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Effects of dark-chocolate on appetite variables and glucose tolerance : A 4 week randomised crossover intervention in healthy middle aged subjects

Oliveira, Diana LU and Nilsson, Anne LU (2017) In Journal of Functional Foods 37. p.390-399
Abstract

Cocoa is a well acknowledged polyphenol-rich functional product. However, the mechanisms and effects of cocoa products on glucose metabolism and appetite regulation are not clear. A crossover randomised study was carried out in twenty (4male; 16female) healthy middle-age (62.6 ± 6.5 yr) subjects with normal BMI (23.0 ± 2.0 kg/m2). Effects on postprandial glucose-, insulin- and subjective appetite responses to a preload (30 min) of 70% dark-chocolate (DC), with and without a preceding 4-week DC intervention, were evaluated. SCFA (acetate, propionate and butyrate), BDNF, GLP-1, and PYY were determined in plasma at fasting. An isocaloric white-chocolate-like product (CP) was included as a control. DC increased (main effects; p... (More)

Cocoa is a well acknowledged polyphenol-rich functional product. However, the mechanisms and effects of cocoa products on glucose metabolism and appetite regulation are not clear. A crossover randomised study was carried out in twenty (4male; 16female) healthy middle-age (62.6 ± 6.5 yr) subjects with normal BMI (23.0 ± 2.0 kg/m2). Effects on postprandial glucose-, insulin- and subjective appetite responses to a preload (30 min) of 70% dark-chocolate (DC), with and without a preceding 4-week DC intervention, were evaluated. SCFA (acetate, propionate and butyrate), BDNF, GLP-1, and PYY were determined in plasma at fasting. An isocaloric white-chocolate-like product (CP) was included as a control. DC increased (main effects; p < 0.05) glucose- and insulin responses in comparison with CP. Postprandial hunger sensations were reduced (p < 0.05), whereas acetate and propionate were higher (p < 0.05) after 4-week DC intervention. The results suggest that cocoa may play a role in appetite regulation, however the unexpected increase in postprandial glucose- and insulin concentrations requires further investigation.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Appetite-regulation, Cocoa, Colonic-fermentation, Glucose-metabolism, Gut-hormones
in
Journal of Functional Foods
volume
37
pages
10 pages
publisher
Elsevier
external identifiers
  • scopus:85029922969
  • wos:000412863400039
ISSN
1756-4646
DOI
10.1016/j.jff.2017.08.010
language
English
LU publication?
yes
id
026a0599-8019-49a0-a8f4-c455a97c5b4e
date added to LUP
2017-10-06 12:23:42
date last changed
2018-01-16 13:21:36
@article{026a0599-8019-49a0-a8f4-c455a97c5b4e,
  abstract     = {<p>Cocoa is a well acknowledged polyphenol-rich functional product. However, the mechanisms and effects of cocoa products on glucose metabolism and appetite regulation are not clear. A crossover randomised study was carried out in twenty (4male; 16female) healthy middle-age (62.6 ± 6.5 yr) subjects with normal BMI (23.0 ± 2.0 kg/m<sup>2</sup>). Effects on postprandial glucose-, insulin- and subjective appetite responses to a preload (30 min) of 70% dark-chocolate (DC), with and without a preceding 4-week DC intervention, were evaluated. SCFA (acetate, propionate and butyrate), BDNF, GLP-1, and PYY were determined in plasma at fasting. An isocaloric white-chocolate-like product (CP) was included as a control. DC increased (main effects; p &lt; 0.05) glucose- and insulin responses in comparison with CP. Postprandial hunger sensations were reduced (p &lt; 0.05), whereas acetate and propionate were higher (p &lt; 0.05) after 4-week DC intervention. The results suggest that cocoa may play a role in appetite regulation, however the unexpected increase in postprandial glucose- and insulin concentrations requires further investigation.</p>},
  author       = {Oliveira, Diana and Nilsson, Anne},
  issn         = {1756-4646},
  keyword      = {Appetite-regulation,Cocoa,Colonic-fermentation,Glucose-metabolism,Gut-hormones},
  language     = {eng},
  month        = {10},
  pages        = {390--399},
  publisher    = {Elsevier},
  series       = {Journal of Functional Foods},
  title        = {Effects of dark-chocolate on appetite variables and glucose tolerance : A 4 week randomised crossover intervention in healthy middle aged subjects},
  url          = {http://dx.doi.org/10.1016/j.jff.2017.08.010},
  volume       = {37},
  year         = {2017},
}