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Platelets promote bacterial dissemination in a mouse model of streptococcal sepsis.

Kahn, Fredrik LU ; Hurley, Sinead LU and Shannon, Oonagh LU (2013) In Microbes and Infection 15(10-11). p.669-676
Abstract
Platelets have been reported to contribute to inflammation and inflammatory disorders. In the present study, we demonstrate that platelets contribute to the acute response to bacterial infection in a mouse model of invasive Streptococcus pyogenes infection. Thrombocytopenia occurred rapidly in infected animals and this was associated with platelet activation, formation of platelet-neutrophil complexes and neutrophil activation. In order to assess the role of platelets during infection, platelets were depleted prior to infection. Platelet-depleted animals had significantly decreased platelet-neutrophil complex formation and neutrophil activation in response to infection. Importantly, significantly fewer bacteria disseminated to the blood,... (More)
Platelets have been reported to contribute to inflammation and inflammatory disorders. In the present study, we demonstrate that platelets contribute to the acute response to bacterial infection in a mouse model of invasive Streptococcus pyogenes infection. Thrombocytopenia occurred rapidly in infected animals and this was associated with platelet activation, formation of platelet-neutrophil complexes and neutrophil activation. In order to assess the role of platelets during infection, platelets were depleted prior to infection. Platelet-depleted animals had significantly decreased platelet-neutrophil complex formation and neutrophil activation in response to infection. Importantly, significantly fewer bacteria disseminated to the blood, lungs, and spleen of platelet-depleted animals. Platelet-depleted animals did not decrease as significantly in weight as the infected control animals. The results demonstrate a previously unappreciated role for platelets during the pathophysiological response to infection, whereby S. pyogenes bacteria bind to platelets and platelets facilitate bacterial dissemination. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Microbes and Infection
volume
15
issue
10-11
pages
669 - 676
publisher
Elsevier
external identifiers
  • wos:000324668100004
  • pmid:23711899
  • scopus:84884159734
ISSN
1769-714X
DOI
10.1016/j.micinf.2013.05.003
language
English
LU publication?
yes
id
0265a8e4-9d06-4a1a-98ba-8040375d36f5 (old id 3804085)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23711899?dopt=Abstract
date added to LUP
2013-06-05 14:19:10
date last changed
2019-08-04 03:06:55
@article{0265a8e4-9d06-4a1a-98ba-8040375d36f5,
  abstract     = {Platelets have been reported to contribute to inflammation and inflammatory disorders. In the present study, we demonstrate that platelets contribute to the acute response to bacterial infection in a mouse model of invasive Streptococcus pyogenes infection. Thrombocytopenia occurred rapidly in infected animals and this was associated with platelet activation, formation of platelet-neutrophil complexes and neutrophil activation. In order to assess the role of platelets during infection, platelets were depleted prior to infection. Platelet-depleted animals had significantly decreased platelet-neutrophil complex formation and neutrophil activation in response to infection. Importantly, significantly fewer bacteria disseminated to the blood, lungs, and spleen of platelet-depleted animals. Platelet-depleted animals did not decrease as significantly in weight as the infected control animals. The results demonstrate a previously unappreciated role for platelets during the pathophysiological response to infection, whereby S. pyogenes bacteria bind to platelets and platelets facilitate bacterial dissemination.},
  author       = {Kahn, Fredrik and Hurley, Sinead and Shannon, Oonagh},
  issn         = {1769-714X},
  language     = {eng},
  number       = {10-11},
  pages        = {669--676},
  publisher    = {Elsevier},
  series       = {Microbes and Infection},
  title        = {Platelets promote bacterial dissemination in a mouse model of streptococcal sepsis.},
  url          = {http://dx.doi.org/10.1016/j.micinf.2013.05.003},
  volume       = {15},
  year         = {2013},
}