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Inflammatory markers associated with abdominal aortic aneurysm

Lindberg, Sarah; Zarrouk, Moncef LU ; Holst, Jan LU and Gottsäter, Anders LU (2016) In European Cytokine Network 27(3). p.75-80
Abstract

Purpose: Inflammation with leukocytic infiltration, degradation of extracellular matrix (ECM), and depletion of vascular smooth muscle cells (VSMC) are pathological hallmarks of abdominal aortic aneurysm (AAA). The aim of this study was to further evaluate relationships betweenAAAand inflammatory biomarkers, interleukin- 6 (IL-6), tumour necrosis factor-α (TNF-α), endothelin-1 (ET-1) and soluble urokinase-type plasminogen activator receptor (suPAR), by comparing levels in 65-year-old men with and without AAA at ultrasound screening.We also evaluated whether any biomarker can independently predict AAA at screening, and clarified potential correlations between aortic diameter and blood levels of these biomarkers. Results: There were... (More)

Purpose: Inflammation with leukocytic infiltration, degradation of extracellular matrix (ECM), and depletion of vascular smooth muscle cells (VSMC) are pathological hallmarks of abdominal aortic aneurysm (AAA). The aim of this study was to further evaluate relationships betweenAAAand inflammatory biomarkers, interleukin- 6 (IL-6), tumour necrosis factor-α (TNF-α), endothelin-1 (ET-1) and soluble urokinase-type plasminogen activator receptor (suPAR), by comparing levels in 65-year-old men with and without AAA at ultrasound screening.We also evaluated whether any biomarker can independently predict AAA at screening, and clarified potential correlations between aortic diameter and blood levels of these biomarkers. Results: There were significant (p ≤ 0.05) differences between subjects with and without AAA for the following variables: p-leukocyte count (TLC) (p<0.001), p-homocysteine (p<0.001), p-TNF-α (p = 0.023), p-IL-6 (p<0.001), p-ET-1 (p = 0.002), p-suPAR (p<0.001), ankle brachial index (ABI) (p<0.001), plasma (p)-creatinine (p = 0.049), p-total cholesterol (p<0.001), p-high density lipoprotein (HDL) (p<0.001) and low density lipoprotein (LDL) cholesterol (p = 0.001), smoking habits (p<0.001), and use of antihypertensive (p<0.001) and lipid-lowering (p = 0.001) drugs. When the above variables were stepwise excluded in a logistic regression model, only p-IL-6 (p = 0.002), p-homocysteine (p = 0.015), p-HDL (p = 0.004), ABI in the right (p = 0.005) and left (p = 0.094) leg, smoking habits (p = 0.003), and antihypertensive drug use (p = 0.045), differed between groups. Significant correlations with aortic diameter existed for p-TNF-α (p = 0.028), p-IL-6 (p<0.001), p-ET-1 (p = 0.002) and p-suPAR (p<0.001) in the entire study population, and for p-TNF-α (p = 0.023), p-ET-1 (p = 0.009) and p-suPAR (p = 0.001) among men with AAA. Conclusions: Several inflammatory biomarkers were significantly elevated and correlated with aortic diameter among 65-year old men with AAA at ultrasound screening. IL-6, homocysteine and use of antihypertensive medication remained elevated in the logistic regression model, together with known risk markers for AAA such as smoking and signs of atherosclerosis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Abdominal aortic aneurysm, Biomarkers, ET-1, IL-6, SuPAR, TNF-alpha
in
European Cytokine Network
volume
27
issue
3
pages
6 pages
publisher
John Libbey Eurotext
external identifiers
  • scopus:85006014425
  • wos:000390950900003
ISSN
1148-5493
DOI
10.1684/ecn.2016.0381
language
English
LU publication?
yes
id
048f14e3-66b7-4b0d-a8ed-a1c985364493
date added to LUP
2016-12-29 15:46:53
date last changed
2017-09-18 11:34:19
@article{048f14e3-66b7-4b0d-a8ed-a1c985364493,
  abstract     = {<p>Purpose: Inflammation with leukocytic infiltration, degradation of extracellular matrix (ECM), and depletion of vascular smooth muscle cells (VSMC) are pathological hallmarks of abdominal aortic aneurysm (AAA). The aim of this study was to further evaluate relationships betweenAAAand inflammatory biomarkers, interleukin- 6 (IL-6), tumour necrosis factor-α (TNF-α), endothelin-1 (ET-1) and soluble urokinase-type plasminogen activator receptor (suPAR), by comparing levels in 65-year-old men with and without AAA at ultrasound screening.We also evaluated whether any biomarker can independently predict AAA at screening, and clarified potential correlations between aortic diameter and blood levels of these biomarkers. Results: There were significant (p ≤ 0.05) differences between subjects with and without AAA for the following variables: p-leukocyte count (TLC) (p&lt;0.001), p-homocysteine (p&lt;0.001), p-TNF-α (p = 0.023), p-IL-6 (p&lt;0.001), p-ET-1 (p = 0.002), p-suPAR (p&lt;0.001), ankle brachial index (ABI) (p&lt;0.001), plasma (p)-creatinine (p = 0.049), p-total cholesterol (p&lt;0.001), p-high density lipoprotein (HDL) (p&lt;0.001) and low density lipoprotein (LDL) cholesterol (p = 0.001), smoking habits (p&lt;0.001), and use of antihypertensive (p&lt;0.001) and lipid-lowering (p = 0.001) drugs. When the above variables were stepwise excluded in a logistic regression model, only p-IL-6 (p = 0.002), p-homocysteine (p = 0.015), p-HDL (p = 0.004), ABI in the right (p = 0.005) and left (p = 0.094) leg, smoking habits (p = 0.003), and antihypertensive drug use (p = 0.045), differed between groups. Significant correlations with aortic diameter existed for p-TNF-α (p = 0.028), p-IL-6 (p&lt;0.001), p-ET-1 (p = 0.002) and p-suPAR (p&lt;0.001) in the entire study population, and for p-TNF-α (p = 0.023), p-ET-1 (p = 0.009) and p-suPAR (p = 0.001) among men with AAA. Conclusions: Several inflammatory biomarkers were significantly elevated and correlated with aortic diameter among 65-year old men with AAA at ultrasound screening. IL-6, homocysteine and use of antihypertensive medication remained elevated in the logistic regression model, together with known risk markers for AAA such as smoking and signs of atherosclerosis.</p>},
  author       = {Lindberg, Sarah and Zarrouk, Moncef and Holst, Jan and Gottsäter, Anders},
  issn         = {1148-5493},
  keyword      = {Abdominal aortic aneurysm,Biomarkers,ET-1,IL-6,SuPAR,TNF-alpha},
  language     = {eng},
  month        = {09},
  number       = {3},
  pages        = {75--80},
  publisher    = {John Libbey Eurotext},
  series       = {European Cytokine Network},
  title        = {Inflammatory markers associated with abdominal aortic aneurysm},
  url          = {http://dx.doi.org/10.1684/ecn.2016.0381},
  volume       = {27},
  year         = {2016},
}