A bioengineering perspective on modelling the intestinal epithelial physiology in vitro
(2020) In Nature Communications 11(1).- Abstract
The small intestine is a specialised organ, essential for nutrient digestion and absorption. It is lined with a complex epithelial cell layer. Intestinal epithelial cells can be cultured in three-dimensional (3D) scaffolds as self-organising entities with distinct domains containing stem cells and differentiated cells. Recent developments in bioengineering provide new possibilities for directing the organisation of cells in vitro. In this Perspective, focusing on the small intestine, we discuss how studies at the interface between bioengineering and intestinal biology provide new insights into organ function. Specifically, we focus on engineered biomaterials, complex 3D structures resembling the intestinal architecture, and... (More)
The small intestine is a specialised organ, essential for nutrient digestion and absorption. It is lined with a complex epithelial cell layer. Intestinal epithelial cells can be cultured in three-dimensional (3D) scaffolds as self-organising entities with distinct domains containing stem cells and differentiated cells. Recent developments in bioengineering provide new possibilities for directing the organisation of cells in vitro. In this Perspective, focusing on the small intestine, we discuss how studies at the interface between bioengineering and intestinal biology provide new insights into organ function. Specifically, we focus on engineered biomaterials, complex 3D structures resembling the intestinal architecture, and micro-physiological systems.
(Less)
- author
- Antfolk, Maria LU and Jensen, Kim B.
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 11
- issue
- 1
- article number
- 6244
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85097296981
- pmid:33288759
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-020-20052-z
- language
- English
- LU publication?
- yes
- id
- 0327579e-85a9-4218-9135-483811b258c1
- date added to LUP
- 2020-12-15 07:40:16
- date last changed
- 2024-05-30 01:29:48
@article{0327579e-85a9-4218-9135-483811b258c1,
abstract = {{<p>The small intestine is a specialised organ, essential for nutrient digestion and absorption. It is lined with a complex epithelial cell layer. Intestinal epithelial cells can be cultured in three-dimensional (3D) scaffolds as self-organising entities with distinct domains containing stem cells and differentiated cells. Recent developments in bioengineering provide new possibilities for directing the organisation of cells in vitro. In this Perspective, focusing on the small intestine, we discuss how studies at the interface between bioengineering and intestinal biology provide new insights into organ function. Specifically, we focus on engineered biomaterials, complex 3D structures resembling the intestinal architecture, and micro-physiological systems.</p>}},
author = {{Antfolk, Maria and Jensen, Kim B.}},
issn = {{2041-1723}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Nature Communications}},
title = {{A bioengineering perspective on modelling the intestinal epithelial physiology in vitro}},
url = {{http://dx.doi.org/10.1038/s41467-020-20052-z}},
doi = {{10.1038/s41467-020-20052-z}},
volume = {{11}},
year = {{2020}},
}