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Disparities in colorectal cancer between Northern and SouthernSweden–a report from the new RISK North database

Sjöström, Olof; Silander, Gustav; Syk, Ingvar LU ; Henriksson, Roger; Melin, Beatrice and Hellquist, Barbro N. (2018) In Acta Oncologica 57(12). p.1622-1630
Abstract

Background: Geographic cancer health disparities have been reported in Sweden. The disparities are not fully understood, but may be attributed to differences in exposure to risk factors as well as differences in health care, socioeconomics and demography. The aim of this study was to describe the new nationwide population based RISK North database and its potential by analysing health disparities in colorectal cancer between Northern and Southern Sweden. Methods: Cancer-specific data from the National Cancer Quality Registers for colorectal, gastric and oesophageal cancer and brain tumours were linked to several nationwide registers hereby creating a new database–RISK North. To exemplify the potential of RISK North, we analyzed... (More)

Background: Geographic cancer health disparities have been reported in Sweden. The disparities are not fully understood, but may be attributed to differences in exposure to risk factors as well as differences in health care, socioeconomics and demography. The aim of this study was to describe the new nationwide population based RISK North database and its potential by analysing health disparities in colorectal cancer between Northern and Southern Sweden. Methods: Cancer-specific data from the National Cancer Quality Registers for colorectal, gastric and oesophageal cancer and brain tumours were linked to several nationwide registers hereby creating a new database–RISK North. To exemplify the potential of RISK North, we analyzed differences in colorectal cancer incidence, mortality and survival in relation to gender, age, cohabitation and education between Northern and Southern Sweden 2007–2013. Results: In colon cancer, the age-adjusted incidence per 100.000 was lower in Northern than Southern Sweden, 35.9 in the North vs. 41.1 in the South (p <.01); mortality rates were 11.0 vs. 12.2 (p <.01). For rectal cancer, incidence rates were 17.6 vs. 19.7 (p <.01) and mortality rates 5.33 vs. 5.89 (p =.07), respectively. The largest difference in incidence was demonstrated for colon cancer among individuals >79 years old (190. vs. 237, i.e., ∼20%). Survival in colon cancer was higher in Southern Sweden, HR 0.92 (0.87–0.98) adjusted for age, gender, co-habiting, education and m-stage at diagnosis. No difference in survival was seen for rectal cancer. Conclusions: The new RISK North database enabled analysis of cancer disparities between Northern and Southern Sweden. The incidence of colorectal cancer were lower in the North of Sweden whereas colon cancer survival was higher in the South. These differences can be further analysed utilising the RISK North database.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
57
issue
12
pages
1622 - 1630
publisher
Taylor & Francis
external identifiers
  • scopus:85054505987
ISSN
0284-186X
DOI
10.1080/0284186X.2018.1497300
language
English
LU publication?
yes
id
0776abd9-2e32-4dba-9e6d-834ed8657457
date added to LUP
2018-11-07 08:20:04
date last changed
2019-02-20 11:34:41
@article{0776abd9-2e32-4dba-9e6d-834ed8657457,
  abstract     = {<p>Background: Geographic cancer health disparities have been reported in Sweden. The disparities are not fully understood, but may be attributed to differences in exposure to risk factors as well as differences in health care, socioeconomics and demography. The aim of this study was to describe the new nationwide population based RISK North database and its potential by analysing health disparities in colorectal cancer between Northern and Southern Sweden. Methods: Cancer-specific data from the National Cancer Quality Registers for colorectal, gastric and oesophageal cancer and brain tumours were linked to several nationwide registers hereby creating a new database–RISK North. To exemplify the potential of RISK North, we analyzed differences in colorectal cancer incidence, mortality and survival in relation to gender, age, cohabitation and education between Northern and Southern Sweden 2007–2013. Results: In colon cancer, the age-adjusted incidence per 100.000 was lower in Northern than Southern Sweden, 35.9 in the North vs. 41.1 in the South (p &lt;.01); mortality rates were 11.0 vs. 12.2 (p &lt;.01). For rectal cancer, incidence rates were 17.6 vs. 19.7 (p &lt;.01) and mortality rates 5.33 vs. 5.89 (p =.07), respectively. The largest difference in incidence was demonstrated for colon cancer among individuals &gt;79 years old (190. vs. 237, i.e., ∼20%). Survival in colon cancer was higher in Southern Sweden, HR 0.92 (0.87–0.98) adjusted for age, gender, co-habiting, education and m-stage at diagnosis. No difference in survival was seen for rectal cancer. Conclusions: The new RISK North database enabled analysis of cancer disparities between Northern and Southern Sweden. The incidence of colorectal cancer were lower in the North of Sweden whereas colon cancer survival was higher in the South. These differences can be further analysed utilising the RISK North database.</p>},
  author       = {Sjöström, Olof and Silander, Gustav and Syk, Ingvar and Henriksson, Roger and Melin, Beatrice and Hellquist, Barbro N.},
  issn         = {0284-186X},
  language     = {eng},
  month        = {12},
  number       = {12},
  pages        = {1622--1630},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Disparities in colorectal cancer between Northern and SouthernSweden–a report from the new RISK North database},
  url          = {http://dx.doi.org/10.1080/0284186X.2018.1497300},
  volume       = {57},
  year         = {2018},
}