Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases
(2020) In Cell Reports 32(12).- Abstract
Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/03762e6f-1a2a-429b-a154-43847af28bc8
- author
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- c-myc, DNA G-quadruplexes, heme, heme oxygenase-1, hemopexin, metastases, prostate cancer
- in
- Cell Reports
- volume
- 32
- issue
- 12
- article number
- 108181
- publisher
- Cell Press
- external identifiers
-
- pmid:32966797
- scopus:85091221510
- ISSN
- 2211-1247
- DOI
- 10.1016/j.celrep.2020.108181
- language
- English
- LU publication?
- yes
- id
- 03762e6f-1a2a-429b-a154-43847af28bc8
- date added to LUP
- 2020-10-26 11:40:59
- date last changed
- 2024-04-03 14:50:01
@article{03762e6f-1a2a-429b-a154-43847af28bc8, abstract = {{<p>Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.</p>}}, author = {{Canesin, Giacomo and Di Ruscio, Annalisa and Li, Mailin and Ummarino, Simone and Hedblom, Andreas and Choudhury, Reeham and Krzyzanowska, Agnieszka and Csizmadia, Eva and Palominos, Macarena and Stiehm, Anna and Ebralidze, Alexander and Chen, Shao Yong and Bassal, Mahmoud A. and Zhao, Ping and Tolosano, Emanuela and Hurley, Laurence and Bjartell, Anders and Tenen, Daniel G. and Wegiel, Barbara}}, issn = {{2211-1247}}, keywords = {{c-myc; DNA G-quadruplexes; heme; heme oxygenase-1; hemopexin; metastases; prostate cancer}}, language = {{eng}}, number = {{12}}, publisher = {{Cell Press}}, series = {{Cell Reports}}, title = {{Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases}}, url = {{http://dx.doi.org/10.1016/j.celrep.2020.108181}}, doi = {{10.1016/j.celrep.2020.108181}}, volume = {{32}}, year = {{2020}}, }