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A reduction of vestibulo-visual integration during transdermally administered scopolamine and dimenhydrinate. A presentation of gain control theory in motion sickness

Pyykkö, I.; Schalén, L LU ; Jäntti, V and Magnusson, Måns LU (1984) In Acta Oto-Laryngologica, Supplement 406. p.73-167
Abstract

The effect of transdermally administered scopolamine (TTS scopolamine) (release rate 5 micrograms/h) and dimenhydrinate (100 mg) was examined on optovestibular nystagmus in 16 volunteers in a randomized double-blind trial. A statistically significant decrease in the optokinetic part of nystagmus was observed during all treatments. Most profound reduction was found during treatment with two TTS scopolamine. The vestibular part was reduced by treatment with two TTS scopolamine, only. The results indicate that scopolamine and dimenhydrinate exert their effect in motion sickness by reducing the vestibular and visual influx and by partly inhibiting the integrative functioning of the vestibular nuclei. In their action, the motion sickness... (More)

The effect of transdermally administered scopolamine (TTS scopolamine) (release rate 5 micrograms/h) and dimenhydrinate (100 mg) was examined on optovestibular nystagmus in 16 volunteers in a randomized double-blind trial. A statistically significant decrease in the optokinetic part of nystagmus was observed during all treatments. Most profound reduction was found during treatment with two TTS scopolamine. The vestibular part was reduced by treatment with two TTS scopolamine, only. The results indicate that scopolamine and dimenhydrinate exert their effect in motion sickness by reducing the vestibular and visual influx and by partly inhibiting the integrative functioning of the vestibular nuclei. In their action, the motion sickness drugs seem to assist the cerebellum by diminishing impulses from various orientation reflexes in order to preserve the functional capacity of the central nervous system. Different symptoms in motion sickness seem to arise when the vestibular gain operates beyond the normal range of the cerebellar control mechanisms.

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published
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keywords
Dimenhydrinate, Female, Humans, Male, Middle Aged, Motion Sickness, Nystagmus, Physiologic, Oculomotor Nerve, Scopolamine Hydrobromide, Vestibular Nerve, Vestibular Nuclei, Vestibule, Labyrinth, Clinical Trial, Journal Article, Randomized Controlled Trial
in
Acta Oto-Laryngologica, Supplement
volume
406
pages
73 - 167
publisher
Scandinavian University Press
external identifiers
  • scopus:0021119361
ISSN
0365-5237
DOI
10.3109/00016488309123027
language
English
LU publication?
yes
id
04af7429-b3ef-4d20-b3ac-f219b2e4ab63
date added to LUP
2017-05-03 13:08:48
date last changed
2017-05-07 04:53:10
@article{04af7429-b3ef-4d20-b3ac-f219b2e4ab63,
  abstract     = {<p>The effect of transdermally administered scopolamine (TTS scopolamine) (release rate 5 micrograms/h) and dimenhydrinate (100 mg) was examined on optovestibular nystagmus in 16 volunteers in a randomized double-blind trial. A statistically significant decrease in the optokinetic part of nystagmus was observed during all treatments. Most profound reduction was found during treatment with two TTS scopolamine. The vestibular part was reduced by treatment with two TTS scopolamine, only. The results indicate that scopolamine and dimenhydrinate exert their effect in motion sickness by reducing the vestibular and visual influx and by partly inhibiting the integrative functioning of the vestibular nuclei. In their action, the motion sickness drugs seem to assist the cerebellum by diminishing impulses from various orientation reflexes in order to preserve the functional capacity of the central nervous system. Different symptoms in motion sickness seem to arise when the vestibular gain operates beyond the normal range of the cerebellar control mechanisms.</p>},
  author       = {Pyykkö, I. and Schalén, L and Jäntti, V and Magnusson, Måns},
  issn         = {0365-5237},
  keyword      = {Dimenhydrinate,Female,Humans,Male,Middle Aged,Motion Sickness,Nystagmus, Physiologic,Oculomotor Nerve,Scopolamine Hydrobromide,Vestibular Nerve,Vestibular Nuclei,Vestibule, Labyrinth,Clinical Trial,Journal Article,Randomized Controlled Trial},
  language     = {eng},
  pages        = {73--167},
  publisher    = {Scandinavian University Press},
  series       = {Acta Oto-Laryngologica, Supplement},
  title        = {A reduction of vestibulo-visual integration during transdermally administered scopolamine and dimenhydrinate. A presentation of gain control theory in motion sickness},
  url          = {http://dx.doi.org/10.3109/00016488309123027},
  volume       = {406},
  year         = {1984},
}