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Sensors of Succinate : Neural Stem Cell Grafts Fight Neuroinflammation

Kokaia, Zaal LU and Lindvall, Olle LU (2018) In Cell Stem Cell 22(3). p.283-285
Abstract

In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanism reduces CNS damage and ameliorates motor impairment. In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanism reduces CNS damage and ameliorates motor impairment.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Stem Cell
volume
22
issue
3
pages
3 pages
publisher
Cell Press
external identifiers
  • scopus:85042587421
ISSN
1934-5909
DOI
10.1016/j.stem.2018.01.019
language
English
LU publication?
yes
id
031deacb-b2b7-4626-a71e-f4ccaf7cfee6
date added to LUP
2018-03-08 10:24:13
date last changed
2018-05-29 12:24:07
@article{031deacb-b2b7-4626-a71e-f4ccaf7cfee6,
  abstract     = {<p>In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanism reduces CNS damage and ameliorates motor impairment. In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanism reduces CNS damage and ameliorates motor impairment.</p>},
  author       = {Kokaia, Zaal and Lindvall, Olle},
  issn         = {1934-5909},
  language     = {eng},
  month        = {03},
  number       = {3},
  pages        = {283--285},
  publisher    = {Cell Press},
  series       = {Cell Stem Cell},
  title        = {Sensors of Succinate : Neural Stem Cell Grafts Fight Neuroinflammation},
  url          = {http://dx.doi.org/10.1016/j.stem.2018.01.019},
  volume       = {22},
  year         = {2018},
}