Advanced

Mitotic activity in non-Hodgkinʹs lymphoma. Relation to the kiel classification and to prognosis

Åkerman, M. LU ; Brandt, L.; Johnson, A. LU and Olsson, H. LU (1987) In British Journal of Cancer 55(2). p.219-223
Abstract

At histopathological diagnosis of non-Hodgkin's lymphoma (NHL) the mean number of mitoses in 10 high power fields (×40) was determined in thin sections (2μm) and designated 'mitotic index' (MI). In 38 patients the thymidine labelling index (LI) of the lymphoma cells was also determined. There was a close correlation between MIs and LIs (r=0.81, P<0.001) indicating that MI reflects the proliferative activity in NHL. Among 101 patients with NHL classified according to the Kiel nomenclature MIs were generally lower in lymphomas of low grade malignant type than in the high grade malignant lymphomas. The variation of MIs within morphological subgroups was especially pronounced in high grade lymphomas. Only 18 of 49 patients (37%) with MI... (More)

At histopathological diagnosis of non-Hodgkin's lymphoma (NHL) the mean number of mitoses in 10 high power fields (×40) was determined in thin sections (2μm) and designated 'mitotic index' (MI). In 38 patients the thymidine labelling index (LI) of the lymphoma cells was also determined. There was a close correlation between MIs and LIs (r=0.81, P<0.001) indicating that MI reflects the proliferative activity in NHL. Among 101 patients with NHL classified according to the Kiel nomenclature MIs were generally lower in lymphomas of low grade malignant type than in the high grade malignant lymphomas. The variation of MIs within morphological subgroups was especially pronounced in high grade lymphomas. Only 18 of 49 patients (37%) with MI ≧ 2 have survived for 2 years in contrast to 37 of 52 patients (77%) with MI<2 (P=0.001). For patients with histologically low grade lymphomas and MI ≧ 2.0 the median survival was 23 months and for those with MI<2.0 58 months (P=0.09). Patients with high grade lymphomas and MI ≧ 2.0 had a median survival of 15 months compared to 57 months for those with MI <2.0 (P= 0.04). In a multivariate analysis of 50 patients with centroblastic-centrocytic (CB-CC) or centroblastic (CB) lymphomas the importance of different prognostic factors was analysed. Among the variables age, MI, growth pattern (follicular vs. diffuse), cell type (CB-CC vs. CB), clinical stage (I vs. II-IV), initial chemotherapy (active vs. less active) only age and MI gave significant prognostic information. It is concluded that the assessment of mitoses in NHL gives prognostic information in addition to histopathologic classification. The method is simple and the proliferative activity and histopathological diagnosis can be ascertained routinely on the same occasion.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
in
British Journal of Cancer
volume
55
issue
2
pages
219 - 223
publisher
Nature Publishing Group
external identifiers
  • scopus:0023106105
ISSN
0007-0920
DOI
10.1038/bjc.1987.41
language
English
LU publication?
yes
id
0387066e-0174-4949-bbd8-84d4d690f33a
date added to LUP
2018-12-17 16:49:55
date last changed
2019-01-06 14:20:18
@article{0387066e-0174-4949-bbd8-84d4d690f33a,
  abstract     = {<p>At histopathological diagnosis of non-Hodgkin's lymphoma (NHL) the mean number of mitoses in 10 high power fields (×40) was determined in thin sections (2μm) and designated 'mitotic index' (MI). In 38 patients the thymidine labelling index (LI) of the lymphoma cells was also determined. There was a close correlation between MIs and LIs (r=0.81, P&lt;0.001) indicating that MI reflects the proliferative activity in NHL. Among 101 patients with NHL classified according to the Kiel nomenclature MIs were generally lower in lymphomas of low grade malignant type than in the high grade malignant lymphomas. The variation of MIs within morphological subgroups was especially pronounced in high grade lymphomas. Only 18 of 49 patients (37%) with MI ≧ 2 have survived for 2 years in contrast to 37 of 52 patients (77%) with MI&lt;2 (P=0.001). For patients with histologically low grade lymphomas and MI ≧ 2.0 the median survival was 23 months and for those with MI&lt;2.0 58 months (P=0.09). Patients with high grade lymphomas and MI ≧ 2.0 had a median survival of 15 months compared to 57 months for those with MI &lt;2.0 (P= 0.04). In a multivariate analysis of 50 patients with centroblastic-centrocytic (CB-CC) or centroblastic (CB) lymphomas the importance of different prognostic factors was analysed. Among the variables age, MI, growth pattern (follicular vs. diffuse), cell type (CB-CC vs. CB), clinical stage (I vs. II-IV), initial chemotherapy (active vs. less active) only age and MI gave significant prognostic information. It is concluded that the assessment of mitoses in NHL gives prognostic information in addition to histopathologic classification. The method is simple and the proliferative activity and histopathological diagnosis can be ascertained routinely on the same occasion.</p>},
  author       = {Åkerman, M. and Brandt, L. and Johnson, A. and Olsson, H.},
  issn         = {0007-0920},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {219--223},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Mitotic activity in non-Hodgkinʹs lymphoma. Relation to the kiel classification and to prognosis},
  url          = {http://dx.doi.org/10.1038/bjc.1987.41},
  volume       = {55},
  year         = {1987},
}