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Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing

Hao, Chengyu LU ; Gong, Lijing LU ; Cui, Xiaoxu LU ; Jönsson, Johanna LU orcid ; Zheng, Yunji LU ; Wu, Chengjun ; Kajitani, Naoko LU and Schwartz, Stefan LU (2022) In Archives of Virology 167(2). p.563-570
Abstract

We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hnRNP A2, hnRNP F, and hnRNP H efficiently induced HPV16 late gene expression, and all of the hnRNPs affected HPV16 L1 mRNA levels or mRNA splicing. Thus, the majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing. Strict control of the expression of the immunogenic L1 and L2 capsid proteins may contribute to the... (More)

We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hnRNP A2, hnRNP F, and hnRNP H efficiently induced HPV16 late gene expression, and all of the hnRNPs affected HPV16 L1 mRNA levels or mRNA splicing. Thus, the majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing. Strict control of the expression of the immunogenic L1 and L2 capsid proteins may contribute to the ability of HPV16 to cause persistence.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Virology
volume
167
issue
2
pages
563 - 570
publisher
Springer
external identifiers
  • scopus:85120558543
  • pmid:34860285
ISSN
0304-8608
DOI
10.1007/s00705-021-05317-2
language
English
LU publication?
yes
id
06f58c4f-e4c3-4b1c-8de2-3a7ac25b6b24
date added to LUP
2022-01-18 10:58:15
date last changed
2025-06-30 11:22:37
@article{06f58c4f-e4c3-4b1c-8de2-3a7ac25b6b24,
  abstract     = {{<p>We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hnRNP A2, hnRNP F, and hnRNP H efficiently induced HPV16 late gene expression, and all of the hnRNPs affected HPV16 L1 mRNA levels or mRNA splicing. Thus, the majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing. Strict control of the expression of the immunogenic L1 and L2 capsid proteins may contribute to the ability of HPV16 to cause persistence.</p>}},
  author       = {{Hao, Chengyu and Gong, Lijing and Cui, Xiaoxu and Jönsson, Johanna and Zheng, Yunji and Wu, Chengjun and Kajitani, Naoko and Schwartz, Stefan}},
  issn         = {{0304-8608}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{563--570}},
  publisher    = {{Springer}},
  series       = {{Archives of Virology}},
  title        = {{Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing}},
  url          = {{http://dx.doi.org/10.1007/s00705-021-05317-2}},
  doi          = {{10.1007/s00705-021-05317-2}},
  volume       = {{167}},
  year         = {{2022}},
}