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Proliferating cell nuclear antigen (PCNA) in high‐grade malignant fibrous histiocytoma : Prognostic value in 48 patients

Dreinhöfer, Karsten E. ; Åkerman, Måns LU ; Willén, Helena ; Anderson, Christina ; Gustafson, Pelle LU and Rydholm, Anders LU (1994) In International Journal of Cancer 59(3). p.379-382
Abstract


Grading based on histopathologic features is used to predict survival in soft‐tissue sarcoma. However, variations in clinical behavior between tumors of the same grade motivate a search for additional factors that correlate with prognosis. Proliferating cell nuclear antigen (PCNA) is expressed in proliferating cells during the G
1
S and G
2
‐phases. To evaluate a prognostic implication of PCNA, the tumors of 48 patients with malignant fibrous histiocytomas (13 grade III, 35 grade IV) with a minimum follow‐up of 2 years were immunohistochemically studied.... (More)


Grading based on histopathologic features is used to predict survival in soft‐tissue sarcoma. However, variations in clinical behavior between tumors of the same grade motivate a search for additional factors that correlate with prognosis. Proliferating cell nuclear antigen (PCNA) is expressed in proliferating cells during the G
1
S and G
2
‐phases. To evaluate a prognostic implication of PCNA, the tumors of 48 patients with malignant fibrous histiocytomas (13 grade III, 35 grade IV) with a minimum follow‐up of 2 years were immunohistochemically studied. We used PC 10, a monoclonal antibody (MAb) directed against PCNA, which allows cell proliferation in formalin‐fixed, paraffinembedded tumor tissue to be evaluated. We appllied a semiquantitative PCNA grading scheme to all stained nuclei of an entire slide. The 3‐year metastasis‐free survival rate was 0.87 for patients in grade A (low PLNA rate), and 0.14 for patients in grade C (high PLNA). Our findings show that immunohistochemical evaluation of cell kinetics in soft‐tissue sarcomas by PCNA might be a useful adjunct to conventional tumor grading. © 1994 Wiley‐Liss, Inc.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
59
issue
3
pages
379 - 382
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:7927945
  • scopus:0028096804
ISSN
0020-7136
DOI
10.1002/ijc.2910590315
language
English
LU publication?
no
id
07236bb6-1c84-45df-ba34-210607fccb38
date added to LUP
2019-05-25 07:55:54
date last changed
2024-01-01 07:38:05
@article{07236bb6-1c84-45df-ba34-210607fccb38,
  abstract     = {{<p><br>
                            Grading based on histopathologic features is used to predict survival in soft‐tissue sarcoma. However, variations in clinical behavior between tumors of the same grade motivate a search for additional factors that correlate with prognosis. Proliferating cell nuclear antigen (PCNA) is expressed in proliferating cells during the G<br>
                            <sub>1</sub><br>
                             S and G<br>
                            <sub>2</sub><br>
                            ‐phases. To evaluate a prognostic implication of PCNA, the tumors of 48 patients with malignant fibrous histiocytomas (13 grade III, 35 grade IV) with a minimum follow‐up of 2 years were immunohistochemically studied. We used PC 10, a monoclonal antibody (MAb) directed against PCNA, which allows cell proliferation in formalin‐fixed, paraffinembedded tumor tissue to be evaluated. We appllied a semiquantitative PCNA grading scheme to all stained nuclei of an entire slide. The 3‐year metastasis‐free survival rate was 0.87 for patients in grade A (low PLNA rate), and 0.14 for patients in grade C (high PLNA). Our findings show that immunohistochemical evaluation of cell kinetics in soft‐tissue sarcomas by PCNA might be a useful adjunct to conventional tumor grading. © 1994 Wiley‐Liss, Inc.</p>}},
  author       = {{Dreinhöfer, Karsten E. and Åkerman, Måns and Willén, Helena and Anderson, Christina and Gustafson, Pelle and Rydholm, Anders}},
  issn         = {{0020-7136}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{3}},
  pages        = {{379--382}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Proliferating cell nuclear antigen (PCNA) in high‐grade malignant fibrous histiocytoma : Prognostic value in 48 patients}},
  url          = {{http://dx.doi.org/10.1002/ijc.2910590315}},
  doi          = {{10.1002/ijc.2910590315}},
  volume       = {{59}},
  year         = {{1994}},
}