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Psychiatric disorders in offspring of childhood or adolescent central nervous system tumor survivors : a national cohort study

Huang, Wuqing LU orcid ; Sundquist, Kristina LU ; Sundquist, Jan LU and Ji, Jianguang LU orcid (2021) In Cancer Medicine 10(2). p.675-683
Abstract

BACKGROUND: Children experience a higher risk of psychiatric problems when their parents are diagnosed with cancer. However, the psychological effect among offspring who are born after parental cancer diagnosed in childhood or adolescence is unknown. We aimed to investigate the risk of psychiatric disorders in children of survivors with childhood or adolescent central nervous system (CNS) tumors.

METHODS: By combining several nationwide Swedish registers, we identified all children who had at least one parent previously diagnosed with CNS tumor below the age of 20. Five children without parental CNS tumor were randomly selected for the matching. Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95%... (More)

BACKGROUND: Children experience a higher risk of psychiatric problems when their parents are diagnosed with cancer. However, the psychological effect among offspring who are born after parental cancer diagnosed in childhood or adolescence is unknown. We aimed to investigate the risk of psychiatric disorders in children of survivors with childhood or adolescent central nervous system (CNS) tumors.

METHODS: By combining several nationwide Swedish registers, we identified all children who had at least one parent previously diagnosed with CNS tumor below the age of 20. Five children without parental CNS tumor were randomly selected for the matching. Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95% confidence interval (CI).

RESULTS: The incidence rate of psychiatric disorders was 8.46 per 1000 person-years in children of CNS tumor survivors, whereas the rate was 7.47 in the matched comparisons, yielding an adjusted HR of 1.10 (95% CI = 0.94, 1.28). Boys of survivors had a higher risk of psychiatric disorders (adjusted HR = 1.29, 95% CI = 1.04, 1.59). The risk of the specific types of psychiatric disorders in children of tumor survivors was comparable with that in the matched comparisons, except for mental retardation. Children of survivors experienced 2.36 times higher risk of mental retardation (95% CI = 1.21, 4.58), mainly of mild mental retardation (adjusted HR = 2.99, 95% CI = 1.40, 6.38).

CONCLUSION: Children of survivors with CNS tumor in early life did not experience a significantly increased risk of overall psychiatric disorders, with the exception of an elevated risk of mental retardation that was mainly mild.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Medicine
volume
10
issue
2
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85094664696
  • pmid:33135321
ISSN
2045-7634
DOI
10.1002/cam4.3591
project
Health status and academic performance in offspring of central nervous system tumor survivors
language
English
LU publication?
yes
additional info
© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
id
06425562-7663-4050-b684-c2032a594bb6
date added to LUP
2020-11-12 09:20:56
date last changed
2024-03-20 19:39:25
@article{06425562-7663-4050-b684-c2032a594bb6,
  abstract     = {{<p>BACKGROUND: Children experience a higher risk of psychiatric problems when their parents are diagnosed with cancer. However, the psychological effect among offspring who are born after parental cancer diagnosed in childhood or adolescence is unknown. We aimed to investigate the risk of psychiatric disorders in children of survivors with childhood or adolescent central nervous system (CNS) tumors.</p><p>METHODS: By combining several nationwide Swedish registers, we identified all children who had at least one parent previously diagnosed with CNS tumor below the age of 20. Five children without parental CNS tumor were randomly selected for the matching. Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95% confidence interval (CI).</p><p>RESULTS: The incidence rate of psychiatric disorders was 8.46 per 1000 person-years in children of CNS tumor survivors, whereas the rate was 7.47 in the matched comparisons, yielding an adjusted HR of 1.10 (95% CI = 0.94, 1.28). Boys of survivors had a higher risk of psychiatric disorders (adjusted HR = 1.29, 95% CI = 1.04, 1.59). The risk of the specific types of psychiatric disorders in children of tumor survivors was comparable with that in the matched comparisons, except for mental retardation. Children of survivors experienced 2.36 times higher risk of mental retardation (95% CI = 1.21, 4.58), mainly of mild mental retardation (adjusted HR = 2.99, 95% CI = 1.40, 6.38).</p><p>CONCLUSION: Children of survivors with CNS tumor in early life did not experience a significantly increased risk of overall psychiatric disorders, with the exception of an elevated risk of mental retardation that was mainly mild.</p>}},
  author       = {{Huang, Wuqing and Sundquist, Kristina and Sundquist, Jan and Ji, Jianguang}},
  issn         = {{2045-7634}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{675--683}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Cancer Medicine}},
  title        = {{Psychiatric disorders in offspring of childhood or adolescent central nervous system tumor survivors : a national cohort study}},
  url          = {{http://dx.doi.org/10.1002/cam4.3591}},
  doi          = {{10.1002/cam4.3591}},
  volume       = {{10}},
  year         = {{2021}},
}