Otitis media : Interactions between host and environment, immune and inflammatory responses
(2024) In International Journal of Pediatric Otorhinolaryngology 176.- Abstract
Objective: To review and highlight progress in otitis media (OM) research in the areas of immunology, inflammation, environmental influences and host-pathogen responses from 2019 to 2023. Opportunities for innovative future research were also identified. Data sources: PubMed database of the National Library of Medicine. Review methods: Key topics were assigned to each panel member for detailed review. Search of the literature was from June 2019 until February 2023. Draft reviews were collated, circulated, and discussed among panel members at the 22nd International Symposium on Recent Advances in Otitis Media in June 2023. The final manuscript was prepared and approved by all the panel members. Conclusions: Important advances were... (More)
Objective: To review and highlight progress in otitis media (OM) research in the areas of immunology, inflammation, environmental influences and host-pathogen responses from 2019 to 2023. Opportunities for innovative future research were also identified. Data sources: PubMed database of the National Library of Medicine. Review methods: Key topics were assigned to each panel member for detailed review. Search of the literature was from June 2019 until February 2023. Draft reviews were collated, circulated, and discussed among panel members at the 22nd International Symposium on Recent Advances in Otitis Media in June 2023. The final manuscript was prepared and approved by all the panel members. Conclusions: Important advances were identified in: environmental influences that enhance OM susceptibility; polymicrobial middle ear (ME) infections; the role of adaptive immunity defects in otitis-proneness; additional genes linked to OM; leukocyte contributions to OM pathogenesis and recovery; and novel interventions in OM based on host responses to infection. Innovative areas of research included: identification of novel bacterial genes and pathways important for OM persistence, bacterial adaptations and evolution that enhance chronicity; animal and human ME gene expression, including at the single-cell level; and Sars-CoV-2 infection of the ME and Eustachian tube.
(Less)
- author
- Nokso-Koivisto, Johanna ; Ehrlich, Garth D. ; Enoksson, Frida LU ; Komatsu, Kensei ; Mason, Kevin ; Melhus, Åsa ; Patel, Janak A. ; Vijayasekaran, Shiyan and Ryan, Allen
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bacteria, Environment, Immunology, Inflammatory, Otitis media, Virus
- in
- International Journal of Pediatric Otorhinolaryngology
- volume
- 176
- article number
- 111798
- publisher
- Elsevier
- external identifiers
-
- pmid:38041988
- scopus:85178133912
- ISSN
- 0165-5876
- DOI
- 10.1016/j.ijporl.2023.111798
- language
- English
- LU publication?
- yes
- id
- 0471ae86-9a9c-4e34-b68b-5b0d08de0a59
- date added to LUP
- 2023-12-20 15:15:11
- date last changed
- 2024-04-19 00:47:17
@article{0471ae86-9a9c-4e34-b68b-5b0d08de0a59,
abstract = {{<p>Objective: To review and highlight progress in otitis media (OM) research in the areas of immunology, inflammation, environmental influences and host-pathogen responses from 2019 to 2023. Opportunities for innovative future research were also identified. Data sources: PubMed database of the National Library of Medicine. Review methods: Key topics were assigned to each panel member for detailed review. Search of the literature was from June 2019 until February 2023. Draft reviews were collated, circulated, and discussed among panel members at the 22nd International Symposium on Recent Advances in Otitis Media in June 2023. The final manuscript was prepared and approved by all the panel members. Conclusions: Important advances were identified in: environmental influences that enhance OM susceptibility; polymicrobial middle ear (ME) infections; the role of adaptive immunity defects in otitis-proneness; additional genes linked to OM; leukocyte contributions to OM pathogenesis and recovery; and novel interventions in OM based on host responses to infection. Innovative areas of research included: identification of novel bacterial genes and pathways important for OM persistence, bacterial adaptations and evolution that enhance chronicity; animal and human ME gene expression, including at the single-cell level; and Sars-CoV-2 infection of the ME and Eustachian tube.</p>}},
author = {{Nokso-Koivisto, Johanna and Ehrlich, Garth D. and Enoksson, Frida and Komatsu, Kensei and Mason, Kevin and Melhus, Åsa and Patel, Janak A. and Vijayasekaran, Shiyan and Ryan, Allen}},
issn = {{0165-5876}},
keywords = {{Bacteria; Environment; Immunology; Inflammatory; Otitis media; Virus}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{International Journal of Pediatric Otorhinolaryngology}},
title = {{Otitis media : Interactions between host and environment, immune and inflammatory responses}},
url = {{http://dx.doi.org/10.1016/j.ijporl.2023.111798}},
doi = {{10.1016/j.ijporl.2023.111798}},
volume = {{176}},
year = {{2024}},
}