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Variations in glutamine deamidation for a Châtelperronian bone assemblage as measured by peptide mass fingerprinting of collagen

Welker, Frido ; Soressi, Marie A. ; Roussel, Morgan ; van Riemsdijk, Isolde LU ; Hublin, Jean Jacques and Collins, Matthew J. LU (2017) In Science and Technology of Archaeological Research 3(1). p.15-27
Abstract

Peptide mass fingerprinting of bone collagen (ZooMS) has previously been proposed as a method to calculate the extent of the non-enzymatic degradation of glutamine into glutamic acid (deamidation). Temporal and spatial variation of glutamine deamidation at a single site, however, has not been investigated. Here we apply ZooMS screening of Châtelperronian and Early Holocene bone specimens from Quinçay, France, to explore temporal and spatial variation in glutamine deamidation. Our results indicate that chronological resolution is low, while spatial variation is high. Nevertheless, our analysis allows the identification of bone specimens that have undergone diagenetic histories remarkably different (either in length or in type) from... (More)

Peptide mass fingerprinting of bone collagen (ZooMS) has previously been proposed as a method to calculate the extent of the non-enzymatic degradation of glutamine into glutamic acid (deamidation). Temporal and spatial variation of glutamine deamidation at a single site, however, has not been investigated. Here we apply ZooMS screening of Châtelperronian and Early Holocene bone specimens from Quinçay, France, to explore temporal and spatial variation in glutamine deamidation. Our results indicate that chronological resolution is low, while spatial variation is high. Nevertheless, our analysis allows the identification of bone specimens that have undergone diagenetic histories remarkably different (either in length or in type) from spatially related bone specimens. Therefore, ZooMS ammonium-bicarbonate screening is capable of testing bone assemblage homogeneity, which could guide subsequent analysis and interpretation.

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author
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publishing date
type
Contribution to journal
publication status
published
keywords
Bone, Châtelperronian, Diagenesis, Glutamine Deamidation, Molecular biology, Quinçay, ZooMS
in
Science and Technology of Archaeological Research
volume
3
issue
1
pages
13 pages
publisher
Routledge
external identifiers
  • scopus:85015190579
ISSN
2054-8923
DOI
10.1080/20548923.2016.1258825
language
English
LU publication?
no
additional info
Publisher Copyright: © 2016, © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
id
04928457-ba3c-4253-a03f-4bbcb59c1c69
date added to LUP
2024-08-15 10:31:34
date last changed
2025-03-14 07:48:41
@article{04928457-ba3c-4253-a03f-4bbcb59c1c69,
  abstract     = {{<p>Peptide mass fingerprinting of bone collagen (ZooMS) has previously been proposed as a method to calculate the extent of the non-enzymatic degradation of glutamine into glutamic acid (deamidation). Temporal and spatial variation of glutamine deamidation at a single site, however, has not been investigated. Here we apply ZooMS screening of Châtelperronian and Early Holocene bone specimens from Quinçay, France, to explore temporal and spatial variation in glutamine deamidation. Our results indicate that chronological resolution is low, while spatial variation is high. Nevertheless, our analysis allows the identification of bone specimens that have undergone diagenetic histories remarkably different (either in length or in type) from spatially related bone specimens. Therefore, ZooMS ammonium-bicarbonate screening is capable of testing bone assemblage homogeneity, which could guide subsequent analysis and interpretation.</p>}},
  author       = {{Welker, Frido and Soressi, Marie A. and Roussel, Morgan and van Riemsdijk, Isolde and Hublin, Jean Jacques and Collins, Matthew J.}},
  issn         = {{2054-8923}},
  keywords     = {{Bone; Châtelperronian; Diagenesis; Glutamine Deamidation; Molecular biology; Quinçay; ZooMS}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{15--27}},
  publisher    = {{Routledge}},
  series       = {{Science and Technology of Archaeological Research}},
  title        = {{Variations in glutamine deamidation for a Châtelperronian bone assemblage as measured by peptide mass fingerprinting of collagen}},
  url          = {{http://dx.doi.org/10.1080/20548923.2016.1258825}},
  doi          = {{10.1080/20548923.2016.1258825}},
  volume       = {{3}},
  year         = {{2017}},
}