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Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis

Sanden, Caroline LU ; Mori, Michiko LU ; Jogdand, Prajakta LU ; Jönsson, Jimmie; Krishnan, Ravi; Wang, Xiangdong and Erjefält, Jonas S. LU (2017) In Immunity, Inflammation and Disease
Abstract
Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory actions in vivo.
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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Immunity, Inflammation and Disease
publisher
Wiley Online Library
ISSN
2050-4527
DOI
10.1002/iid3.164
language
English
LU publication?
yes
id
037e88df-b34a-46a6-bc73-e0b2de6738db
date added to LUP
2017-05-12 13:23:27
date last changed
2017-08-12 03:00:24
@article{037e88df-b34a-46a6-bc73-e0b2de6738db,
  abstract     = {Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory actions in vivo.},
  author       = {Sanden, Caroline and Mori, Michiko and Jogdand, Prajakta and Jönsson, Jimmie and Krishnan, Ravi and Wang, Xiangdong and Erjefält, Jonas S.},
  issn         = {2050-4527},
  language     = {eng},
  month        = {05},
  publisher    = {Wiley Online Library},
  series       = {Immunity, Inflammation and Disease},
  title        = {Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis},
  url          = {http://dx.doi.org/10.1002/iid3.164},
  year         = {2017},
}