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Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes—A Swedish Population-Based Study

Hedlund, Emma LU ; Tojjar, Jasaman LU ; Lilja, Lisa LU ; Elding Larsson, Helena LU orcid ; Forsander, Gun ; Ludvigsson, Johnny ; Marcus, Claude ; Norström, Fredrik LU ; Persson, Martina LU and Carlsson, Annelie LU orcid (2024) In Diabetes Care 47(11). p.2012-2016
Abstract

OBJECTIVE To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes. RESEARCH DESIGN AND METHODS Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA. RESULTS Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P < 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P =... (More)

OBJECTIVE To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes. RESEARCH DESIGN AND METHODS Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA. RESULTS Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P < 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P = 0.002). CONCLUSIONS A family history of T2D and being overweight may contribute to increased risk of T1D.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
47
issue
11
pages
5 pages
publisher
American Diabetes Association
external identifiers
  • pmid:39302847
  • scopus:85207597199
ISSN
0149-5992
DOI
10.2337/dc24-0534
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2024 by the American Diabetes Association.
id
0705ae96-2307-4368-80ae-2ebd0d59a2b5
date added to LUP
2024-12-05 13:39:14
date last changed
2025-01-30 18:36:52
@article{0705ae96-2307-4368-80ae-2ebd0d59a2b5,
  abstract     = {{<p>OBJECTIVE To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes. RESEARCH DESIGN AND METHODS Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA. RESULTS Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P &lt; 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P = 0.002). CONCLUSIONS A family history of T2D and being overweight may contribute to increased risk of T1D.</p>}},
  author       = {{Hedlund, Emma and Tojjar, Jasaman and Lilja, Lisa and Elding Larsson, Helena and Forsander, Gun and Ludvigsson, Johnny and Marcus, Claude and Norström, Fredrik and Persson, Martina and Carlsson, Annelie}},
  issn         = {{0149-5992}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2012--2016}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes—A Swedish Population-Based Study}},
  url          = {{http://dx.doi.org/10.2337/dc24-0534}},
  doi          = {{10.2337/dc24-0534}},
  volume       = {{47}},
  year         = {{2024}},
}