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Autonomic nervous symptoms in primary Sjogren's; syndrome.

Mandl, Thomas LU ; Granberg, Viktoria LU ; Apelqvist, Jan LU ; Wollmer, Per LU ; Manthorpe, Rolf LU and Jacobsson, Lennart LU (2008) In Rheumatology 47(6). p.914-919
Abstract
Objectives. Objective signs of autonomic dysfunction (AD) have been reported in patients with primary SS (pSS) while the presence of associated symptoms has not been systematically studied. Therefore, the aims of this study were (i) to assess the presence and severity of various AD symptoms in pSS patients and (ii) to relate AD symptoms to other clinical features of pSS. Methods. Thirty-eight pSS patients and 200 population-based controls were studied for presence and severity of AD symptoms using the Autonomic Symptom Profile (ASP), a validated self-completed questionnaire evaluating various AD symptoms. In addition, patients were investigated by three different objective autonomic nervous function tests. Results. pSS patients scored... (More)
Objectives. Objective signs of autonomic dysfunction (AD) have been reported in patients with primary SS (pSS) while the presence of associated symptoms has not been systematically studied. Therefore, the aims of this study were (i) to assess the presence and severity of various AD symptoms in pSS patients and (ii) to relate AD symptoms to other clinical features of pSS. Methods. Thirty-eight pSS patients and 200 population-based controls were studied for presence and severity of AD symptoms using the Autonomic Symptom Profile (ASP), a validated self-completed questionnaire evaluating various AD symptoms. In addition, patients were investigated by three different objective autonomic nervous function tests. Results. pSS patients scored significantly higher in the parasympathetic [secretomotor disorder, urinary disorder, gastroparesis (females only) and pupillomotor disorder] as well as sympathetic (orthostatic intolerance and vasomotor disorder) ASP domains compared with controls. Consequently, the standardized ASP total score was significantly increased in pSS patients [1.77 (0.57, 3.15) vs - 0.21 (-0.82, 0.72); P = 0.00] and 45% of pSS patients had an ASP total score >/=2 s.d. Furthermore, the autonomic nervous function tests showed signs of objective parasympathetic and sympathetic dysfunction as well. However, the ASP domain and total scores showed limited associations with the objective autonomic nervous function test parameters as well as clinical and serological factors of pSS. Conclusions. pSS patients showed subjective and objective signs of both a parasympathetic and a sympathetic dysfunction. However, AD symptoms showed limited associations with objective autonomic nervous function as well as other clinical features of the disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Physiology, Cardiovascular, syndrome, Nervous, Primary Sjögren's, Autonomic symptoms
in
Rheumatology
volume
47
issue
6
pages
914 - 919
publisher
Oxford University Press
external identifiers
  • wos:000256269700031
  • pmid:18411214
  • scopus:44849093834
  • pmid:18411214
ISSN
1462-0332
DOI
10.1093/rheumatology/ken107
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Diabetes Epidemiology and Neuropathy (013241560), Clinical Physiology and Nuclear Medicine Unit (013242320), Diabetes and Endocrinology (013241530), Department of Rheumatology (013036000)
id
0226fdcb-1a42-4490-ad88-fe5aaa7f0525 (old id 1147386)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18411214?dopt=Abstract
date added to LUP
2016-04-01 14:15:46
date last changed
2020-03-11 04:27:51
@article{0226fdcb-1a42-4490-ad88-fe5aaa7f0525,
  abstract     = {Objectives. Objective signs of autonomic dysfunction (AD) have been reported in patients with primary SS (pSS) while the presence of associated symptoms has not been systematically studied. Therefore, the aims of this study were (i) to assess the presence and severity of various AD symptoms in pSS patients and (ii) to relate AD symptoms to other clinical features of pSS. Methods. Thirty-eight pSS patients and 200 population-based controls were studied for presence and severity of AD symptoms using the Autonomic Symptom Profile (ASP), a validated self-completed questionnaire evaluating various AD symptoms. In addition, patients were investigated by three different objective autonomic nervous function tests. Results. pSS patients scored significantly higher in the parasympathetic [secretomotor disorder, urinary disorder, gastroparesis (females only) and pupillomotor disorder] as well as sympathetic (orthostatic intolerance and vasomotor disorder) ASP domains compared with controls. Consequently, the standardized ASP total score was significantly increased in pSS patients [1.77 (0.57, 3.15) vs - 0.21 (-0.82, 0.72); P = 0.00] and 45% of pSS patients had an ASP total score >/=2 s.d. Furthermore, the autonomic nervous function tests showed signs of objective parasympathetic and sympathetic dysfunction as well. However, the ASP domain and total scores showed limited associations with the objective autonomic nervous function test parameters as well as clinical and serological factors of pSS. Conclusions. pSS patients showed subjective and objective signs of both a parasympathetic and a sympathetic dysfunction. However, AD symptoms showed limited associations with objective autonomic nervous function as well as other clinical features of the disease.},
  author       = {Mandl, Thomas and Granberg, Viktoria and Apelqvist, Jan and Wollmer, Per and Manthorpe, Rolf and Jacobsson, Lennart},
  issn         = {1462-0332},
  language     = {eng},
  number       = {6},
  pages        = {914--919},
  publisher    = {Oxford University Press},
  series       = {Rheumatology},
  title        = {Autonomic nervous symptoms in primary Sjogren's; syndrome.},
  url          = {http://dx.doi.org/10.1093/rheumatology/ken107},
  doi          = {10.1093/rheumatology/ken107},
  volume       = {47},
  year         = {2008},
}