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Risk-tailored starting age of breast cancer screening based on women's reproductive profile : A nationwide cohort study

Mukama, Trasias LU ; Fallah, Mahdi LU ; Tian, Yu ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Brenner, Hermann LU and Kharazmi, Elham LU (2020) In European Journal of Cancer 124. p.207-213
Abstract

Background: Although reproductive history is recognised to affect the risk of breast cancer, current breast cancer screening guidelines do not consider risk differences by this important factor. As there is a need for an earlier screening in women at increased risk of breast cancer, we provided evidence-based risk-adapted starting age of screening based on different reproductive profiles. 

Material and methods: We conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931. Records of study participants in Swedish Cancer Registry, Multi-generation Register, Cause of Death Register, and national censuses (follow-up, 1958–2015) have been linked. We used 10-year cumulative risk of breast cancer curves to... (More)

Background: Although reproductive history is recognised to affect the risk of breast cancer, current breast cancer screening guidelines do not consider risk differences by this important factor. As there is a need for an earlier screening in women at increased risk of breast cancer, we provided evidence-based risk-adapted starting age of screening based on different reproductive profiles. 

Material and methods: We conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931. Records of study participants in Swedish Cancer Registry, Multi-generation Register, Cause of Death Register, and national censuses (follow-up, 1958–2015) have been linked. We used 10-year cumulative risk of breast cancer curves to determine the age at which women with different reproductive factors attained the risk level at which breast screening is usually recommended. 

Results: The 10-year cumulative risk of breast cancer at age 40, 45 and 50 years in the general population, at which current screening guidelines recommend screening was calculated. We found that women with various reproductive factors (defined by parity and age at first birth) obtained this level of risk at different ages. The difference was between nine years later and three years earlier. 

Conclusions: This study provides the age at which women with particular reproductive profile could start risk-adapted breast cancer screening. This supplies novel information for clinicians and women about when to start breast cancer screening and is an important step towards a personalised screening.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Age at first birth, Breast cancer, Parity, Reproductive factors, Risk-adapted screening, Screening, Sporadic breast cancer
in
European Journal of Cancer
volume
124
pages
207 - 213
publisher
IFAC & Elsevier Ltd.
external identifiers
  • pmid:31761537
  • scopus:85075816160
ISSN
0959-8049
DOI
10.1016/j.ejca.2019.10.011
language
English
LU publication?
yes
id
05415921-308c-4b94-aee3-0028e24e22e3
date added to LUP
2019-12-16 13:17:52
date last changed
2020-01-13 02:36:32
@article{05415921-308c-4b94-aee3-0028e24e22e3,
  abstract     = {<p>Background: Although reproductive history is recognised to affect the risk of breast cancer, current breast cancer screening guidelines do not consider risk differences by this important factor. As there is a need for an earlier screening in women at increased risk of breast cancer, we provided evidence-based risk-adapted starting age of screening based on different reproductive profiles. </p><p>Material and methods: We conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931. Records of study participants in Swedish Cancer Registry, Multi-generation Register, Cause of Death Register, and national censuses (follow-up, 1958–2015) have been linked. We used 10-year cumulative risk of breast cancer curves to determine the age at which women with different reproductive factors attained the risk level at which breast screening is usually recommended. </p><p>Results: The 10-year cumulative risk of breast cancer at age 40, 45 and 50 years in the general population, at which current screening guidelines recommend screening was calculated. We found that women with various reproductive factors (defined by parity and age at first birth) obtained this level of risk at different ages. The difference was between nine years later and three years earlier. </p><p>Conclusions: This study provides the age at which women with particular reproductive profile could start risk-adapted breast cancer screening. This supplies novel information for clinicians and women about when to start breast cancer screening and is an important step towards a personalised screening.</p>},
  author       = {Mukama, Trasias and Fallah, Mahdi and Tian, Yu and Sundquist, Kristina and Sundquist, Jan and Brenner, Hermann and Kharazmi, Elham},
  issn         = {0959-8049},
  language     = {eng},
  pages        = {207--213},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Risk-tailored starting age of breast cancer screening based on women's reproductive profile : A nationwide cohort study},
  url          = {http://dx.doi.org/10.1016/j.ejca.2019.10.011},
  doi          = {10.1016/j.ejca.2019.10.011},
  volume       = {124},
  year         = {2020},
}