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X-rays can trigger the FLASH effect : Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

Montay-Gruel, Pierre ; Bouchet, Audrey ; Jaccard, Maud ; Patin, David ; Serduc, Raphael ; Aim, Warren ; Petersson, Kristoffer LU ; Petit, Benoit ; Bailat, Claude and Bourhis, Jean , et al. (2018) In Radiotherapy and Oncology 129(3). p.582-588
Abstract

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.

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publishing date
type
Contribution to journal
publication status
published
keywords
Cognitive impairment, Radiation-induced brain injury, Synchrotron radiation, Ultra-high dose-rate X-ray radiation
in
Radiotherapy and Oncology
volume
129
issue
3
pages
582 - 588
publisher
Elsevier
external identifiers
  • pmid:30177374
  • scopus:85052736289
ISSN
0167-8140
DOI
10.1016/j.radonc.2018.08.016
language
English
LU publication?
no
additional info
Publisher Copyright: © 2018
id
0629637e-1602-4e73-92c9-5ac0a57673f6
date added to LUP
2021-11-03 18:16:34
date last changed
2024-04-20 15:53:09
@article{0629637e-1602-4e73-92c9-5ac0a57673f6,
  abstract     = {{<p>This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.</p>}},
  author       = {{Montay-Gruel, Pierre and Bouchet, Audrey and Jaccard, Maud and Patin, David and Serduc, Raphael and Aim, Warren and Petersson, Kristoffer and Petit, Benoit and Bailat, Claude and Bourhis, Jean and Bräuer-Krisch, Elke and Vozenin, Marie Catherine}},
  issn         = {{0167-8140}},
  keywords     = {{Cognitive impairment; Radiation-induced brain injury; Synchrotron radiation; Ultra-high dose-rate X-ray radiation}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{582--588}},
  publisher    = {{Elsevier}},
  series       = {{Radiotherapy and Oncology}},
  title        = {{X-rays can trigger the FLASH effect : Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice}},
  url          = {{http://dx.doi.org/10.1016/j.radonc.2018.08.016}},
  doi          = {{10.1016/j.radonc.2018.08.016}},
  volume       = {{129}},
  year         = {{2018}},
}