Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Metabolomics-based analysis in Daphnia magna after exposure to low environmental concentrations of polystyrene nanoparticles

Kelpsiene, Egle LU ; Cedervall, Tommy LU and Malmendal, Anders (2023) In Environmental Science: Nano 10(7). p.1858-1866
Abstract
Larger plastic pieces break down into micro- and eventually nano-sized plastics. This makes nanoplastics ubiquitous in the environment, giving rise to great concern for its effect on biota. Many studies use polystyrene nanoparticles (PS-NPs) as a model for nanoplastics, showing a negative impact on various organisms, but the molecular effects are yet not fully explored. Here we applied 1H nuclear magnetic resonance (NMR) metabolomics to characterize the metabolic changes in Daphnia magna during long-term (37 days) exposure to low concentrations of positively and negatively... (More)
Larger plastic pieces break down into micro- and eventually nano-sized plastics. This makes nanoplastics ubiquitous in the environment, giving rise to great concern for its effect on biota. Many studies use polystyrene nanoparticles (PS-NPs) as a model for nanoplastics, showing a negative impact on various organisms, but the molecular effects are yet not fully explored. Here we applied 1H nuclear magnetic resonance (NMR) metabolomics to characterize the metabolic changes in Daphnia magna during long-term (37 days) exposure to low concentrations of positively and negatively charged (aminated and carboxylated) PS-NPs. We show that exposure to PS-NPs at concentrations down to 3.2 μg L−1 affected amino acid metabolism and the bacterial metabolite isopropanol in D. magna. These effects were largely independent of particle concentration and surface charge. The results highlight the importance of (1) performing chronic exposures under low concentrations and (2) further investigation of particles with different surface charges. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Science: Nano
volume
10
issue
7
article number
d3en00142c
pages
9 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85161536624
ISSN
2051-8153
DOI
10.1039/D3EN00142C
language
English
LU publication?
yes
id
04e09ced-bc8a-4c65-a1aa-764cf2b159b3
date added to LUP
2023-05-31 08:56:55
date last changed
2024-01-10 08:26:31
@article{04e09ced-bc8a-4c65-a1aa-764cf2b159b3,
  abstract     = {{Larger plastic pieces break down into micro- and eventually nano-sized plastics. This makes nanoplastics ubiquitous in the environment, giving rise to great concern for its effect on biota. Many studies use polystyrene nanoparticles (PS-NPs) as a model for nanoplastics, showing a negative impact on various organisms, but the molecular effects are yet not fully explored. Here we applied 1H nuclear magnetic resonance (NMR) metabolomics to characterize the metabolic changes in <em style="color: rgba(0, 0, 0, 0.79); font-family: &quot;Source Sans Pro&quot;, source-sans-pro, museo_sans300, museo-sans, Arial, sans-serif; font-size: 16px;">Daphnia magna</em> during long-term (37 days) exposure to low concentrations of positively and negatively charged (aminated and carboxylated) PS-NPs. We show that exposure to PS-NPs at concentrations down to 3.2 μg L−1 affected amino acid metabolism and the bacterial metabolite isopropanol in <em style="color: rgba(0, 0, 0, 0.79); font-family: &quot;Source Sans Pro&quot;, source-sans-pro, museo_sans300, museo-sans, Arial, sans-serif; font-size: 16px;">D. magna</em>. These effects were largely independent of particle concentration and surface charge. The results highlight the importance of (1) performing chronic exposures under low concentrations and (2) further investigation of particles with different surface charges.}},
  author       = {{Kelpsiene, Egle and Cedervall, Tommy and Malmendal, Anders}},
  issn         = {{2051-8153}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1858--1866}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Environmental Science: Nano}},
  title        = {{Metabolomics-based analysis in <i>Daphnia magna</i>
after exposure to low environmental
concentrations of polystyrene nanoparticles}},
  url          = {{http://dx.doi.org/10.1039/D3EN00142C}},
  doi          = {{10.1039/D3EN00142C}},
  volume       = {{10}},
  year         = {{2023}},
}