Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants
(2009) In European Journal of Clinical Pharmacology 65(6). p.615-625- Abstract
- Purpose To investigate the association between maternal use of antihypertensives in early pregnancy and delivery outcome, notably infant congenital malformations. Methods A cohort study of 1,418 women who had used antihypertensive drugs in early pregnancy but had no diabetes diagnosis were identified from the Swedish Medical Birth Register. Results There was an excess risk for placental abruption, caesarean section, delivery induction, and post-delivery hemorrhage in women taking hypertensives. Infants were more often than expected born preterm, were small for gestational age, and had an excess of various neonatal symptoms. Cardiovascular defects occurred with an adjusted odds ratio of 2.59 (95% CI 1.92-3.51). The results were similar when... (More)
- Purpose To investigate the association between maternal use of antihypertensives in early pregnancy and delivery outcome, notably infant congenital malformations. Methods A cohort study of 1,418 women who had used antihypertensive drugs in early pregnancy but had no diabetes diagnosis were identified from the Swedish Medical Birth Register. Results There was an excess risk for placental abruption, caesarean section, delivery induction, and post-delivery hemorrhage in women taking hypertensives. Infants were more often than expected born preterm, were small for gestational age, and had an excess of various neonatal symptoms. Cardiovascular defects occurred with an adjusted odds ratio of 2.59 (95% CI 1.92-3.51). The results were similar when the woman had used ACE inhibitors or other antihypertensives, notably beta blockers. Stillbirth rate was increased (risk ratio 1.87, 95% CI 1.02-3.02), again without any clear drug specificity. Conclusions There seems to be little drug specificity in the association between maternal use of antihypertensives and an increased risk for infant cardiovascular defects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1442279
- author
- Lennestal, Roland ; Olausson, Petra Otterblad and Källén, Bengt LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antihypertensives, Beta-blocking agents, Cardiovascular, defects, Stillbirths, Congenital malformations, ACE inhibitors
- in
- European Journal of Clinical Pharmacology
- volume
- 65
- issue
- 6
- pages
- 615 - 625
- publisher
- Springer
- external identifiers
-
- wos:000266886000010
- scopus:68849090817
- pmid:19198819
- ISSN
- 1432-1041
- DOI
- 10.1007/s00228-009-0620-0
- language
- English
- LU publication?
- yes
- id
- 07ba659e-8d49-48ea-b02d-bca27842e124 (old id 1442279)
- date added to LUP
- 2016-04-01 13:49:38
- date last changed
- 2022-02-19 07:41:00
@article{07ba659e-8d49-48ea-b02d-bca27842e124,
abstract = {{Purpose To investigate the association between maternal use of antihypertensives in early pregnancy and delivery outcome, notably infant congenital malformations. Methods A cohort study of 1,418 women who had used antihypertensive drugs in early pregnancy but had no diabetes diagnosis were identified from the Swedish Medical Birth Register. Results There was an excess risk for placental abruption, caesarean section, delivery induction, and post-delivery hemorrhage in women taking hypertensives. Infants were more often than expected born preterm, were small for gestational age, and had an excess of various neonatal symptoms. Cardiovascular defects occurred with an adjusted odds ratio of 2.59 (95% CI 1.92-3.51). The results were similar when the woman had used ACE inhibitors or other antihypertensives, notably beta blockers. Stillbirth rate was increased (risk ratio 1.87, 95% CI 1.02-3.02), again without any clear drug specificity. Conclusions There seems to be little drug specificity in the association between maternal use of antihypertensives and an increased risk for infant cardiovascular defects.}},
author = {{Lennestal, Roland and Olausson, Petra Otterblad and Källén, Bengt}},
issn = {{1432-1041}},
keywords = {{Antihypertensives; Beta-blocking agents; Cardiovascular; defects; Stillbirths; Congenital malformations; ACE inhibitors}},
language = {{eng}},
number = {{6}},
pages = {{615--625}},
publisher = {{Springer}},
series = {{European Journal of Clinical Pharmacology}},
title = {{Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants}},
url = {{http://dx.doi.org/10.1007/s00228-009-0620-0}},
doi = {{10.1007/s00228-009-0620-0}},
volume = {{65}},
year = {{2009}},
}