Certain single nucleotide polymorphisms (SNPs) are associated with density and risk of breast cancer but the association with prognosis is not clear. Purpose: To investigate associations between selected SNPs and breast cancer survival in the Malmö Diet and Cancer Study (MDCS). Material and Methods: A total of 724 unrelated women with breast cancer and registered radiological and pathological data were identified in MDCS 1991–2007, with genotyping available for 672 women. Associations among 15 SNPs, density, and breast cancer-specific survival were analyzed using logistic/Cox regression, adjusted for factors... (More)

Background: Genetic factors are important in determining breast density, and heritable factors account for 60% of the variation. Certain single nucleotide polymorphisms (SNPs) are associated with density and risk of breast cancer but the association with prognosis is not clear. Purpose: To investigate associations between selected SNPs and breast cancer survival in the Malmö Diet and Cancer Study (MDCS). Material and Methods: A total of 724 unrelated women with breast cancer and registered radiological and pathological data were identified in MDCS 1991–2007, with genotyping available for 672 women. Associations among 15 SNPs, density, and breast cancer-specific survival were analyzed using logistic/Cox regression, adjusted for factors affecting density and survival. Variants significantly associated with either density or survival were validated in a large independent breast cancer cohort (LIBRO-1). Results: Minor homozygotes of SNPs rs9383589, CCDC170 and rs6557161, ESR1 were associated with high breast density (adjusted odds ratio [AOR] 8.97, 95% confidence interval [CI] 1.35–59.57; AOR 2.08, 95% CI 1.19–3.65, respectively) and poorer breast cancer survival (adjusted hazard ratio [HRadj] 6.46, 95% CI 1.95–21.39; HRadj 2.30, 95% CI 1.33–3.96, respectively) compared to major homozygotes. For SNP rs3757318, ESR1, minor homozygotes (HRadj 7.46, 95% CI 2.28–24.45) were associated with poorer survival. We confirmed that rs6557161, ESR1 was significantly associated with both density and survival in the LIBRO-1 study. Conclusion: These findings support a shared genetic basis for density and breast cancer survival. The SNP significantly associated with both density and survival in both cohorts may be of interest in future research investigating polygenic risk scores for breast cancer risk and screening stratification purposes.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast, epidemiology, Mammography, normal variants, primary neoplasms, screening
in
Acta Radiologica
volume
61
issue
10
pages
9 pages
publisher
SAGE Publications
external identifiers
  • pmid:32036684
  • scopus:85079421622
ISSN
0284-1851
DOI
10.1177/0284185119900436
language
English
LU publication?
yes
id
01efbfef-4287-4e15-8df1-585d8dbab73c
date added to LUP
2020-03-02 16:14:02
date last changed
2024-04-03 03:56:38
@article{01efbfef-4287-4e15-8df1-585d8dbab73c,
  abstract     = {{<p>Background: Genetic factors are important in determining breast density, and heritable factors account for 60% of the variation. Certain single nucleotide polymorphisms (SNPs) are associated with density and risk of breast cancer but the association with prognosis is not clear. Purpose: To investigate associations between selected SNPs and breast cancer survival in the Malmö Diet and Cancer Study (MDCS). Material and Methods: A total of 724 unrelated women with breast cancer and registered radiological and pathological data were identified in MDCS 1991–2007, with genotyping available for 672 women. Associations among 15 SNPs, density, and breast cancer-specific survival were analyzed using logistic/Cox regression, adjusted for factors affecting density and survival. Variants significantly associated with either density or survival were validated in a large independent breast cancer cohort (LIBRO-1). Results: Minor homozygotes of SNPs rs9383589, CCDC170 and rs6557161, ESR1 were associated with high breast density (adjusted odds ratio [AOR] 8.97, 95% confidence interval [CI] 1.35–59.57; AOR 2.08, 95% CI 1.19–3.65, respectively) and poorer breast cancer survival (adjusted hazard ratio [HR<sub>adj</sub>] 6.46, 95% CI 1.95–21.39; HR<sub>adj</sub> 2.30, 95% CI 1.33–3.96, respectively) compared to major homozygotes. For SNP rs3757318, ESR1, minor homozygotes (HR<sub>adj</sub> 7.46, 95% CI 2.28–24.45) were associated with poorer survival. We confirmed that rs6557161, ESR1 was significantly associated with both density and survival in the LIBRO-1 study. Conclusion: These findings support a shared genetic basis for density and breast cancer survival. The SNP significantly associated with both density and survival in both cohorts may be of interest in future research investigating polygenic risk scores for breast cancer risk and screening stratification purposes.</p>}},
  author       = {{Sartor, Hanna and Brandt, Jasmine and Grassmann, Felix and Eriksson, Mikael and Czene, Kamila and Melander, Olle and Zackrisson, Sophia}},
  issn         = {{0284-1851}},
  keywords     = {{breast; epidemiology; Mammography; normal variants; primary neoplasms; screening}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  pages        = {{1326--1334}},
  publisher    = {{SAGE Publications}},
  series       = {{Acta Radiologica}},
  title        = {{The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival : the Malmö Diet and Cancer Study}},
  url          = {{http://dx.doi.org/10.1177/0284185119900436}},
  doi          = {{10.1177/0284185119900436}},
  volume       = {{61}},
  year         = {{2020}},
}