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Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation

Ghaidan, Haider LU orcid ; Stenlo, Martin LU ; Niroomand, Anna LU ; Mittendorfer, Margareta LU ; Hirdman, Gabriel LU ; Gvazava, Nika LU ; Edström, Dag LU ; Augusto Silva, Iran LU orcid ; Broberg, Ellen LU and Hallgren, Oskar LU , et al. (2022) In Nature Communications 13(1).
Abstract

Despite improvements, lung transplantation remains hampered by both a scarcity of donor organs and by mortality following primary graft dysfunction (PGD). Since acute respiratory distress syndrome (ARDS) limits donor lungs utilization, we investigated cytokine adsorption as a means of treating ARDS donor lungs. We induced mild to moderate ARDS using lipopolysaccharide in 16 donor pigs. Lungs were then treated with or without cytokine adsorption during ex vivo lung perfusion (EVLP) and/or post-transplantation using extracorporeal hemoperfusion. The treatment significantly decreased cytokine levels during EVLP and decreased levels of immune cells post-transplantation. Histology demonstrated fewer signs of lung injury across both treatment... (More)

Despite improvements, lung transplantation remains hampered by both a scarcity of donor organs and by mortality following primary graft dysfunction (PGD). Since acute respiratory distress syndrome (ARDS) limits donor lungs utilization, we investigated cytokine adsorption as a means of treating ARDS donor lungs. We induced mild to moderate ARDS using lipopolysaccharide in 16 donor pigs. Lungs were then treated with or without cytokine adsorption during ex vivo lung perfusion (EVLP) and/or post-transplantation using extracorporeal hemoperfusion. The treatment significantly decreased cytokine levels during EVLP and decreased levels of immune cells post-transplantation. Histology demonstrated fewer signs of lung injury across both treatment periods and the incidence of PGD was significantly reduced among treated animals. Overall, cytokine adsorption was able to restore lung function and reduce PGD in lung transplantation. We suggest this treatment will increase the availability of donor lungs and increase the tolerability of donor lungs in the recipient.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
13
issue
1
article number
4173
publisher
Nature Publishing Group
external identifiers
  • scopus:85135021848
  • pmid:35882835
ISSN
2041-1723
DOI
10.1038/s41467-022-31811-5
language
English
LU publication?
yes
id
07b7fd00-a25c-4ea4-bf65-eea825d60bd0
date added to LUP
2022-07-28 13:34:32
date last changed
2024-11-12 23:47:21
@article{07b7fd00-a25c-4ea4-bf65-eea825d60bd0,
  abstract     = {{<p>Despite improvements, lung transplantation remains hampered by both a scarcity of donor organs and by mortality following primary graft dysfunction (PGD). Since acute respiratory distress syndrome (ARDS) limits donor lungs utilization, we investigated cytokine adsorption as a means of treating ARDS donor lungs. We induced mild to moderate ARDS using lipopolysaccharide in 16 donor pigs. Lungs were then treated with or without cytokine adsorption during ex vivo lung perfusion (EVLP) and/or post-transplantation using extracorporeal hemoperfusion. The treatment significantly decreased cytokine levels during EVLP and decreased levels of immune cells post-transplantation. Histology demonstrated fewer signs of lung injury across both treatment periods and the incidence of PGD was significantly reduced among treated animals. Overall, cytokine adsorption was able to restore lung function and reduce PGD in lung transplantation. We suggest this treatment will increase the availability of donor lungs and increase the tolerability of donor lungs in the recipient.</p>}},
  author       = {{Ghaidan, Haider and Stenlo, Martin and Niroomand, Anna and Mittendorfer, Margareta and Hirdman, Gabriel and Gvazava, Nika and Edström, Dag and Augusto Silva, Iran and Broberg, Ellen and Hallgren, Oskar and Olm, Franziska and Wagner, Darcy E and Pierre, Leif and Hyllén, Snejana and Lindstedt, Sandra}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation}},
  url          = {{http://dx.doi.org/10.1038/s41467-022-31811-5}},
  doi          = {{10.1038/s41467-022-31811-5}},
  volume       = {{13}},
  year         = {{2022}},
}