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A novel method for creatinine adjustment makes the revised Lund–Malmö GFR estimating equation applicable in children

Björk, Jonas LU ; Nyman, Ulf LU ; Delanaye, Pierre ; Grubb, Anders LU orcid ; Larsson, Anders ; Vranken, Laura ; Åkesson, Anna LU and Pottel, Hans (2020) In Scandinavian Journal of Clinical and Laboratory Investigation 80(6). p.456-463
Abstract

The aim of this study was to establish creatinine growth curves separately for males and females that can be used to adjust childhood levels of serum creatinine to corresponding adult levels. Linear regression with fractional polynomials of age as independent variable was used to construct creatinine growth curves for a reference cohort (n = 83,157 samples from Belgium and Sweden, age 2–40 years). Adjusted creatinine obtained from the growth curves was used to improve accuracy of estimated glomerular filtration rate (eGFR) based on the Lund–Malmö revised (LMR) equation in children. The LMR equation based on creatinine values adjusted to age 18 years was validated against measured GFR (mGFR) in a separate cohort of 4005 children from... (More)

The aim of this study was to establish creatinine growth curves separately for males and females that can be used to adjust childhood levels of serum creatinine to corresponding adult levels. Linear regression with fractional polynomials of age as independent variable was used to construct creatinine growth curves for a reference cohort (n = 83,157 samples from Belgium and Sweden, age 2–40 years). Adjusted creatinine obtained from the growth curves was used to improve accuracy of estimated glomerular filtration rate (eGFR) based on the Lund–Malmö revised (LMR) equation in children. The LMR equation based on creatinine values adjusted to age 18 years was validated against measured GFR (mGFR) in a separate cohort of 4005 children from four different European countries. Validation metrics included median bias, precision, and accuracy expressed as percentage of estimates within ±30% (P30) of mGFR. Remarkable improvements in bias and accuracy were observed; P30 increased from 56% to 74% after creatinine adjustments in children with mGFR <75 mL/min/1.73 m2 (n = 932), while P30 was relatively unchanged (89–90%) at mGFR ≥75 mL/min/1.73 m2(n = 3073). The suggested approach with adjusted creatinine makes LMR applicable in children irrespective of their renal function.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chronic kidney disease, Creatinine, glomerular filtration rate, kidney function tests, renal failure
in
Scandinavian Journal of Clinical and Laboratory Investigation
volume
80
issue
6
pages
8 pages
publisher
Informa Healthcare
external identifiers
  • scopus:85087616928
  • pmid:32628043
ISSN
0036-5513
DOI
10.1080/00365513.2020.1774641
project
AIR Lund - Artificially Intelligent use of Registers
language
English
LU publication?
yes
id
06515ab0-f3fb-4663-98fa-8ec01521b262
date added to LUP
2020-07-23 09:03:27
date last changed
2024-06-13 20:20:18
@article{06515ab0-f3fb-4663-98fa-8ec01521b262,
  abstract     = {{<p>The aim of this study was to establish creatinine growth curves separately for males and females that can be used to adjust childhood levels of serum creatinine to corresponding adult levels. Linear regression with fractional polynomials of age as independent variable was used to construct creatinine growth curves for a reference cohort (n = 83,157 samples from Belgium and Sweden, age 2–40 years). Adjusted creatinine obtained from the growth curves was used to improve accuracy of estimated glomerular filtration rate (eGFR) based on the Lund–Malmö revised (LMR) equation in children. The LMR equation based on creatinine values adjusted to age 18 years was validated against measured GFR (mGFR) in a separate cohort of 4005 children from four different European countries. Validation metrics included median bias, precision, and accuracy expressed as percentage of estimates within ±30% (P<sub>30</sub>) of mGFR. Remarkable improvements in bias and accuracy were observed; P<sub>30</sub> increased from 56% to 74% after creatinine adjustments in children with mGFR &lt;75 mL/min/1.73 m<sup>2</sup> (n = 932), while P<sub>30</sub> was relatively unchanged (89–90%) at mGFR ≥75 mL/min/1.73 m<sup>2</sup>(n = 3073). The suggested approach with adjusted creatinine makes LMR applicable in children irrespective of their renal function.</p>}},
  author       = {{Björk, Jonas and Nyman, Ulf and Delanaye, Pierre and Grubb, Anders and Larsson, Anders and Vranken, Laura and Åkesson, Anna and Pottel, Hans}},
  issn         = {{0036-5513}},
  keywords     = {{chronic kidney disease; Creatinine; glomerular filtration rate; kidney function tests; renal failure}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{6}},
  pages        = {{456--463}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical and Laboratory Investigation}},
  title        = {{A novel method for creatinine adjustment makes the revised Lund–Malmö GFR estimating equation applicable in children}},
  url          = {{http://dx.doi.org/10.1080/00365513.2020.1774641}},
  doi          = {{10.1080/00365513.2020.1774641}},
  volume       = {{80}},
  year         = {{2020}},
}