Short-term ambient particle radioactivity level and renal function in older men: Insight from the Normative Aging Study
Gao, Xu ; Koutrakis, Petros ; Blomberg, Annelise J LU
; Coull, Brent
; Vokonas, Pantel
; Schwartz, Joel
and Baccarelli, Andrea A
(2019)
In Environment International
131.
p.105018-105018
- Abstract
BACKGROUND: Whole-body and thoracic ionizing radiation exposure are both associated with the development of renal dysfunction. However, whether low-level environmental radiation from air pollution affects renal function remains unknown.
OBJECTIVES: We investigated the association of particle radioactivity (PR) with renal function defined by the estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) in the Normative Aging Study.
METHODS: This longitudinal analysis included 2491 medical visits from 809 white males enrolled between 1999 and 2013. The eGFR was calculated using the CKD-EPI and MDRD equations, and CKD cases were identified as those with an eGFR <60 mL/min/1.73 m2. Gross β activity measured... (More)
BACKGROUND: Whole-body and thoracic ionizing radiation exposure are both associated with the development of renal dysfunction. However, whether low-level environmental radiation from air pollution affects renal function remains unknown.
OBJECTIVES: We investigated the association of particle radioactivity (PR) with renal function defined by the estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) in the Normative Aging Study.
METHODS: This longitudinal analysis included 2491 medical visits from 809 white males enrolled between 1999 and 2013. The eGFR was calculated using the CKD-EPI and MDRD equations, and CKD cases were identified as those with an eGFR <60 mL/min/1.73 m2. Gross β activity measured by five monitors of the U.S. Environmental Protection Agency's RadNet monitoring network was utilized to represent PR.
RESULTS: Ambient PR levels from 1 to 28 days prior to clinical visit demonstrated robust negative associations with both forms of eGFR, but not with the increased odds of CKD. An interquartile range higher 28-day average ambient PR level was significantly associated with 0.83-mL/min/1.73 m2 lower eGFR estimated by the CKD-EPI equation (95% confidence interval: -1.46, -0.20, p-value = 0.01). Controlling for PM2.5 or black carbon in the model slightly attenuated the PR effects on eGFR. However, in individuals with the highest levels (3rd tertile) of C-reactive protein (CRP) or fibrinogen, we observed robust associations of PR with eGFR and CKD, suggesting that systemic inflammation may modify the PR-eGFR and PR-CKD relationships.
CONCLUSIONS: Our study reveals adverse health effects of short-term low-level ambient PR on the renal function, providing evidence to guide further study of the interplay between PR, inflammation, and renal health.
(Less)
- author
- Gao, Xu
; Koutrakis, Petros
; Blomberg, Annelise J
LU
; Coull, Brent
; Vokonas, Pantel
; Schwartz, Joel
and Baccarelli, Andrea A
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Glomerular Filtration Rate, Humans, Male, Radioactivity
- in
- Environment International
- volume
- 131
- pages
- 105018 - 105018
- publisher
- Elsevier
- external identifiers
-
- pmid:31336254
- scopus:85069596729
- ISSN
- 1873-6750
- DOI
- 10.1016/j.envint.2019.105018
- language
- English
- LU publication?
- no
- id
- 053fd737-5604-4c11-a8a5-3eb1a6ac8fe7
- date added to LUP
- 2021-09-09 11:51:39
- date last changed
- 2024-11-18 08:31:08
@article{053fd737-5604-4c11-a8a5-3eb1a6ac8fe7,
abstract = {{<p>BACKGROUND: Whole-body and thoracic ionizing radiation exposure are both associated with the development of renal dysfunction. However, whether low-level environmental radiation from air pollution affects renal function remains unknown.</p><p>OBJECTIVES: We investigated the association of particle radioactivity (PR) with renal function defined by the estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD) in the Normative Aging Study.</p><p>METHODS: This longitudinal analysis included 2491 medical visits from 809 white males enrolled between 1999 and 2013. The eGFR was calculated using the CKD-EPI and MDRD equations, and CKD cases were identified as those with an eGFR <60 mL/min/1.73 m2. Gross β activity measured by five monitors of the U.S. Environmental Protection Agency's RadNet monitoring network was utilized to represent PR.</p><p>RESULTS: Ambient PR levels from 1 to 28 days prior to clinical visit demonstrated robust negative associations with both forms of eGFR, but not with the increased odds of CKD. An interquartile range higher 28-day average ambient PR level was significantly associated with 0.83-mL/min/1.73 m2 lower eGFR estimated by the CKD-EPI equation (95% confidence interval: -1.46, -0.20, p-value = 0.01). Controlling for PM2.5 or black carbon in the model slightly attenuated the PR effects on eGFR. However, in individuals with the highest levels (3rd tertile) of C-reactive protein (CRP) or fibrinogen, we observed robust associations of PR with eGFR and CKD, suggesting that systemic inflammation may modify the PR-eGFR and PR-CKD relationships.</p><p>CONCLUSIONS: Our study reveals adverse health effects of short-term low-level ambient PR on the renal function, providing evidence to guide further study of the interplay between PR, inflammation, and renal health.</p>}},
author = {{Gao, Xu and Koutrakis, Petros and Blomberg, Annelise J and Coull, Brent and Vokonas, Pantel and Schwartz, Joel and Baccarelli, Andrea A}},
issn = {{1873-6750}},
keywords = {{Aged; Glomerular Filtration Rate; Humans; Male; Radioactivity}},
language = {{eng}},
pages = {{105018--105018}},
publisher = {{Elsevier}},
series = {{Environment International}},
title = {{Short-term ambient particle radioactivity level and renal function in older men: Insight from the Normative Aging Study}},
url = {{http://dx.doi.org/10.1016/j.envint.2019.105018}},
doi = {{10.1016/j.envint.2019.105018}},
volume = {{131}},
year = {{2019}},
}