Proliferating cell nuclear antigen (PCNA) in high‐grade malignant fibrous histiocytoma : Prognostic value in 48 patients
(1994) In International Journal of Cancer 59(3). p.379-382- Abstract
Grading based on histopathologic features is used to predict survival in soft‐tissue sarcoma. However, variations in clinical behavior between tumors of the same grade motivate a search for additional factors that correlate with prognosis. Proliferating cell nuclear antigen (PCNA) is expressed in proliferating cells during the G
1
S and G
2
‐phases. To evaluate a prognostic implication of PCNA, the tumors of 48 patients with malignant fibrous histiocytomas (13 grade III, 35 grade IV) with a minimum follow‐up of 2 years were immunohistochemically studied.... (More)
(Less)
Grading based on histopathologic features is used to predict survival in soft‐tissue sarcoma. However, variations in clinical behavior between tumors of the same grade motivate a search for additional factors that correlate with prognosis. Proliferating cell nuclear antigen (PCNA) is expressed in proliferating cells during the G
1
S and G
2
‐phases. To evaluate a prognostic implication of PCNA, the tumors of 48 patients with malignant fibrous histiocytomas (13 grade III, 35 grade IV) with a minimum follow‐up of 2 years were immunohistochemically studied. We used PC 10, a monoclonal antibody (MAb) directed against PCNA, which allows cell proliferation in formalin‐fixed, paraffinembedded tumor tissue to be evaluated. We appllied a semiquantitative PCNA grading scheme to all stained nuclei of an entire slide. The 3‐year metastasis‐free survival rate was 0.87 for patients in grade A (low PLNA rate), and 0.14 for patients in grade C (high PLNA). Our findings show that immunohistochemical evaluation of cell kinetics in soft‐tissue sarcomas by PCNA might be a useful adjunct to conventional tumor grading. © 1994 Wiley‐Liss, Inc.
- author
- Dreinhöfer, Karsten E. ; Åkerman, Måns LU ; Willén, Helena ; Anderson, Christina ; Gustafson, Pelle LU and Rydholm, Anders LU
- publishing date
- 1994-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Cancer
- volume
- 59
- issue
- 3
- pages
- 379 - 382
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0028096804
- pmid:7927945
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.2910590315
- language
- English
- LU publication?
- no
- id
- 07236bb6-1c84-45df-ba34-210607fccb38
- date added to LUP
- 2019-05-25 07:55:54
- date last changed
- 2024-01-01 07:38:05
@article{07236bb6-1c84-45df-ba34-210607fccb38, abstract = {{<p><br> Grading based on histopathologic features is used to predict survival in soft‐tissue sarcoma. However, variations in clinical behavior between tumors of the same grade motivate a search for additional factors that correlate with prognosis. Proliferating cell nuclear antigen (PCNA) is expressed in proliferating cells during the G<br> <sub>1</sub><br> S and G<br> <sub>2</sub><br> ‐phases. To evaluate a prognostic implication of PCNA, the tumors of 48 patients with malignant fibrous histiocytomas (13 grade III, 35 grade IV) with a minimum follow‐up of 2 years were immunohistochemically studied. We used PC 10, a monoclonal antibody (MAb) directed against PCNA, which allows cell proliferation in formalin‐fixed, paraffinembedded tumor tissue to be evaluated. We appllied a semiquantitative PCNA grading scheme to all stained nuclei of an entire slide. The 3‐year metastasis‐free survival rate was 0.87 for patients in grade A (low PLNA rate), and 0.14 for patients in grade C (high PLNA). Our findings show that immunohistochemical evaluation of cell kinetics in soft‐tissue sarcomas by PCNA might be a useful adjunct to conventional tumor grading. © 1994 Wiley‐Liss, Inc.</p>}}, author = {{Dreinhöfer, Karsten E. and Åkerman, Måns and Willén, Helena and Anderson, Christina and Gustafson, Pelle and Rydholm, Anders}}, issn = {{0020-7136}}, language = {{eng}}, month = {{11}}, number = {{3}}, pages = {{379--382}}, publisher = {{John Wiley & Sons Inc.}}, series = {{International Journal of Cancer}}, title = {{Proliferating cell nuclear antigen (PCNA) in high‐grade malignant fibrous histiocytoma : Prognostic value in 48 patients}}, url = {{http://dx.doi.org/10.1002/ijc.2910590315}}, doi = {{10.1002/ijc.2910590315}}, volume = {{59}}, year = {{1994}}, }