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Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis

Sanden, Caroline LU ; Mori, Michiko LU ; Jogdand, Prajakta LU ; Jönsson, Jimmie ; Krishnan, Ravi ; Wang, Xiangdong and Erjefält, Jonas S. LU (2017) In Immunity, Inflammation and Disease 5(3). p.300-309
Abstract
Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory actions in vivo.
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunity, Inflammation and Disease
volume
5
issue
3
pages
300 - 309
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:28497614
  • wos:000408327600008
  • scopus:85034204636
ISSN
2050-4527
DOI
10.1002/iid3.164
language
English
LU publication?
yes
id
037e88df-b34a-46a6-bc73-e0b2de6738db
date added to LUP
2017-05-12 13:23:27
date last changed
2022-02-14 19:19:36
@article{037e88df-b34a-46a6-bc73-e0b2de6738db,
  abstract     = {{Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory actions in vivo.}},
  author       = {{Sanden, Caroline and Mori, Michiko and Jogdand, Prajakta and Jönsson, Jimmie and Krishnan, Ravi and Wang, Xiangdong and Erjefält, Jonas S.}},
  issn         = {{2050-4527}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{3}},
  pages        = {{300--309}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Immunity, Inflammation and Disease}},
  title        = {{Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis}},
  url          = {{http://dx.doi.org/10.1002/iid3.164}},
  doi          = {{10.1002/iid3.164}},
  volume       = {{5}},
  year         = {{2017}},
}