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Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI

Laura Aaltonen, H. LU ; Kindvall, Simon S. LU ; Jakobsson, Jonas K. LU ; Löndahl, Jakob LU ; Olsson, Lars E. LU ; Diaz, Sandra LU ; Zackrisson, Sophia LU and Wollmer, Per LU (2018) In International Journal of Nanomedicine 13. p.2989-2995
Abstract

Background: Airspace Dimension Assessment with inhaled nanoparticles is a novel method to determine distal airway morphology. This is the first empirical study using Airspace Dimension Assessment with nanoparticles (AiDA) to estimate distal airspace radius. The technology is relatively simple and potentially accessible in clinical outpatient settings. Method: Nineteen never-smoking volunteers performed nanoparticle inhalation tests at multiple breath-hold times, and the difference in nanoparticle concentration of inhaled and exhaled gas was measured. An exponential decay curve was fitted to the concentration of recovered nanoparticles, and airspace dimensions were assessed from the half-life of the decay. Pulmonary tissue density was... (More)

Background: Airspace Dimension Assessment with inhaled nanoparticles is a novel method to determine distal airway morphology. This is the first empirical study using Airspace Dimension Assessment with nanoparticles (AiDA) to estimate distal airspace radius. The technology is relatively simple and potentially accessible in clinical outpatient settings. Method: Nineteen never-smoking volunteers performed nanoparticle inhalation tests at multiple breath-hold times, and the difference in nanoparticle concentration of inhaled and exhaled gas was measured. An exponential decay curve was fitted to the concentration of recovered nanoparticles, and airspace dimensions were assessed from the half-life of the decay. Pulmonary tissue density was measured using magnetic resonance imaging (MRI). Results: The distal airspace radius measured by AiDA correlated with lung tissue density as measured by MRI (ρ = -0.584; p = 0.0086). The linear intercept of the logarithm of the exponential decay curve correlated with forced expiratory volume in one second (FEV1) (ρ = 0.549; p = 0.0149). Conclusion: The AiDA method shows potential to be developed into a tool to assess conditions involving changes in distal airways, eg, emphysema. The intercept may reflect airway properties; this finding should be further investigated.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Airspace dimension assessment with nanoparticles, Distal airspaces, Magnetic resonance densitometry, Nanoparticles, Respiratory diagnostics
in
International Journal of Nanomedicine
volume
13
pages
7 pages
publisher
Dove Medical Press Ltd.
external identifiers
  • scopus:85047926294
ISSN
1176-9114
DOI
language
English
LU publication?
yes
id
0461ba72-d445-499e-9c3f-3336154dacd1
date added to LUP
2018-06-13 14:52:17
date last changed
2018-06-14 03:00:06
@article{0461ba72-d445-499e-9c3f-3336154dacd1,
  abstract     = {<p>Background: Airspace Dimension Assessment with inhaled nanoparticles is a novel method to determine distal airway morphology. This is the first empirical study using Airspace Dimension Assessment with nanoparticles (AiDA) to estimate distal airspace radius. The technology is relatively simple and potentially accessible in clinical outpatient settings. Method: Nineteen never-smoking volunteers performed nanoparticle inhalation tests at multiple breath-hold times, and the difference in nanoparticle concentration of inhaled and exhaled gas was measured. An exponential decay curve was fitted to the concentration of recovered nanoparticles, and airspace dimensions were assessed from the half-life of the decay. Pulmonary tissue density was measured using magnetic resonance imaging (MRI). Results: The distal airspace radius measured by AiDA correlated with lung tissue density as measured by MRI (ρ = -0.584; p = 0.0086). The linear intercept of the logarithm of the exponential decay curve correlated with forced expiratory volume in one second (FEV<sub>1</sub>) (ρ = 0.549; p = 0.0149). Conclusion: The AiDA method shows potential to be developed into a tool to assess conditions involving changes in distal airways, eg, emphysema. The intercept may reflect airway properties; this finding should be further investigated.</p>},
  author       = {Laura Aaltonen, H. and Kindvall, Simon S. and Jakobsson, Jonas K. and Löndahl, Jakob and Olsson, Lars E. and Diaz, Sandra and Zackrisson, Sophia and Wollmer, Per},
  issn         = {1176-9114},
  keyword      = {Airspace dimension assessment with nanoparticles,Distal airspaces,Magnetic resonance densitometry,Nanoparticles,Respiratory diagnostics},
  language     = {eng},
  month        = {05},
  pages        = {2989--2995},
  publisher    = {Dove Medical Press Ltd.},
  series       = {International Journal of Nanomedicine},
  title        = {Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI},
  url          = {http://dx.doi.org/},
  volume       = {13},
  year         = {2018},
}