Quantification of insulin secretion in relation to insulin sensitivity in nondiabetic postmenopausal women.
(2002) In Diabetes 51(Suppl 1). p.202-211- Abstract
- To evaluate mechanisms underlying the close association between insulin secretion and insulin sensitivity, insulin sensitivity was evaluated by the euglycemic-hyperinsulinemic clamp technique (M/I(clamp)) and insulin secretion was determined from the 75-g oral glucose tolerance test (OGTT) and from the glucose-dependent arginine-stimulation test in 81 nondiabetic postmenopausal women, all aged 61 years. M/I(clamp) was normally distributed with mean plus minus SD of 69.9 plus minus 30.5 nmol glucose center dot kg(-1) center dot min(-1)/pmol insulin center dot l(-1). It was found that the several different measures of insulin secretion from the OGTT and the glucose-dependent arginine-stimulation test were all inversely related to M/I(clamp).... (More)
- To evaluate mechanisms underlying the close association between insulin secretion and insulin sensitivity, insulin sensitivity was evaluated by the euglycemic-hyperinsulinemic clamp technique (M/I(clamp)) and insulin secretion was determined from the 75-g oral glucose tolerance test (OGTT) and from the glucose-dependent arginine-stimulation test in 81 nondiabetic postmenopausal women, all aged 61 years. M/I(clamp) was normally distributed with mean plus minus SD of 69.9 plus minus 30.5 nmol glucose center dot kg(-1) center dot min(-1)/pmol insulin center dot l(-1). It was found that the several different measures of insulin secretion from the OGTT and the glucose-dependent arginine-stimulation test were all inversely related to M/I(clamp). However, measures determining the direct insulin responses were more markedly potentiated by low M/I(clamp) than were measures determining glucose potentiation of insulin secretion. Moreover, the product of M/I(clamp) times measures of insulin secretion (disposition index [DI]) was inversely related to the 2-h glucose value. Finally, surrogate insulin sensitivity measures quantified from OGTT and the glucose-dependent arginine-stimulation test only weakly correlated to M/I(clamp) (R(2) approximate 0.25). Thus, 1) insulin secretion is adaptively increased when insulin sensitivity is low in nondiabetic postmenopausal women; 2) beta-cell exocytotic ability shows more efficient adaptation than beta-cell glucose recognition to low insulin sensitivity; 3) impaired beta-cell adaptation (i.e., low DI) is associated with higher 2-h glucose values during OGTT, although other regulatory mechanisms also exist; and 4) indirect surrogate measures of insulin sensitivity only weakly correlate to insulin sensitivity as determined by the euglycemic-hyperinsulinemic clamp. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/106364
- author
- Ahrén, Bo LU and Larsson, Hillevi
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 51
- issue
- Suppl 1
- pages
- 202 - 211
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- wos:000173599900033
- scopus:0036314331
- ISSN
- 1939-327X
- DOI
- 10.2337/diabetes.51.2007.S202
- language
- English
- LU publication?
- yes
- id
- 05682002-4c5d-4990-a856-49d868c9f363 (old id 106364)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11815481&dopt=Abstract
- date added to LUP
- 2016-04-01 16:07:29
- date last changed
- 2024-01-11 01:59:24
@article{05682002-4c5d-4990-a856-49d868c9f363,
abstract = {{To evaluate mechanisms underlying the close association between insulin secretion and insulin sensitivity, insulin sensitivity was evaluated by the euglycemic-hyperinsulinemic clamp technique (M/I(clamp)) and insulin secretion was determined from the 75-g oral glucose tolerance test (OGTT) and from the glucose-dependent arginine-stimulation test in 81 nondiabetic postmenopausal women, all aged 61 years. M/I(clamp) was normally distributed with mean plus minus SD of 69.9 plus minus 30.5 nmol glucose center dot kg(-1) center dot min(-1)/pmol insulin center dot l(-1). It was found that the several different measures of insulin secretion from the OGTT and the glucose-dependent arginine-stimulation test were all inversely related to M/I(clamp). However, measures determining the direct insulin responses were more markedly potentiated by low M/I(clamp) than were measures determining glucose potentiation of insulin secretion. Moreover, the product of M/I(clamp) times measures of insulin secretion (disposition index [DI]) was inversely related to the 2-h glucose value. Finally, surrogate insulin sensitivity measures quantified from OGTT and the glucose-dependent arginine-stimulation test only weakly correlated to M/I(clamp) (R(2) approximate 0.25). Thus, 1) insulin secretion is adaptively increased when insulin sensitivity is low in nondiabetic postmenopausal women; 2) beta-cell exocytotic ability shows more efficient adaptation than beta-cell glucose recognition to low insulin sensitivity; 3) impaired beta-cell adaptation (i.e., low DI) is associated with higher 2-h glucose values during OGTT, although other regulatory mechanisms also exist; and 4) indirect surrogate measures of insulin sensitivity only weakly correlate to insulin sensitivity as determined by the euglycemic-hyperinsulinemic clamp.}},
author = {{Ahrén, Bo and Larsson, Hillevi}},
issn = {{1939-327X}},
language = {{eng}},
number = {{Suppl 1}},
pages = {{202--211}},
publisher = {{American Diabetes Association Inc.}},
series = {{Diabetes}},
title = {{Quantification of insulin secretion in relation to insulin sensitivity in nondiabetic postmenopausal women.}},
url = {{http://dx.doi.org/10.2337/diabetes.51.2007.S202}},
doi = {{10.2337/diabetes.51.2007.S202}},
volume = {{51}},
year = {{2002}},
}