Streptococcal M proteins and their role as virulence determinants.
Oehmcke, Sonja LU ; Shannon, Oonagh LU ; Mörgelin, Matthias LU and Herwald, Heiko LU
(2010)
In Clinica Chimica Acta
411.
p.1172-1180
- Abstract
- Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that have been extensively studied for many decades. The spectrum of diseases caused by these bacteria ranges from uncomplicated and superficial to severe and invasive infections. In order to give rise to these complications, GAS have evolved a number of surface-bound and secreted virulence factors, of which the M proteins are probably the best characterized. Evidence has emerged that M proteins are multifunctional pathogenic determinants, and over the years many interactions between M proteins and the human host have been reported. The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M... (More)
- Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that have been extensively studied for many decades. The spectrum of diseases caused by these bacteria ranges from uncomplicated and superficial to severe and invasive infections. In order to give rise to these complications, GAS have evolved a number of surface-bound and secreted virulence factors, of which the M proteins are probably the best characterized. Evidence has emerged that M proteins are multifunctional pathogenic determinants, and over the years many interactions between M proteins and the human host have been reported. The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M proteins to trigger disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1610473
- author
- Oehmcke, Sonja
LU
; Shannon, Oonagh
LU
; Mörgelin, Matthias
LU
and Herwald, Heiko
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinica Chimica Acta
- volume
- 411
- pages
- 1172 - 1180
- publisher
- Elsevier
- external identifiers
-
- wos:000280033400002
- pmid:20452338
- scopus:77954144724
- pmid:20452338
- ISSN
- 0009-8981
- DOI
- 10.1016/j.cca.2010.04.032
- language
- English
- LU publication?
- yes
- id
- 07a75db1-f8de-432b-bb62-7a871a520e56 (old id 1610473)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20452338?dopt=Abstract
- date added to LUP
- 2016-04-04 08:49:41
- date last changed
- 2022-03-15 08:51:09
@article{07a75db1-f8de-432b-bb62-7a871a520e56,
abstract = {{Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that have been extensively studied for many decades. The spectrum of diseases caused by these bacteria ranges from uncomplicated and superficial to severe and invasive infections. In order to give rise to these complications, GAS have evolved a number of surface-bound and secreted virulence factors, of which the M proteins are probably the best characterized. Evidence has emerged that M proteins are multifunctional pathogenic determinants, and over the years many interactions between M proteins and the human host have been reported. The present review article aims to present a state-of-the-art overview of the most important virulence mechanisms employed by M proteins to trigger disease.}},
author = {{Oehmcke, Sonja and Shannon, Oonagh and Mörgelin, Matthias and Herwald, Heiko}},
issn = {{0009-8981}},
language = {{eng}},
pages = {{1172--1180}},
publisher = {{Elsevier}},
series = {{Clinica Chimica Acta}},
title = {{Streptococcal M proteins and their role as virulence determinants.}},
url = {{http://dx.doi.org/10.1016/j.cca.2010.04.032}},
doi = {{10.1016/j.cca.2010.04.032}},
volume = {{411}},
year = {{2010}},
}