Mechanisms behind diffuse idiopathic peripheral neuropathy in humans–a systematic review
Tufvesson, Hanna LU
; Hamrefors, Viktor
LU
and Ohlsson, Bodil
LU
(2023)
In Scandinavian Journal of Gastroenterology
58(6).
p.572-582
- Abstract
Introduction: Diffuse peripheral neuropathy is a well-known complication of several conditions, whereas many patients have peripheral neuropathy of unknown etiology and pathophyisology. Increased knowledge of mechanisms may provide insight into enteric neuropathy with gastrointestinal dysmotility. The aim of the present systematic review was to identify mechanisms behind diffuse idiopathic peripheral neuropathies in humans. Methods: Searches were performed in PubMed, Embase, and Web of Science. Human original and review articles, written in English, describing mechanisms behind diffuse peripheral neuropathy verified by objective examinations were intended to be studied. Articles that described animal models, well-described hereditary... (More)
Introduction: Diffuse peripheral neuropathy is a well-known complication of several conditions, whereas many patients have peripheral neuropathy of unknown etiology and pathophyisology. Increased knowledge of mechanisms may provide insight into enteric neuropathy with gastrointestinal dysmotility. The aim of the present systematic review was to identify mechanisms behind diffuse idiopathic peripheral neuropathies in humans. Methods: Searches were performed in PubMed, Embase, and Web of Science. Human original and review articles, written in English, describing mechanisms behind diffuse peripheral neuropathy verified by objective examinations were intended to be studied. Articles that described animal models, well-described hereditary diseases, drug-induced neuropathy, pain syndromes, malnutrition, and local neuropathy were excluded. Results: In total, 4712 articles were identified. After scrutinizing titles and abstracts, 633 remained and were studied in full text. After the removal of articles not fulfilling inclusion or exclusion criteria, 52 were finally included in this review. The most frequently described neuropathy was diabetic neuropathy, with a wide range of mechanisms involving mitochondrial dysfunction such as oxidative stress and inflammation. Microvascular changes in diabetes and vasculitis lead to ischemia and secondary oxidative stress with inflammation. Structural changes in neurons and glial cells are observed, with abnormalities in different neurotrophic factors. Neuropathy induced by autoantibodies or immunological mechanisms is described in infectious and systemic inflammatory diseases. Several ion channels may be involved in painful neuropathy. No study identified why some patients mainly develop large fiber neuropathy and others small fiber neuropathy. Conclusion: Metabolic and immunological factors and channelopathy may be considered in diffuse idiopathic peripheral neuropathy.
(Less)
- author
- Tufvesson, Hanna
LU
; Hamrefors, Viktor
LU
and Ohlsson, Bodil
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- channelopathy, diabetic neuropathy, humans, inflammatory neuropathy, mechanisms, Peripheral neuropathy
- in
- Scandinavian Journal of Gastroenterology
- volume
- 58
- issue
- 6
- pages
- 11 pages
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:36546668
- scopus:85145041808
- ISSN
- 0036-5521
- DOI
- 10.1080/00365521.2022.2160272
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: This study was funded by the Development Foundation of Region Skåne. Maria Björklund, information specialist, Lund University Library, is acknowledged for performing the searches in the databases. Publisher Copyright: © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
- id
- 02f14034-13de-43e3-b75f-bab192518a45
- date added to LUP
- 2024-01-12 12:35:42
- date last changed
- 2024-04-13 06:03:00
@article{02f14034-13de-43e3-b75f-bab192518a45,
abstract = {{<p>Introduction: Diffuse peripheral neuropathy is a well-known complication of several conditions, whereas many patients have peripheral neuropathy of unknown etiology and pathophyisology. Increased knowledge of mechanisms may provide insight into enteric neuropathy with gastrointestinal dysmotility. The aim of the present systematic review was to identify mechanisms behind diffuse idiopathic peripheral neuropathies in humans. Methods: Searches were performed in PubMed, Embase, and Web of Science. Human original and review articles, written in English, describing mechanisms behind diffuse peripheral neuropathy verified by objective examinations were intended to be studied. Articles that described animal models, well-described hereditary diseases, drug-induced neuropathy, pain syndromes, malnutrition, and local neuropathy were excluded. Results: In total, 4712 articles were identified. After scrutinizing titles and abstracts, 633 remained and were studied in full text. After the removal of articles not fulfilling inclusion or exclusion criteria, 52 were finally included in this review. The most frequently described neuropathy was diabetic neuropathy, with a wide range of mechanisms involving mitochondrial dysfunction such as oxidative stress and inflammation. Microvascular changes in diabetes and vasculitis lead to ischemia and secondary oxidative stress with inflammation. Structural changes in neurons and glial cells are observed, with abnormalities in different neurotrophic factors. Neuropathy induced by autoantibodies or immunological mechanisms is described in infectious and systemic inflammatory diseases. Several ion channels may be involved in painful neuropathy. No study identified why some patients mainly develop large fiber neuropathy and others small fiber neuropathy. Conclusion: Metabolic and immunological factors and channelopathy may be considered in diffuse idiopathic peripheral neuropathy.</p>}},
author = {{Tufvesson, Hanna and Hamrefors, Viktor and Ohlsson, Bodil}},
issn = {{0036-5521}},
keywords = {{channelopathy; diabetic neuropathy; humans; inflammatory neuropathy; mechanisms; Peripheral neuropathy}},
language = {{eng}},
number = {{6}},
pages = {{572--582}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Gastroenterology}},
title = {{Mechanisms behind diffuse idiopathic peripheral neuropathy in humans–a systematic review}},
url = {{http://dx.doi.org/10.1080/00365521.2022.2160272}},
doi = {{10.1080/00365521.2022.2160272}},
volume = {{58}},
year = {{2023}},
}