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Identification of Inflammatory and Disease-Associated Plasma Proteins that Associate with Intake of Added Sugar and Sugar-Sweetened Beverages and Their Role in Type 2 Diabetes Risk

Ramne, Stina LU orcid ; Drake, Isabel LU ; Ericson, Ulrika LU ; Nilsson, Jan LU ; Orho-Melander, Marju LU ; Engström, Gunnar LU and Sonestedt, Emily LU orcid (2020) In Nutrients 12(10).
Abstract

It has been suggested that high intake of added sugar and sugar-sweetened beverages (SSBs) increase the level of circulating inflammatory proteins and that chronic inflammation plays a role in type 2 diabetes (T2D) development. We aim to examine how added sugar and SSB intake associate with 136 measured plasma proteins and C-reactive protein (CRP) in the Malmö Diet and Cancer-Cardiovascular Cohort (n = 4382), and examine if the identified added sugar- and SSB-associated proteins associate with T2D incidence. A two-step iterative resampling approach was used to internally replicate proteins that associated with added sugar and SSB intake. Nine proteins were identified to associate with added sugar intake, of which only two associated... (More)

It has been suggested that high intake of added sugar and sugar-sweetened beverages (SSBs) increase the level of circulating inflammatory proteins and that chronic inflammation plays a role in type 2 diabetes (T2D) development. We aim to examine how added sugar and SSB intake associate with 136 measured plasma proteins and C-reactive protein (CRP) in the Malmö Diet and Cancer-Cardiovascular Cohort (n = 4382), and examine if the identified added sugar- and SSB-associated proteins associate with T2D incidence. A two-step iterative resampling approach was used to internally replicate proteins that associated with added sugar and SSB intake. Nine proteins were identified to associate with added sugar intake, of which only two associated with T2D incidence (p < 0.00045). Seven proteins were identified to associate with SSB intake, of which six associated strongly with T2D incidence (p < 6.9 × 10-8). No significant associations were observed between added sugar and SSB intake and CRP concentrations. In summary, our elucidation of the relationship between plasma proteome and added sugar and SSB intake, in relation to future T2D risk, demonstrated that SSB intake, rather than the total intake of added sugar, was related to a T2D-pathological proteomic signature. However, external replication is needed to verify the findings.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrients
volume
12
issue
10
article number
3129
publisher
MDPI AG
external identifiers
  • scopus:85092892300
  • pmid:33066363
ISSN
2072-6643
DOI
10.3390/nu12103129
project
Sugar consumption and cardiometabolic risk
language
English
LU publication?
yes
id
0606d664-4652-4f23-9700-ddad5bbc54ee
date added to LUP
2020-10-26 09:02:27
date last changed
2024-04-03 15:17:09
@article{0606d664-4652-4f23-9700-ddad5bbc54ee,
  abstract     = {{<p>It has been suggested that high intake of added sugar and sugar-sweetened beverages (SSBs) increase the level of circulating inflammatory proteins and that chronic inflammation plays a role in type 2 diabetes (T2D) development. We aim to examine how added sugar and SSB intake associate with 136 measured plasma proteins and C-reactive protein (CRP) in the Malmö Diet and Cancer-Cardiovascular Cohort (n = 4382), and examine if the identified added sugar- and SSB-associated proteins associate with T2D incidence. A two-step iterative resampling approach was used to internally replicate proteins that associated with added sugar and SSB intake. Nine proteins were identified to associate with added sugar intake, of which only two associated with T2D incidence (p &lt; 0.00045). Seven proteins were identified to associate with SSB intake, of which six associated strongly with T2D incidence (p &lt; 6.9 × 10-8). No significant associations were observed between added sugar and SSB intake and CRP concentrations. In summary, our elucidation of the relationship between plasma proteome and added sugar and SSB intake, in relation to future T2D risk, demonstrated that SSB intake, rather than the total intake of added sugar, was related to a T2D-pathological proteomic signature. However, external replication is needed to verify the findings.</p>}},
  author       = {{Ramne, Stina and Drake, Isabel and Ericson, Ulrika and Nilsson, Jan and Orho-Melander, Marju and Engström, Gunnar and Sonestedt, Emily}},
  issn         = {{2072-6643}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Identification of Inflammatory and Disease-Associated Plasma Proteins that Associate with Intake of Added Sugar and Sugar-Sweetened Beverages and Their Role in Type 2 Diabetes Risk}},
  url          = {{http://dx.doi.org/10.3390/nu12103129}},
  doi          = {{10.3390/nu12103129}},
  volume       = {{12}},
  year         = {{2020}},
}