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Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes

Lenshof, A. LU ; Magnusson, Cecilia LU ; Augustsson, P. LU ; Haflidadottir, B. LU ; Lilja, H. LU orcid and Laurell, T. LU (2014) 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 p.594-596
Abstract

We present an improved acoustophoretic system for circulating tumor cell separation from blood. The system is operated by pressure driven flow, including flow sensors and a feed-back loop for precise flow control. The pressure driven system provides a user interface that can be handled by a non-skilled operator, and most importantly full clinical samples of 7 mL can be processed in 70 minutes. The improved flow control enables recovery of rare tumor cell populations ≈10 cells/mL spiked in whole blood at a recovery close to 100%.

Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustophoresis, Cancer, Circulation tumor cells, Rare cell, Separation
host publication
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
series title
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
pages
594 - 596
publisher
Chemical and Biological Microsystems Society
conference name
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
conference location
San Antonio, United States
conference dates
2014-10-26 - 2014-10-30
external identifiers
  • scopus:84941687206
ISBN
9780979806476
language
English
LU publication?
yes
additional info
Publisher Copyright: © 14CBMS.
id
07508598-3cb8-4425-a1d3-a03ecb775584
date added to LUP
2023-02-10 11:14:40
date last changed
2023-03-06 15:33:09
@inproceedings{07508598-3cb8-4425-a1d3-a03ecb775584,
  abstract     = {{<p>We present an improved acoustophoretic system for circulating tumor cell separation from blood. The system is operated by pressure driven flow, including flow sensors and a feed-back loop for precise flow control. The pressure driven system provides a user interface that can be handled by a non-skilled operator, and most importantly full clinical samples of 7 mL can be processed in 70 minutes. The improved flow control enables recovery of rare tumor cell populations ≈10 cells/mL spiked in whole blood at a recovery close to 100%.</p>}},
  author       = {{Lenshof, A. and Magnusson, Cecilia and Augustsson, P. and Haflidadottir, B. and Lilja, H. and Laurell, T.}},
  booktitle    = {{18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014}},
  isbn         = {{9780979806476}},
  keywords     = {{Acoustophoresis; Cancer; Circulation tumor cells; Rare cell; Separation}},
  language     = {{eng}},
  pages        = {{594--596}},
  publisher    = {{Chemical and Biological Microsystems Society}},
  series       = {{18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014}},
  title        = {{Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes}},
  year         = {{2014}},
}