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Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia

Ivanov Öfverholm, Ingegerd; Tran, Anh Nhi; Olsson, Linda LU ; Zachariadis, Vasilios; Heyman, Mats; Rudd, Eva; Syk Lundberg, Elisabeth; Nordenskjöld, Magnus; Johansson, Bertil LU and Nordgren, Ann, et al. (2016) In Leukemia & Lymphoma 57(9). p.2161-2170
Abstract

To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated in BCP ALL, e.g. INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and deletions of SH2B3 were associated with intrachromosomal amplification of chromosome 21 (p 

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organization
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type
Contribution to journal
publication status
published
subject
keywords
B-Other, CNA, copy number, deletion, pediatric ALL
in
Leukemia & Lymphoma
volume
57
issue
9
pages
10 pages
publisher
Taylor & Francis
external identifiers
  • scopus:84963812828
  • wos:000381372800022
ISSN
1042-8194
DOI
10.3109/10428194.2015.1136740
language
English
LU publication?
yes
id
075e7f00-cc55-47d3-a6c2-e62010fbd145
date added to LUP
2016-06-21 15:39:06
date last changed
2017-10-22 05:16:44
@article{075e7f00-cc55-47d3-a6c2-e62010fbd145,
  abstract     = {<p>To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated in BCP ALL, e.g. INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and deletions of SH2B3 were associated with intrachromosomal amplification of chromosome 21 (p </p>},
  author       = {Ivanov Öfverholm, Ingegerd and Tran, Anh Nhi and Olsson, Linda and Zachariadis, Vasilios and Heyman, Mats and Rudd, Eva and Syk Lundberg, Elisabeth and Nordenskjöld, Magnus and Johansson, Bertil and Nordgren, Ann and Barbany, Gisela},
  issn         = {1042-8194},
  keyword      = {B-Other,CNA,copy number,deletion,pediatric ALL},
  language     = {eng},
  month        = {04},
  number       = {9},
  pages        = {2161--2170},
  publisher    = {Taylor & Francis},
  series       = {Leukemia & Lymphoma},
  title        = {Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.3109/10428194.2015.1136740},
  volume       = {57},
  year         = {2016},
}