Long-term follow-up of the hepatitis CHENCORE cohort: response to therapy and occurrence of liver-related complications
(2007) In Journal of Viral Hepatitis 14(8). p.556-563- Abstract
- The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver... (More)
- The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver complications during follow up, and 31% of non-responders did. Advanced age at infection and presence of the human leucocyte antigen (HLA) DRBI*1201-3 allele were possibly associated with a higher rate of progression to decompen- sated cirrhosis or HCC. Decompensated cirrhosis might be further associated with male gender, non-response to previous therapy, and lack of FILA DRBI*1301 allele, whereas HCC seems to be associated with the presence of the HLA DQ02 allele. Long-term follow up of HCV patients indicates that virological response persists over time and is associated with a very low incidence of liver complications. Advanced age at inclusion. advanced age at infection, viral genotype 1, non-response to previous therapy and possibly some specific HLA alleles are factors independently associated with a faster rate of progression towards liver complications. The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/657096
- author
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- human leucocyte antigen, carcinoma, hepatocellular, hepatitis C, follow up, cirrhosis, complications, viral clearance
- in
- Journal of Viral Hepatitis
- volume
- 14
- issue
- 8
- pages
- 556 - 563
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000248483100004
- scopus:34447545514
- ISSN
- 1365-2893
- DOI
- 10.1111/j.1365-2893.2006.00829.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000)
- id
- 05158168-7cd0-4331-a4f4-902e26021026 (old id 657096)
- date added to LUP
- 2016-04-01 12:20:26
- date last changed
- 2022-01-27 02:12:58
@article{05158168-7cd0-4331-a4f4-902e26021026,
abstract = {{The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver complications during follow up, and 31% of non-responders did. Advanced age at infection and presence of the human leucocyte antigen (HLA) DRBI*1201-3 allele were possibly associated with a higher rate of progression to decompen- sated cirrhosis or HCC. Decompensated cirrhosis might be further associated with male gender, non-response to previous therapy, and lack of FILA DRBI*1301 allele, whereas HCC seems to be associated with the presence of the HLA DQ02 allele. Long-term follow up of HCV patients indicates that virological response persists over time and is associated with a very low incidence of liver complications. Advanced age at inclusion. advanced age at infection, viral genotype 1, non-response to previous therapy and possibly some specific HLA alleles are factors independently associated with a faster rate of progression towards liver complications. The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients.}},
author = {{Pradat, P. and Tillmann, H. L. and Sauleda, S. and Braconier, Jean Henrik and Saracco, G. and Thursz, M. and Goldin, R. and Winkler, R. and Alberti, A. and Esteban, J.-I. and Hadziyannis, S. and Rizzetto, M. and Thomas, H. and Manns, M. P. and Trepo, C.}},
issn = {{1365-2893}},
keywords = {{human leucocyte antigen; carcinoma; hepatocellular; hepatitis C; follow up; cirrhosis; complications; viral clearance}},
language = {{eng}},
number = {{8}},
pages = {{556--563}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Viral Hepatitis}},
title = {{Long-term follow-up of the hepatitis CHENCORE cohort: response to therapy and occurrence of liver-related complications}},
url = {{http://dx.doi.org/10.1111/j.1365-2893.2006.00829.x}},
doi = {{10.1111/j.1365-2893.2006.00829.x}},
volume = {{14}},
year = {{2007}},
}