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Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Canesin, Giacomo LU ; Di Ruscio, Annalisa ; Li, Mailin ; Ummarino, Simone ; Hedblom, Andreas LU ; Choudhury, Reeham ; Krzyzanowska, Agnieszka LU ; Csizmadia, Eva ; Palominos, Macarena LU and Stiehm, Anna LU , et al. (2020) In Cell Reports 32(12).
Abstract

Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
c-myc, DNA G-quadruplexes, heme, heme oxygenase-1, hemopexin, metastases, prostate cancer
in
Cell Reports
volume
32
issue
12
article number
108181
publisher
Cell Press
external identifiers
  • pmid:32966797
  • scopus:85091221510
ISSN
2211-1247
DOI
10.1016/j.celrep.2020.108181
language
English
LU publication?
yes
id
03762e6f-1a2a-429b-a154-43847af28bc8
date added to LUP
2020-10-26 11:40:59
date last changed
2024-04-03 14:50:01
@article{03762e6f-1a2a-429b-a154-43847af28bc8,
  abstract     = {{<p>Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.</p>}},
  author       = {{Canesin, Giacomo and Di Ruscio, Annalisa and Li, Mailin and Ummarino, Simone and Hedblom, Andreas and Choudhury, Reeham and Krzyzanowska, Agnieszka and Csizmadia, Eva and Palominos, Macarena and Stiehm, Anna and Ebralidze, Alexander and Chen, Shao Yong and Bassal, Mahmoud A. and Zhao, Ping and Tolosano, Emanuela and Hurley, Laurence and Bjartell, Anders and Tenen, Daniel G. and Wegiel, Barbara}},
  issn         = {{2211-1247}},
  keywords     = {{c-myc; DNA G-quadruplexes; heme; heme oxygenase-1; hemopexin; metastases; prostate cancer}},
  language     = {{eng}},
  number       = {{12}},
  publisher    = {{Cell Press}},
  series       = {{Cell Reports}},
  title        = {{Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases}},
  url          = {{http://dx.doi.org/10.1016/j.celrep.2020.108181}},
  doi          = {{10.1016/j.celrep.2020.108181}},
  volume       = {{32}},
  year         = {{2020}},
}