Transposable Elements : A Common Feature of Neurodevelopmental and Neurodegenerative Disorders
Jönsson, Marie E. LU ; Garza, Raquel LU
; Johansson, Pia A.
LU
and Jakobsson, Johan
LU
(2020)
In Trends in Genetics
36(8).
p.610-623
- Abstract
The etiology of most neurological disorders is poorly understood and current treatments are largely ineffective. New ideas and concepts are therefore vitally important for future research in this area. This review explores the concept that dysregulation of transposable elements (TEs) contributes to the appearance and pathology of neurodevelopmental and neurodegenerative disorders. Despite TEs making up at least half of the human genome, they are vastly understudied in relation to brain disorders. However, recent advances in sequencing technologies and gene editing approaches are now starting to unravel the pathological role of TEs. Aberrant activation of TEs has been found in many neurological disorders; the resulting pathogenic... (More)
The etiology of most neurological disorders is poorly understood and current treatments are largely ineffective. New ideas and concepts are therefore vitally important for future research in this area. This review explores the concept that dysregulation of transposable elements (TEs) contributes to the appearance and pathology of neurodevelopmental and neurodegenerative disorders. Despite TEs making up at least half of the human genome, they are vastly understudied in relation to brain disorders. However, recent advances in sequencing technologies and gene editing approaches are now starting to unravel the pathological role of TEs. Aberrant activation of TEs has been found in many neurological disorders; the resulting pathogenic effects, which include alterations of gene expression, neuroinflammation, and direct neurotoxicity, are starting to be resolved. An increased understanding of the relationship between TEs and pathological processes in the brain improves the potential for novel diagnostics and interventions for brain disorders.
(Less)
- author
- Jönsson, Marie E.
LU
; Garza, Raquel
LU
; Johansson, Pia A.
LU
and Jakobsson, Johan
LU
- organization
- publishing date
- 2020-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Genetics
- volume
- 36
- issue
- 8
- pages
- 14 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85085651321
- pmid:32499105
- ISSN
- 0168-9525
- DOI
- 10.1016/j.tig.2020.05.004
- language
- English
- LU publication?
- yes
- id
- 0481473d-7d16-41d6-b443-0daed2c7dfaf
- date added to LUP
- 2020-06-25 17:02:01
- date last changed
- 2024-04-17 10:57:12
@article{0481473d-7d16-41d6-b443-0daed2c7dfaf,
abstract = {{<p>The etiology of most neurological disorders is poorly understood and current treatments are largely ineffective. New ideas and concepts are therefore vitally important for future research in this area. This review explores the concept that dysregulation of transposable elements (TEs) contributes to the appearance and pathology of neurodevelopmental and neurodegenerative disorders. Despite TEs making up at least half of the human genome, they are vastly understudied in relation to brain disorders. However, recent advances in sequencing technologies and gene editing approaches are now starting to unravel the pathological role of TEs. Aberrant activation of TEs has been found in many neurological disorders; the resulting pathogenic effects, which include alterations of gene expression, neuroinflammation, and direct neurotoxicity, are starting to be resolved. An increased understanding of the relationship between TEs and pathological processes in the brain improves the potential for novel diagnostics and interventions for brain disorders.</p>}},
author = {{Jönsson, Marie E. and Garza, Raquel and Johansson, Pia A. and Jakobsson, Johan}},
issn = {{0168-9525}},
language = {{eng}},
month = {{08}},
number = {{8}},
pages = {{610--623}},
publisher = {{Elsevier}},
series = {{Trends in Genetics}},
title = {{Transposable Elements : A Common Feature of Neurodevelopmental and Neurodegenerative Disorders}},
url = {{http://dx.doi.org/10.1016/j.tig.2020.05.004}},
doi = {{10.1016/j.tig.2020.05.004}},
volume = {{36}},
year = {{2020}},
}